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Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.
J Neuroimmunol 2009; 211(1-2):105-9JN

Abstract

Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and one SNP (rs791589) in the first intron of the IL2RA gene remained associated after adjustment for rs2104286 genotype, a previously reported SNP association. These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles.

Authors+Show Affiliations

Menzies Research Institute, University of Tasmania, Hobart, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19375175

Citation

Perera, Devindri, et al. "Fine Mapping of Multiple Sclerosis Susceptibility Genes Provides Evidence of Allelic Heterogeneity at the IL2RA Locus." Journal of Neuroimmunology, vol. 211, no. 1-2, 2009, pp. 105-9.
Perera D, Stankovich J, Butzkueven H, et al. Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. J Neuroimmunol. 2009;211(1-2):105-9.
Perera, D., Stankovich, J., Butzkueven, H., Taylor, B. V., Foote, S. J., Kilpatrick, T. J., & Rubio, J. P. (2009). Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. Journal of Neuroimmunology, 211(1-2), pp. 105-9. doi:10.1016/j.jneuroim.2009.03.010.
Perera D, et al. Fine Mapping of Multiple Sclerosis Susceptibility Genes Provides Evidence of Allelic Heterogeneity at the IL2RA Locus. J Neuroimmunol. 2009 Jun 25;211(1-2):105-9. PubMed PMID: 19375175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. AU - Perera,Devindri, AU - Stankovich,Jim, AU - Butzkueven,Helmut, AU - Taylor,Bruce V, AU - Foote,Simon J, AU - Kilpatrick,Trevor J, AU - Rubio,Justin P, Y1 - 2009/04/17/ PY - 2008/12/05/received PY - 2009/03/06/revised PY - 2009/03/06/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/7/8/medline SP - 105 EP - 9 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 211 IS - 1-2 N2 - Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and one SNP (rs791589) in the first intron of the IL2RA gene remained associated after adjustment for rs2104286 genotype, a previously reported SNP association. These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/19375175/Fine_mapping_of_multiple_sclerosis_susceptibility_genes_provides_evidence_of_allelic_heterogeneity_at_the_IL2RA_locus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(09)00104-0 DB - PRIME DP - Unbound Medicine ER -