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Concordance of retinal nerve fiber layer defects between fellow eyes of glaucoma patients measured by optical coherence tomography.
Am J Ophthalmol 2009; 148(1):148-54AJ

Abstract

PURPOSE

To determine the pattern of agreement of retinal nerve fiber layer (RNFL) defects between fellow eyes of glaucoma patients measured with optical coherence tomography (OCT).

DESIGN

Observational, cross-sectional study.

METHODS

Seventy-seven glaucoma patients (154 eyes) underwent OCT (Stratus) imaging with the fast RNFL thickness protocol in both eyes. RNFL thickness at each location (12 clock-hour sectors and 4 quadrants) was measured. Main outcome measures were correlations between fellow eyes for RNFL thickness and categorical classifications of RNFL thickness. Nonfellow pairs of eyes, matched randomly, were used as controls.

RESULTS

Fellow eyes showed significant correlations of RNFL thickness in all sectors and quadrants. Categorical ranking also showed significant agreement between fellow eyes in sectors 1 (P < .01) and 7 (P < .03), and in the superior quadrant (P < .01), inferior quadrant (P < .04), and total RNFL thickness (P < .04). None of the paired eyes in the control analysis showed significant correlations.

CONCLUSIONS

The measurement of RNFL thickness and its categorical classification with OCT identified symmetry between fellow eyes of glaucoma patients. Categorical agreement on defective locations was found mostly for the inferior and superior locations, which corresponds with the typical pattern of early glaucomatous damage. Glaucomatous RNFL damage in 1 eye is correlated with damage at corresponding locations of the fellow eye.

Authors+Show Affiliations

Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19375690

Citation

Bertuzzi, Francesca, et al. "Concordance of Retinal Nerve Fiber Layer Defects Between Fellow Eyes of Glaucoma Patients Measured By Optical Coherence Tomography." American Journal of Ophthalmology, vol. 148, no. 1, 2009, pp. 148-54.
Bertuzzi F, Hoffman DC, De Fonseka AM, et al. Concordance of retinal nerve fiber layer defects between fellow eyes of glaucoma patients measured by optical coherence tomography. Am J Ophthalmol. 2009;148(1):148-54.
Bertuzzi, F., Hoffman, D. C., De Fonseka, A. M., Souza, C., & Caprioli, J. (2009). Concordance of retinal nerve fiber layer defects between fellow eyes of glaucoma patients measured by optical coherence tomography. American Journal of Ophthalmology, 148(1), pp. 148-54. doi:10.1016/j.ajo.2009.02.009.
Bertuzzi F, et al. Concordance of Retinal Nerve Fiber Layer Defects Between Fellow Eyes of Glaucoma Patients Measured By Optical Coherence Tomography. Am J Ophthalmol. 2009;148(1):148-54. PubMed PMID: 19375690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concordance of retinal nerve fiber layer defects between fellow eyes of glaucoma patients measured by optical coherence tomography. AU - Bertuzzi,Francesca, AU - Hoffman,Douglas C, AU - De Fonseka,Arushi M, AU - Souza,Carlos, AU - Caprioli,Joseph, Y1 - 2009/04/18/ PY - 2008/02/26/received PY - 2009/02/03/revised PY - 2009/02/03/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/7/2/medline SP - 148 EP - 54 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 148 IS - 1 N2 - PURPOSE: To determine the pattern of agreement of retinal nerve fiber layer (RNFL) defects between fellow eyes of glaucoma patients measured with optical coherence tomography (OCT). DESIGN: Observational, cross-sectional study. METHODS: Seventy-seven glaucoma patients (154 eyes) underwent OCT (Stratus) imaging with the fast RNFL thickness protocol in both eyes. RNFL thickness at each location (12 clock-hour sectors and 4 quadrants) was measured. Main outcome measures were correlations between fellow eyes for RNFL thickness and categorical classifications of RNFL thickness. Nonfellow pairs of eyes, matched randomly, were used as controls. RESULTS: Fellow eyes showed significant correlations of RNFL thickness in all sectors and quadrants. Categorical ranking also showed significant agreement between fellow eyes in sectors 1 (P < .01) and 7 (P < .03), and in the superior quadrant (P < .01), inferior quadrant (P < .04), and total RNFL thickness (P < .04). None of the paired eyes in the control analysis showed significant correlations. CONCLUSIONS: The measurement of RNFL thickness and its categorical classification with OCT identified symmetry between fellow eyes of glaucoma patients. Categorical agreement on defective locations was found mostly for the inferior and superior locations, which corresponds with the typical pattern of early glaucomatous damage. Glaucomatous RNFL damage in 1 eye is correlated with damage at corresponding locations of the fellow eye. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/19375690/Concordance_of_retinal_nerve_fiber_layer_defects_between_fellow_eyes_of_glaucoma_patients_measured_by_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00106-8 DB - PRIME DP - Unbound Medicine ER -