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Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake.
Metabolism. 2009 Jun; 58(6):803-11.M

Abstract

The relation between alternate-day fasting (ADF) and cardioprotection remains uncertain. In the present study, we examined the ability of modified ADF, with a low-fat (LF) vs high-fat (HF) background diet, to modulate adipose tissue physiology in a way that may protect against coronary heart disease. In a 4-week study, male C57BL/6 mice were randomized to 1 of 3 groups: (1) ADF-85%-LF (85% energy restriction on fast day, ad libitum fed on feed day, on an LF diet), (2) ADF-85%-HF (same protocol but HF diet), and (3) control (ad libitum fed). Throughout the study, body weight did not differ between ADF and control animals. Proportion of subcutaneous fat increased (P < .01), whereas the proportion of visceral fat decreased (P < .01), in both ADF groups. Triglyceride (TG) synthesis was augmented (P < .05) in subcutaneous fat, but remained unchanged in visceral fat. Adiponectin concentrations were elevated (P < .05), whereas leptin and resistin levels decreased (P < .05). Aortic vascular smooth muscle cell proliferation was reduced (P < .05) by 60% and 76% on the LF and HF diets, respectively. Plasma total cholesterol, TG, and free fatty acid concentrations also decreased (P < .05). In summary, modified ADF regimens alter adipose tissue physiology (ie, body fat distribution, TG metabolism, and adipokines) in a way that may protect against coronary heart disease. These beneficial effects were noted over a wide range of fat intake, suggesting that ADF may be protective even in the presence of HF diets.

Authors+Show Affiliations

Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA. kvarady@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19375762

Citation

Varady, Krista A., et al. "Modified Alternate-day Fasting and Cardioprotection: Relation to Adipose Tissue Dynamics and Dietary Fat Intake." Metabolism: Clinical and Experimental, vol. 58, no. 6, 2009, pp. 803-11.
Varady KA, Hudak CS, Hellerstein MK. Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake. Metabolism. 2009;58(6):803-11.
Varady, K. A., Hudak, C. S., & Hellerstein, M. K. (2009). Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake. Metabolism: Clinical and Experimental, 58(6), 803-11. https://doi.org/10.1016/j.metabol.2009.01.018
Varady KA, Hudak CS, Hellerstein MK. Modified Alternate-day Fasting and Cardioprotection: Relation to Adipose Tissue Dynamics and Dietary Fat Intake. Metabolism. 2009;58(6):803-11. PubMed PMID: 19375762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake. AU - Varady,Krista A, AU - Hudak,Carolyn S, AU - Hellerstein,Marc K, PY - 2008/11/07/received PY - 2009/01/28/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/6/11/medline SP - 803 EP - 11 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 6 N2 - The relation between alternate-day fasting (ADF) and cardioprotection remains uncertain. In the present study, we examined the ability of modified ADF, with a low-fat (LF) vs high-fat (HF) background diet, to modulate adipose tissue physiology in a way that may protect against coronary heart disease. In a 4-week study, male C57BL/6 mice were randomized to 1 of 3 groups: (1) ADF-85%-LF (85% energy restriction on fast day, ad libitum fed on feed day, on an LF diet), (2) ADF-85%-HF (same protocol but HF diet), and (3) control (ad libitum fed). Throughout the study, body weight did not differ between ADF and control animals. Proportion of subcutaneous fat increased (P < .01), whereas the proportion of visceral fat decreased (P < .01), in both ADF groups. Triglyceride (TG) synthesis was augmented (P < .05) in subcutaneous fat, but remained unchanged in visceral fat. Adiponectin concentrations were elevated (P < .05), whereas leptin and resistin levels decreased (P < .05). Aortic vascular smooth muscle cell proliferation was reduced (P < .05) by 60% and 76% on the LF and HF diets, respectively. Plasma total cholesterol, TG, and free fatty acid concentrations also decreased (P < .05). In summary, modified ADF regimens alter adipose tissue physiology (ie, body fat distribution, TG metabolism, and adipokines) in a way that may protect against coronary heart disease. These beneficial effects were noted over a wide range of fat intake, suggesting that ADF may be protective even in the presence of HF diets. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19375762/Modified_alternate_day_fasting_and_cardioprotection:_relation_to_adipose_tissue_dynamics_and_dietary_fat_intake_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00057-2 DB - PRIME DP - Unbound Medicine ER -