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NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro.
Brain Res. 2009 Jun 05; 1274:40-6.BR

Abstract

N-methyl-D-aspartate receptors (NMDARs) have been implicated in various forms of synaptic plasticity. In recent years, studies have been shown that NMDA receptor subunits play different roles in several forms of NMDAR-dependent synaptic plasticity. However, the contribution of NR2A and NR2B subunits in the induction of long-term potentiation (LTP) in the corticostriatal pathway remains unclear. The present study used patch-clamp recordings to study the role of NR2A-containing and NR2B-containing NMDARs in LTP induction in corticostriatal slices from 13-14-day old rats. High-frequency stimulation (HFS) of the corticostriatal pathway readily induced LTP of excitatory postsynaptic currents (EPSCs), and D-APV, a selective NMDAR antagonist, blocked LTP. Moreover, NR2B-containing NMDAR antagonists (Ro 25-6981 and ifenprodil) displayed no influence on LTP induction. However, LTP was not inducible in the presence of Zn(2+), an NR2A-containing NMDAR antagonist. These results suggest that the induction of LTP by HFS in the dorsolateral striatum is NMDAR-dependent and requires NR2A-containing NMDARs, not NR2B-containing NMDARs.

Authors+Show Affiliations

Department of Physiology, School of Medicine, Xi'an Jiaotong University, Zhuque Dajie 205, Xi'an, 710061, PR China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19376094

Citation

Li, Ping, et al. "NR2A-containing NMDA Receptors Are Required for LTP Induction in Rat Dorsolateral Striatum in Vitro." Brain Research, vol. 1274, 2009, pp. 40-6.
Li P, Li YH, Han TZ. NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro. Brain Res. 2009;1274:40-6.
Li, P., Li, Y. H., & Han, T. Z. (2009). NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro. Brain Research, 1274, 40-6. https://doi.org/10.1016/j.brainres.2009.04.016
Li P, Li YH, Han TZ. NR2A-containing NMDA Receptors Are Required for LTP Induction in Rat Dorsolateral Striatum in Vitro. Brain Res. 2009 Jun 5;1274:40-6. PubMed PMID: 19376094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro. AU - Li,Ping, AU - Li,Yan-Hai, AU - Han,Tai-Zhen, Y1 - 2009/04/17/ PY - 2008/11/23/received PY - 2009/04/07/revised PY - 2009/04/10/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/7/30/medline SP - 40 EP - 6 JF - Brain research JO - Brain Res VL - 1274 N2 - N-methyl-D-aspartate receptors (NMDARs) have been implicated in various forms of synaptic plasticity. In recent years, studies have been shown that NMDA receptor subunits play different roles in several forms of NMDAR-dependent synaptic plasticity. However, the contribution of NR2A and NR2B subunits in the induction of long-term potentiation (LTP) in the corticostriatal pathway remains unclear. The present study used patch-clamp recordings to study the role of NR2A-containing and NR2B-containing NMDARs in LTP induction in corticostriatal slices from 13-14-day old rats. High-frequency stimulation (HFS) of the corticostriatal pathway readily induced LTP of excitatory postsynaptic currents (EPSCs), and D-APV, a selective NMDAR antagonist, blocked LTP. Moreover, NR2B-containing NMDAR antagonists (Ro 25-6981 and ifenprodil) displayed no influence on LTP induction. However, LTP was not inducible in the presence of Zn(2+), an NR2A-containing NMDAR antagonist. These results suggest that the induction of LTP by HFS in the dorsolateral striatum is NMDAR-dependent and requires NR2A-containing NMDARs, not NR2B-containing NMDARs. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19376094/NR2A_containing_NMDA_receptors_are_required_for_LTP_induction_in_rat_dorsolateral_striatum_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)00775-6 DB - PRIME DP - Unbound Medicine ER -