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Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment.

Abstract

Alzheimer's disease (AD) is the most common type of dementia in the elderly. Products of oxidative and nitrosative stress (OS and NS, respectively) accumulate with aging, which is the main risk factor for AD. This provides the basis for the involvement of OS and NS in AD pathogenesis. OS and NS occur in biological systems due to the dysregulation of the redox balance, caused by a deficiency of antioxidants and/or the overproduction of free radicals. Free radical attack against lipids, proteins, sugars and nucleic acids leads to the formation of bioproducts whose detection in fluids and tissues represents the currently available method for assessing oxidative/nitrosative damage. Post-mortem and in-vivo studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment (MCI). In addition to their individual role, biomarkers for OS and NS in AD are associated with altered bioenergetics and amyloid-beta (Abeta) metabolism. In this review we discuss the main results obtained in the field of biomarkers of oxidative/nitrosative stress in AD and MCI in humans, in addition to their potential role as a tool for diagnosis, prognosis and treatment efficacy in AD.

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  • Authors+Show Affiliations

    ,

    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

    , , , , ,

    Source

    Ageing research reviews 8:4 2009 Oct pg 285-305

    MeSH

    Alzheimer Disease
    Biomarkers
    Cognition Disorders
    Free Radicals
    Humans
    Oxidative Stress
    Reactive Oxygen Species

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19376275

    Citation

    Mangialasche, Francesca, et al. "Biomarkers of Oxidative and Nitrosative Damage in Alzheimer's Disease and Mild Cognitive Impairment." Ageing Research Reviews, vol. 8, no. 4, 2009, pp. 285-305.
    Mangialasche F, Polidori MC, Monastero R, et al. Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. Ageing Res Rev. 2009;8(4):285-305.
    Mangialasche, F., Polidori, M. C., Monastero, R., Ercolani, S., Camarda, C., Cecchetti, R., & Mecocci, P. (2009). Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. Ageing Research Reviews, 8(4), pp. 285-305. doi:10.1016/j.arr.2009.04.002.
    Mangialasche F, et al. Biomarkers of Oxidative and Nitrosative Damage in Alzheimer's Disease and Mild Cognitive Impairment. Ageing Res Rev. 2009;8(4):285-305. PubMed PMID: 19376275.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. AU - Mangialasche,Francesca, AU - Polidori,M Cristina, AU - Monastero,Roberto, AU - Ercolani,Sara, AU - Camarda,Cecilia, AU - Cecchetti,Roberta, AU - Mecocci,Patrizia, Y1 - 2009/04/17/ PY - 2009/02/20/received PY - 2009/04/07/revised PY - 2009/04/08/accepted PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/10/1/medline SP - 285 EP - 305 JF - Ageing research reviews JO - Ageing Res. Rev. VL - 8 IS - 4 N2 - Alzheimer's disease (AD) is the most common type of dementia in the elderly. Products of oxidative and nitrosative stress (OS and NS, respectively) accumulate with aging, which is the main risk factor for AD. This provides the basis for the involvement of OS and NS in AD pathogenesis. OS and NS occur in biological systems due to the dysregulation of the redox balance, caused by a deficiency of antioxidants and/or the overproduction of free radicals. Free radical attack against lipids, proteins, sugars and nucleic acids leads to the formation of bioproducts whose detection in fluids and tissues represents the currently available method for assessing oxidative/nitrosative damage. Post-mortem and in-vivo studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment (MCI). In addition to their individual role, biomarkers for OS and NS in AD are associated with altered bioenergetics and amyloid-beta (Abeta) metabolism. In this review we discuss the main results obtained in the field of biomarkers of oxidative/nitrosative stress in AD and MCI in humans, in addition to their potential role as a tool for diagnosis, prognosis and treatment efficacy in AD. SN - 1872-9649 UR - https://www.unboundmedicine.com/medline/citation/19376275/Biomarkers_of_oxidative_and_nitrosative_damage_in_Alzheimer's_disease_and_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-1637(09)00021-X DB - PRIME DP - Unbound Medicine ER -