Tags

Type your tag names separated by a space and hit enter

Vitamin D is associated with cognitive function in elders receiving home health services.
J Gerontol A Biol Sci Med Sci. 2009 Aug; 64(8):888-95.JG

Abstract

BACKGROUND

The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function.

METHODS

A cross-sectional investigation of 25(OH)D and cognition was completed in 377 black and 703 non-black (mainly Caucasian) elders (65-99 years) participating in the nutrition and memory in elders study. Participants underwent a comprehensive neuropsychological battery, and 25(OH)D concentrations were obtained.

RESULTS

More than 65% of elders had suboptimal 25(OH)D concentrations (< or =20 ng/mL or < or =50 nmol/L). Approximately 18% were deficient in 25(OH)D (<10 ng/mL or <25 nmol/L). After adjusting for age, sex, race, body mass index, education, center, kidney function, seasonality, physical activity, and alcohol use, 25(OH)D was associated with better performance on trails A (beta = -0.49, p < .03), trails B (beta = -0.73, p < .02), digit symbol (beta = 0.19, p < .001), matrix reasoning (beta = 0.04, p < .02), and block design (beta = 0.07, p < .04) tests. Associations remained after adjustment for homocysteine, apoE4 allele, plasma B vitamins, and multivitamin use (y/n). 25(OH)D concentrations >20 ng/mL were associated with better performance on tests of executive function, including trails A (80.5 vs 95, p < .05), trails B (205s vs 226s, p < .05), matrix reasoning (7.8 vs 7.0, p = .03), and digit symbol (31.5 vs 37, p < .01). There were no associations between 25(OH)D and memory tests. Factor analysis yielded factors for memory, executive function, and attention/processing speed. After adjustment, 25(OH)D was associated with the executive function (beta = 0.01, p < 0.01) and attention/processing speed factors (beta = 0.01, p = .03), but not the memory factor (beta = -0.001, p = 0.65).

CONCLUSIONS

25(OH)D was positively associated with cognitive performance, particularly with measures of executive function in this elderly population.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19377013

Citation

Buell, Jennifer S., et al. "Vitamin D Is Associated With Cognitive Function in Elders Receiving Home Health Services." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 64, no. 8, 2009, pp. 888-95.
Buell JS, Scott TM, Dawson-Hughes B, et al. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci. 2009;64(8):888-95.
Buell, J. S., Scott, T. M., Dawson-Hughes, B., Dallal, G. E., Rosenberg, I. H., Folstein, M. F., & Tucker, K. L. (2009). Vitamin D is associated with cognitive function in elders receiving home health services. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64(8), 888-95. https://doi.org/10.1093/gerona/glp032
Buell JS, et al. Vitamin D Is Associated With Cognitive Function in Elders Receiving Home Health Services. J Gerontol A Biol Sci Med Sci. 2009;64(8):888-95. PubMed PMID: 19377013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D is associated with cognitive function in elders receiving home health services. AU - Buell,Jennifer S, AU - Scott,Tammy M, AU - Dawson-Hughes,Bess, AU - Dallal,Gerard E, AU - Rosenberg,Irwin H, AU - Folstein,Marshal F, AU - Tucker,Katherine L, Y1 - 2009/04/17/ PY - 2009/4/21/entrez PY - 2009/4/21/pubmed PY - 2009/7/31/medline SP - 888 EP - 95 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 64 IS - 8 N2 - BACKGROUND: The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function. METHODS: A cross-sectional investigation of 25(OH)D and cognition was completed in 377 black and 703 non-black (mainly Caucasian) elders (65-99 years) participating in the nutrition and memory in elders study. Participants underwent a comprehensive neuropsychological battery, and 25(OH)D concentrations were obtained. RESULTS: More than 65% of elders had suboptimal 25(OH)D concentrations (< or =20 ng/mL or < or =50 nmol/L). Approximately 18% were deficient in 25(OH)D (<10 ng/mL or <25 nmol/L). After adjusting for age, sex, race, body mass index, education, center, kidney function, seasonality, physical activity, and alcohol use, 25(OH)D was associated with better performance on trails A (beta = -0.49, p < .03), trails B (beta = -0.73, p < .02), digit symbol (beta = 0.19, p < .001), matrix reasoning (beta = 0.04, p < .02), and block design (beta = 0.07, p < .04) tests. Associations remained after adjustment for homocysteine, apoE4 allele, plasma B vitamins, and multivitamin use (y/n). 25(OH)D concentrations >20 ng/mL were associated with better performance on tests of executive function, including trails A (80.5 vs 95, p < .05), trails B (205s vs 226s, p < .05), matrix reasoning (7.8 vs 7.0, p = .03), and digit symbol (31.5 vs 37, p < .01). There were no associations between 25(OH)D and memory tests. Factor analysis yielded factors for memory, executive function, and attention/processing speed. After adjustment, 25(OH)D was associated with the executive function (beta = 0.01, p < 0.01) and attention/processing speed factors (beta = 0.01, p = .03), but not the memory factor (beta = -0.001, p = 0.65). CONCLUSIONS: 25(OH)D was positively associated with cognitive performance, particularly with measures of executive function in this elderly population. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/19377013/Vitamin_D_is_associated_with_cognitive_function_in_elders_receiving_home_health_services_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glp032 DB - PRIME DP - Unbound Medicine ER -