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Chronic periodontitis-human papillomavirus synergy in base of tongue cancers.
Arch Otolaryngol Head Neck Surg. 2009 Apr; 135(4):391-6.AO

Abstract

OBJECTIVE

To assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in patients with base of tongue cancers.

DESIGN

Case-control study using existing patient data.

SETTING

Roswell Park Cancer Institute.

PATIENTS

Thirty patients newly diagnosed with base of tongue squamous cell carcinoma between 1999 and 2005 for whom both tumor samples and periodontal records were available. Patients younger than 21 years, edentulous, immunocompromised, and those with a history of cancer were excluded. Periodontitis history was assessed on the basis of alveolar bone loss (in millimeters) from panoramic radiographs by one examiner who was blinded to cancer status.

MAIN OUTCOME MEASURE

HPV-16 and HPV-18 DNA were identified on paraffin-embedded tumor samples by polymerase chain reaction. Multiple logistic regression was used to estimate odds ratios and 95% confidence intervals.

RESULTS

The prevalence of tumors positive for HPV-16 DNA was 21 of 30 (70%). None of the samples were positive for HPV-18 DNA. Compared with participants with HPV-negative tumors, patients with HPV-positive tumors had significantly higher mean alveolar bone loss (3.90 mm vs 2.85 mm, P = .01). After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold (odds ratio, 3.96; 95% confidence interval, 1.18-13.36) increased risk of HPV-positive tumor status. Number of missing teeth was not associated with tumor HPV status (odds ratio, 0.95; 95% confidence interval, 0.74-1.21).

CONCLUSIONS

Chronic periodontitis may be a significant factor in the natural history of HPV infection in patients with base of tongue cancers. Additional confirmation in larger studies is required.

Authors+Show Affiliations

Department of Oral Diagnostic Sciences, State University of New York at Buffalo, 355 Squire Hall, Buffalo, NY 14214, USA. mtezal@buffalo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19380363

Citation

Tezal, Mine, et al. "Chronic Periodontitis-human Papillomavirus Synergy in Base of Tongue Cancers." Archives of Otolaryngology--head & Neck Surgery, vol. 135, no. 4, 2009, pp. 391-6.
Tezal M, Sullivan Nasca M, Stoler DL, et al. Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. Arch Otolaryngol Head Neck Surg. 2009;135(4):391-6.
Tezal, M., Sullivan Nasca, M., Stoler, D. L., Melendy, T., Hyland, A., Smaldino, P. J., Rigual, N. R., & Loree, T. R. (2009). Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. Archives of Otolaryngology--head & Neck Surgery, 135(4), 391-6. https://doi.org/10.1001/archoto.2009.6
Tezal M, et al. Chronic Periodontitis-human Papillomavirus Synergy in Base of Tongue Cancers. Arch Otolaryngol Head Neck Surg. 2009;135(4):391-6. PubMed PMID: 19380363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic periodontitis-human papillomavirus synergy in base of tongue cancers. AU - Tezal,Mine, AU - Sullivan Nasca,Maureen, AU - Stoler,Daniel L, AU - Melendy,Thomas, AU - Hyland,Andrew, AU - Smaldino,Philip J, AU - Rigual,Nestor R, AU - Loree,Thom R, PY - 2009/4/22/entrez PY - 2009/4/22/pubmed PY - 2009/5/29/medline SP - 391 EP - 6 JF - Archives of otolaryngology--head & neck surgery JO - Arch. Otolaryngol. Head Neck Surg. VL - 135 IS - 4 N2 - OBJECTIVE: To assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in patients with base of tongue cancers. DESIGN: Case-control study using existing patient data. SETTING: Roswell Park Cancer Institute. PATIENTS: Thirty patients newly diagnosed with base of tongue squamous cell carcinoma between 1999 and 2005 for whom both tumor samples and periodontal records were available. Patients younger than 21 years, edentulous, immunocompromised, and those with a history of cancer were excluded. Periodontitis history was assessed on the basis of alveolar bone loss (in millimeters) from panoramic radiographs by one examiner who was blinded to cancer status. MAIN OUTCOME MEASURE: HPV-16 and HPV-18 DNA were identified on paraffin-embedded tumor samples by polymerase chain reaction. Multiple logistic regression was used to estimate odds ratios and 95% confidence intervals. RESULTS: The prevalence of tumors positive for HPV-16 DNA was 21 of 30 (70%). None of the samples were positive for HPV-18 DNA. Compared with participants with HPV-negative tumors, patients with HPV-positive tumors had significantly higher mean alveolar bone loss (3.90 mm vs 2.85 mm, P = .01). After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold (odds ratio, 3.96; 95% confidence interval, 1.18-13.36) increased risk of HPV-positive tumor status. Number of missing teeth was not associated with tumor HPV status (odds ratio, 0.95; 95% confidence interval, 0.74-1.21). CONCLUSIONS: Chronic periodontitis may be a significant factor in the natural history of HPV infection in patients with base of tongue cancers. Additional confirmation in larger studies is required. SN - 1538-361X UR - https://www.unboundmedicine.com/medline/citation/19380363/Chronic_periodontitis_human_papillomavirus_synergy_in_base_of_tongue_cancers_ L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/archoto.2009.6 DB - PRIME DP - Unbound Medicine ER -