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Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome?
J Atten Disord. 2009 Sep; 13(2):117-26.JA

Abstract

OBJECTIVE

This study aims to evaluate ADHD-like symptoms in children with autism spectrum disorder (ASD) based on single-item analysis, as well as the comparison of two ASD subsamples of children with ADHD (ASD+) and without ADHD (ASD-).

METHODS

Participants are 83 children with ASD. Dimensional and categorical aspects of ADHD are evaluated using a diagnostic symptom checklist according to DSM-IV.

RESULTS

Of the sample, 53% fulfill DSM-IV criteria for ADHD. The comparison of the ASD+ and the ASD- samples reveals differences in age and IQ. Correlations of ADHD and PDD show significant results for symptoms of hyperactivity with impairment in communication and for inattention with stereotyped behavior. Item profiles of ADHD symptoms in the ASD+ sample are similar to those in a pure ADHD sample.

CONCLUSION

The results of our study reveal a high phenotypical overlap between ASD and ADHD. The two identified subtypes, inattentive-stereotyped and hyperactive-communication impaired, reflect the DSM classification and may theoretically be a sign of two different neurochemical pathways, a dopaminergic and a serotonergic.

Authors+Show Affiliations

Clinic for Child and Adolescent Psychiatry, University of Cologne, Germany. judith.sinzig@uk-koeln.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19380514

Citation

Sinzig, Judith, et al. "Attention Deficit/hyperactivity Disorder in Children and Adolescents With Autism Spectrum Disorder: Symptom or Syndrome?" Journal of Attention Disorders, vol. 13, no. 2, 2009, pp. 117-26.
Sinzig J, Walter D, Doepfner M. Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome? J Atten Disord. 2009;13(2):117-26.
Sinzig, J., Walter, D., & Doepfner, M. (2009). Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome? Journal of Attention Disorders, 13(2), 117-26. https://doi.org/10.1177/1087054708326261
Sinzig J, Walter D, Doepfner M. Attention Deficit/hyperactivity Disorder in Children and Adolescents With Autism Spectrum Disorder: Symptom or Syndrome. J Atten Disord. 2009;13(2):117-26. PubMed PMID: 19380514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome? AU - Sinzig,Judith, AU - Walter,Daniel, AU - Doepfner,Manfred, Y1 - 2009/04/20/ PY - 2009/4/22/entrez PY - 2009/4/22/pubmed PY - 2009/10/20/medline SP - 117 EP - 26 JF - Journal of attention disorders JO - J Atten Disord VL - 13 IS - 2 N2 - OBJECTIVE: This study aims to evaluate ADHD-like symptoms in children with autism spectrum disorder (ASD) based on single-item analysis, as well as the comparison of two ASD subsamples of children with ADHD (ASD+) and without ADHD (ASD-). METHODS: Participants are 83 children with ASD. Dimensional and categorical aspects of ADHD are evaluated using a diagnostic symptom checklist according to DSM-IV. RESULTS: Of the sample, 53% fulfill DSM-IV criteria for ADHD. The comparison of the ASD+ and the ASD- samples reveals differences in age and IQ. Correlations of ADHD and PDD show significant results for symptoms of hyperactivity with impairment in communication and for inattention with stereotyped behavior. Item profiles of ADHD symptoms in the ASD+ sample are similar to those in a pure ADHD sample. CONCLUSION: The results of our study reveal a high phenotypical overlap between ASD and ADHD. The two identified subtypes, inattentive-stereotyped and hyperactive-communication impaired, reflect the DSM classification and may theoretically be a sign of two different neurochemical pathways, a dopaminergic and a serotonergic. SN - 1087-0547 UR - https://www.unboundmedicine.com/medline/citation/19380514/Attention_deficit/hyperactivity_disorder_in_children_and_adolescents_with_autism_spectrum_disorder:_symptom_or_syndrome L2 - https://journals.sagepub.com/doi/10.1177/1087054708326261?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -