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Staged bilateral deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease.
Acta Neurochir (Wien). 2009 Jun; 151(6):589-94.AN

Abstract

BACKGROUND

Several investigators have described the efficacy and safety of unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) for the treatment of Parkinson's disease (PD). Some patients who underwent unilateral STN DBS required additional surgery on the contralateral side because the unilateral treatment was insufficient. The goal of this study was to assess the efficacy and safety of staged bilateral STN DBS compared to the simultaneous bilateral procedure.

METHODS

Ten patients with medically intractable PD underwent staged bilateral STN DBS, and 12 patients underwent a simultaneous bilateral procedure. Clinical assessments were performed preoperatively and 6 months after the last surgery using the Unified Parkinson's Disease Rating Scale (UPDRS), motor and activity of daily living (ADL) subscores, and Hoehn and Yahr stages.

FINDINGS

Both the staged and simultaneous groups experienced significant improvement in the UPDRS motor and ADL scores, and the Hoehn and Yahr stages. There were no statistical differences between the two groups in the percent improvement in UPDRS scores. The rate of adverse events in the staged group (20%) was less than that of the simultaneous group (42%), although the difference was not statistically significant.

CONCLUSIONS

Both the staged bilateral STN DBS and the simultaneous bilateral procedure are effective and safe treatment options, but the staged bilateral procedure may be regarded as the preferred choice for the treatment of some patients.

Authors+Show Affiliations

Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. nsgtakasyun@msn.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19381434

Citation

Tanei, Takafumi, et al. "Staged Bilateral Deep Brain Stimulation of the Subthalamic Nucleus for the Treatment of Parkinson's Disease." Acta Neurochirurgica, vol. 151, no. 6, 2009, pp. 589-94.
Tanei T, Kajita Y, Kaneoke Y, et al. Staged bilateral deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Acta Neurochir (Wien). 2009;151(6):589-94.
Tanei, T., Kajita, Y., Kaneoke, Y., Takebayashi, S., Nakatsubo, D., & Wakabayashi, T. (2009). Staged bilateral deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Acta Neurochirurgica, 151(6), 589-94. https://doi.org/10.1007/s00701-009-0293-6
Tanei T, et al. Staged Bilateral Deep Brain Stimulation of the Subthalamic Nucleus for the Treatment of Parkinson's Disease. Acta Neurochir (Wien). 2009;151(6):589-94. PubMed PMID: 19381434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Staged bilateral deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. AU - Tanei,Takafumi, AU - Kajita,Yasukazu, AU - Kaneoke,Yoshiki, AU - Takebayashi,Shigenori, AU - Nakatsubo,Daisuke, AU - Wakabayashi,Toshihiko, Y1 - 2009/04/21/ PY - 2009/01/13/received PY - 2009/03/17/accepted PY - 2009/4/22/entrez PY - 2009/4/22/pubmed PY - 2009/9/10/medline SP - 589 EP - 94 JF - Acta neurochirurgica JO - Acta Neurochir (Wien) VL - 151 IS - 6 N2 - BACKGROUND: Several investigators have described the efficacy and safety of unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) for the treatment of Parkinson's disease (PD). Some patients who underwent unilateral STN DBS required additional surgery on the contralateral side because the unilateral treatment was insufficient. The goal of this study was to assess the efficacy and safety of staged bilateral STN DBS compared to the simultaneous bilateral procedure. METHODS: Ten patients with medically intractable PD underwent staged bilateral STN DBS, and 12 patients underwent a simultaneous bilateral procedure. Clinical assessments were performed preoperatively and 6 months after the last surgery using the Unified Parkinson's Disease Rating Scale (UPDRS), motor and activity of daily living (ADL) subscores, and Hoehn and Yahr stages. FINDINGS: Both the staged and simultaneous groups experienced significant improvement in the UPDRS motor and ADL scores, and the Hoehn and Yahr stages. There were no statistical differences between the two groups in the percent improvement in UPDRS scores. The rate of adverse events in the staged group (20%) was less than that of the simultaneous group (42%), although the difference was not statistically significant. CONCLUSIONS: Both the staged bilateral STN DBS and the simultaneous bilateral procedure are effective and safe treatment options, but the staged bilateral procedure may be regarded as the preferred choice for the treatment of some patients. SN - 0942-0940 UR - https://www.unboundmedicine.com/medline/citation/19381434/Staged_bilateral_deep_brain_stimulation_of_the_subthalamic_nucleus_for_the_treatment_of_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00701-009-0293-6 DB - PRIME DP - Unbound Medicine ER -