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Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.
Neurosci Lett. 2009 Mar 13; 452(2):200-3.NL

Abstract

Painful diabetic neuropathy causes hyperalgesia and does not respond to commonly used analgesics such as non-steroidal anti-inflammatory drugs or opioids at doses below those producing disruptive side effects. In the present study, we examined the effect of P2X receptor antagonists, which are known to modulate the pain pathway, on mechanical hyperalgesia in streptozotocin (STZ)-induced diabetic mice. The paw withdrawal frequency measured by von Frey filaments, began to significantly increase 5 days after STZ injection and was maintained for more than 14 days. Intrathecal administration of P2X receptor antagonists (PPADS and TNP-ATP) inhibited the mechanical allodynia in diabetic mice. The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ. These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice.

Authors+Show Affiliations

Department of Neurophysiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19383439

Citation

Migita, Keisuke, et al. "Modulation of P2X Receptors in Dorsal Root Ganglion Neurons of Streptozotocin-induced Diabetic Neuropathy." Neuroscience Letters, vol. 452, no. 2, 2009, pp. 200-3.
Migita K, Moriyama T, Koguchi M, et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. Neurosci Lett. 2009;452(2):200-3.
Migita, K., Moriyama, T., Koguchi, M., Honda, K., Katsuragi, T., Takano, Y., & Ueno, S. (2009). Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. Neuroscience Letters, 452(2), 200-3. https://doi.org/10.1016/j.neulet.2009.01.048
Migita K, et al. Modulation of P2X Receptors in Dorsal Root Ganglion Neurons of Streptozotocin-induced Diabetic Neuropathy. Neurosci Lett. 2009 Mar 13;452(2):200-3. PubMed PMID: 19383439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. AU - Migita,Keisuke, AU - Moriyama,Tomoko, AU - Koguchi,Masako, AU - Honda,Kenji, AU - Katsuragi,Takeshi, AU - Takano,Yukio, AU - Ueno,Shinya, Y1 - 2009/01/23/ PY - 2008/12/15/received PY - 2009/01/16/revised PY - 2009/01/17/accepted PY - 2009/4/23/entrez PY - 2009/4/23/pubmed PY - 2009/6/30/medline SP - 200 EP - 3 JF - Neuroscience letters JO - Neurosci. Lett. VL - 452 IS - 2 N2 - Painful diabetic neuropathy causes hyperalgesia and does not respond to commonly used analgesics such as non-steroidal anti-inflammatory drugs or opioids at doses below those producing disruptive side effects. In the present study, we examined the effect of P2X receptor antagonists, which are known to modulate the pain pathway, on mechanical hyperalgesia in streptozotocin (STZ)-induced diabetic mice. The paw withdrawal frequency measured by von Frey filaments, began to significantly increase 5 days after STZ injection and was maintained for more than 14 days. Intrathecal administration of P2X receptor antagonists (PPADS and TNP-ATP) inhibited the mechanical allodynia in diabetic mice. The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ. These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19383439/Modulation_of_P2X_receptors_in_dorsal_root_ganglion_neurons_of_streptozotocin_induced_diabetic_neuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)00097-4 DB - PRIME DP - Unbound Medicine ER -