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Leptospirosis outbreak in 2005: L.T.M.G. hospital experience.
Indian J Med Microbiol. 2009 Apr-Jun; 27(2):153-5.IJ

Abstract

Nine hundred and forty two serum samples from clinically suspected cases of leptospirosis admitted in Lokmanya Tilak Municipal General Hospital, Mumbai during July-September 2005 were tested by LeptoTek Dri-dot/Leptocheck. One hundred and sixty five positive sera by these tests were sent to I.R.R., Mumbai, for detection of leptospira IgM antibodies by ELISA (PanBio). Eighty seven positive sera were also sent to B.J. Medical College, Pune, for microscopic agglutination test (MAT) for serovar identification. Seropositivity with LeptoTek Dri-dot/Leptocheck was 34.3%. Adults and males predominated. All patients were febrile. The commonest presentation in adults was jaundice (81.4%), followed by oliguria (37.6%). In children, myalgia was commonest (75.6%), followed by conjunctival suffusion (54.7%). IgM ELISA positivity was 69.1% and MAT positivity was 29.9%. Commonest serovar detected in this geographical area was Leptospira icterohaemorrhagiae (42.9%), followed by L. bataviae, L. tarassovi, and L. pomona . Considering at least two of the above three serological tests positive, 127 cases could be diagnosed and only 89.8% of them could be diagnosed by ELISA and rapid test. Therefore, along with rapid serological tests, IgM ELISA should be routinely done for laboratory diagnosis of leptospirosis.

Authors+Show Affiliations

Department of Microbiology, LTM Medical College and General Hospital, Sion, Mumbai, India. drmmathur@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19384041

Citation

Mathur, Meenakshi, et al. "Leptospirosis Outbreak in 2005: L.T.M.G. Hospital Experience." Indian Journal of Medical Microbiology, vol. 27, no. 2, 2009, pp. 153-5.
Mathur M, De A, Turbadkar D. Leptospirosis outbreak in 2005: L.T.M.G. hospital experience. Indian J Med Microbiol. 2009;27(2):153-5.
Mathur, M., De, A., & Turbadkar, D. (2009). Leptospirosis outbreak in 2005: L.T.M.G. hospital experience. Indian Journal of Medical Microbiology, 27(2), 153-5. https://doi.org/10.4103/0255-0857.49431
Mathur M, De A, Turbadkar D. Leptospirosis Outbreak in 2005: L.T.M.G. Hospital Experience. Indian J Med Microbiol. 2009 Apr-Jun;27(2):153-5. PubMed PMID: 19384041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptospirosis outbreak in 2005: L.T.M.G. hospital experience. AU - Mathur,Meenakshi, AU - De,Anuradha, AU - Turbadkar,Dilip, PY - 2009/4/23/entrez PY - 2009/4/23/pubmed PY - 2009/5/23/medline SP - 153 EP - 5 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 27 IS - 2 N2 - Nine hundred and forty two serum samples from clinically suspected cases of leptospirosis admitted in Lokmanya Tilak Municipal General Hospital, Mumbai during July-September 2005 were tested by LeptoTek Dri-dot/Leptocheck. One hundred and sixty five positive sera by these tests were sent to I.R.R., Mumbai, for detection of leptospira IgM antibodies by ELISA (PanBio). Eighty seven positive sera were also sent to B.J. Medical College, Pune, for microscopic agglutination test (MAT) for serovar identification. Seropositivity with LeptoTek Dri-dot/Leptocheck was 34.3%. Adults and males predominated. All patients were febrile. The commonest presentation in adults was jaundice (81.4%), followed by oliguria (37.6%). In children, myalgia was commonest (75.6%), followed by conjunctival suffusion (54.7%). IgM ELISA positivity was 69.1% and MAT positivity was 29.9%. Commonest serovar detected in this geographical area was Leptospira icterohaemorrhagiae (42.9%), followed by L. bataviae, L. tarassovi, and L. pomona . Considering at least two of the above three serological tests positive, 127 cases could be diagnosed and only 89.8% of them could be diagnosed by ELISA and rapid test. Therefore, along with rapid serological tests, IgM ELISA should be routinely done for laboratory diagnosis of leptospirosis. SN - 1998-3646 UR - https://www.unboundmedicine.com/medline/citation/19384041/Leptospirosis_outbreak_in_2005:_L_T_M_G__hospital_experience_ L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2009;volume=27;issue=2;spage=153;epage=155;aulast=Mathur DB - PRIME DP - Unbound Medicine ER -