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Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection.
Transplantation 2009; 87(8):1174-9T

Abstract

BACKGROUND

The impact of using grafts from donor's age less than or equal to 13 years on adult hepatitis C virus (HCV) recipients in terms of survival and HCV recurrence is undefined. To determine if adults undergoing liver transplantation for HCV who receive a graft from a donor age less than or equal to 13 years have similar outcomes to recipients of organs from 18- to 35-year-old donors.

METHODS

Records from adult HCV patients undergoing liver transplantation between April 1998 and April 2004 who received whole grafts from non-HCV donors less than 35 years old after brain death were reviewed. Patients with donor age less than or equal to 13 years (group 1) and 18 to 35 years (group 2) were compared for patient and graft survival, allograft rejection, biliary complications, and HCV recurrence.

RESULTS

Fifty-one HCV patients were analyzed. The two groups were similar except that group 1 donors and recipients were smaller in size. One year patient and graft survival for groups 1 vs. 2 were 93% vs. 94% and 93% vs. 83%, respectively (P=NS). Biliary complications, HCV recurrence, and advanced fibrosis free survival were not significantly different.

CONCLUSION

Whole liver grafts from donors age less than or equal to 13 years can potentially be used in selected size-matched adult HCV patients in the absence of an acceptable pediatric recipient.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19384164

Citation

Ghabril, Marwan, et al. "Liver Transplantation Using Young Pediatric Donor Grafts in Adults With Hepatitis C Infection." Transplantation, vol. 87, no. 8, 2009, pp. 1174-9.
Ghabril M, Dickson RC, Krishna M, et al. Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection. Transplantation. 2009;87(8):1174-9.
Ghabril, M., Dickson, R. C., Krishna, M., Bonatti, H., Aranda-Michel, J., Keaveny, A. P., ... Nguyen, J. H. (2009). Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection. Transplantation, 87(8), pp. 1174-9. doi:10.1097/TP.0b013e31819ea72f.
Ghabril M, et al. Liver Transplantation Using Young Pediatric Donor Grafts in Adults With Hepatitis C Infection. Transplantation. 2009 Apr 27;87(8):1174-9. PubMed PMID: 19384164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection. AU - Ghabril,Marwan, AU - Dickson,Rolland C, AU - Krishna,Murli, AU - Bonatti,Hugo, AU - Aranda-Michel,Jaime, AU - Keaveny,Andrew P, AU - Satyanarayana,Raj, AU - Hewitt,Winston, AU - Hughes,Christopher B, AU - Nguyen,Justin H, PY - 2009/4/23/entrez PY - 2009/4/23/pubmed PY - 2009/5/15/medline SP - 1174 EP - 9 JF - Transplantation JO - Transplantation VL - 87 IS - 8 N2 - BACKGROUND: The impact of using grafts from donor's age less than or equal to 13 years on adult hepatitis C virus (HCV) recipients in terms of survival and HCV recurrence is undefined. To determine if adults undergoing liver transplantation for HCV who receive a graft from a donor age less than or equal to 13 years have similar outcomes to recipients of organs from 18- to 35-year-old donors. METHODS: Records from adult HCV patients undergoing liver transplantation between April 1998 and April 2004 who received whole grafts from non-HCV donors less than 35 years old after brain death were reviewed. Patients with donor age less than or equal to 13 years (group 1) and 18 to 35 years (group 2) were compared for patient and graft survival, allograft rejection, biliary complications, and HCV recurrence. RESULTS: Fifty-one HCV patients were analyzed. The two groups were similar except that group 1 donors and recipients were smaller in size. One year patient and graft survival for groups 1 vs. 2 were 93% vs. 94% and 93% vs. 83%, respectively (P=NS). Biliary complications, HCV recurrence, and advanced fibrosis free survival were not significantly different. CONCLUSION: Whole liver grafts from donors age less than or equal to 13 years can potentially be used in selected size-matched adult HCV patients in the absence of an acceptable pediatric recipient. SN - 1534-6080 UR - https://www.unboundmedicine.com/medline/citation/19384164/Liver_transplantation_using_young_pediatric_donor_grafts_in_adults_with_hepatitis_C_infection_ L2 - http://Insights.ovid.com/pubmed?pmid=19384164 DB - PRIME DP - Unbound Medicine ER -