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Body iron excretion by healthy men and women.
Am J Clin Nutr. 2009 Jun; 89(6):1792-8.AJ

Abstract

BACKGROUND

Iron excretion measured by isotope dilution has been a primary basis for the factorial derivation of recommendations for iron intake, but the results have been available for men only.

OBJECTIVE

The objective of this study was to confirm iron excretion measurements in healthy men and extend them to women.

DESIGN

The turnover rate of 55Fe that had been administered > or =1 y earlier was determined from blood sampled semiannually for up to 3 y from 53 subjects in the community. Body iron was determined from hemoglobin, serum ferritin, and transferrin receptor. Complete menstrual collections were obtained from 13 women.

RESULTS

The total median (range) iron excretion was 1.18 (0.11-2.07) mg/d for 29 men, 1.58 (0.65-4.88) mg/d for 19 menstruating women, and 0.99 (0.86-1.57) for 5 postmenopausal women. When hormonal contraceptive users were omitted, the median for 15 menstruating women increased to 1.66 mg/d. The distribution of iron excretion was normal for the men and postmenopausal women and was highly skewed for the menstruating women; menstrual iron accounted for 90% of the variation. Iron excretion was not strongly related to body weight. Body iron in menstruating women decreased somewhat (by 4.6%) in the men and tended to increase (by 1.5%) during the study.

CONCLUSIONS

The results extend direct iron excretion measurements in men to include similar measurements in women. The results emphasize the wide range of iron excretion in humans, which results in a 40-fold range of requirements for absorbed iron. This trial was registered at clinicaltrials.gov as NCT00755105.

Authors+Show Affiliations

US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA. janetrhunt@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19386738

Citation

Hunt, Janet R., et al. "Body Iron Excretion By Healthy Men and Women." The American Journal of Clinical Nutrition, vol. 89, no. 6, 2009, pp. 1792-8.
Hunt JR, Zito CA, Johnson LK. Body iron excretion by healthy men and women. Am J Clin Nutr. 2009;89(6):1792-8.
Hunt, J. R., Zito, C. A., & Johnson, L. K. (2009). Body iron excretion by healthy men and women. The American Journal of Clinical Nutrition, 89(6), 1792-8. https://doi.org/10.3945/ajcn.2009.27439
Hunt JR, Zito CA, Johnson LK. Body Iron Excretion By Healthy Men and Women. Am J Clin Nutr. 2009;89(6):1792-8. PubMed PMID: 19386738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body iron excretion by healthy men and women. AU - Hunt,Janet R, AU - Zito,Carol Ann, AU - Johnson,LuAnn K, Y1 - 2009/04/22/ PY - 2009/4/24/entrez PY - 2009/4/24/pubmed PY - 2009/6/13/medline SP - 1792 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 89 IS - 6 N2 - BACKGROUND: Iron excretion measured by isotope dilution has been a primary basis for the factorial derivation of recommendations for iron intake, but the results have been available for men only. OBJECTIVE: The objective of this study was to confirm iron excretion measurements in healthy men and extend them to women. DESIGN: The turnover rate of 55Fe that had been administered > or =1 y earlier was determined from blood sampled semiannually for up to 3 y from 53 subjects in the community. Body iron was determined from hemoglobin, serum ferritin, and transferrin receptor. Complete menstrual collections were obtained from 13 women. RESULTS: The total median (range) iron excretion was 1.18 (0.11-2.07) mg/d for 29 men, 1.58 (0.65-4.88) mg/d for 19 menstruating women, and 0.99 (0.86-1.57) for 5 postmenopausal women. When hormonal contraceptive users were omitted, the median for 15 menstruating women increased to 1.66 mg/d. The distribution of iron excretion was normal for the men and postmenopausal women and was highly skewed for the menstruating women; menstrual iron accounted for 90% of the variation. Iron excretion was not strongly related to body weight. Body iron in menstruating women decreased somewhat (by 4.6%) in the men and tended to increase (by 1.5%) during the study. CONCLUSIONS: The results extend direct iron excretion measurements in men to include similar measurements in women. The results emphasize the wide range of iron excretion in humans, which results in a 40-fold range of requirements for absorbed iron. This trial was registered at clinicaltrials.gov as NCT00755105. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19386738/Body_iron_excretion_by_healthy_men_and_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.27439 DB - PRIME DP - Unbound Medicine ER -