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Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study.
Am J Clin Nutr 2009; 89(6):1737-43AJ

Abstract

BACKGROUND

Many studies in humans have related birth weight to lipid profiles in adulthood. Fewer have estimated associations directly attributable to maternal nutrition during pregnancy.

OBJECTIVE

Our objective was to determine whether famine exposure during gestation is associated with a more atherogenic profile in adult offspring.

DESIGN

In 2003-2005, we studied 1) 359 singleton men and women born between January 1945 and March 1946 in clinics in Amsterdam, Rotterdam, and Leiden whose mothers were exposed to the famine during pregnancy; 2) 299 singletons born in the same 3 institutions during 1943 or 1947; and 3) 313 unexposed same-sex siblings of the above individuals. A lipid profile was obtained after an overnight fast.

RESULTS

Female offspring with prenatal famine exposure had a dyslipidemic pattern characterized by elevated total cholesterol (0.26 mmol/L; 95% CI: 0.07, 0.46; P = 0.007), triglycerides (0.17 mmol/L; 95% CI: 0.03, 0.31; P = 0.02), and LDL cholesterol (0.17 mmol/L; 95% CI: -0.01, 0.36; P = 0.06) compared with unexposed offspring. This pattern was not seen in men. The increases in total cholesterol and LDL cholesterol were independent of body mass index, waist circumference, and midthigh circumference. The increase in triglycerides was independent of midthigh circumference but was attenuated with control for either body mass index or waist circumference. There was no evidence for associations within specific gestational windows. No association was observed between prenatal famine exposure and HDL cholesterol in either sex.

CONCLUSION

In women, but not in men, aged approximately 58 y, we observed an association between prenatal undernutrition and elevated total cholesterol concentrations and triglycerides.

Authors+Show Affiliations

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. lumey@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Historical Article
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19386743

Citation

Lumey, L H., et al. "Lipid Profiles in Middle-aged Men and Women After Famine Exposure During Gestation: the Dutch Hunger Winter Families Study." The American Journal of Clinical Nutrition, vol. 89, no. 6, 2009, pp. 1737-43.
Lumey LH, Stein AD, Kahn HS, et al. Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study. Am J Clin Nutr. 2009;89(6):1737-43.
Lumey, L. H., Stein, A. D., Kahn, H. S., & Romijn, J. A. (2009). Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study. The American Journal of Clinical Nutrition, 89(6), pp. 1737-43. doi:10.3945/ajcn.2008.27038.
Lumey LH, et al. Lipid Profiles in Middle-aged Men and Women After Famine Exposure During Gestation: the Dutch Hunger Winter Families Study. Am J Clin Nutr. 2009;89(6):1737-43. PubMed PMID: 19386743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study. AU - Lumey,L H, AU - Stein,Aryeh D, AU - Kahn,Henry S, AU - Romijn,J A, Y1 - 2009/04/22/ PY - 2009/4/24/entrez PY - 2009/4/24/pubmed PY - 2009/6/13/medline SP - 1737 EP - 43 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 89 IS - 6 N2 - BACKGROUND: Many studies in humans have related birth weight to lipid profiles in adulthood. Fewer have estimated associations directly attributable to maternal nutrition during pregnancy. OBJECTIVE: Our objective was to determine whether famine exposure during gestation is associated with a more atherogenic profile in adult offspring. DESIGN: In 2003-2005, we studied 1) 359 singleton men and women born between January 1945 and March 1946 in clinics in Amsterdam, Rotterdam, and Leiden whose mothers were exposed to the famine during pregnancy; 2) 299 singletons born in the same 3 institutions during 1943 or 1947; and 3) 313 unexposed same-sex siblings of the above individuals. A lipid profile was obtained after an overnight fast. RESULTS: Female offspring with prenatal famine exposure had a dyslipidemic pattern characterized by elevated total cholesterol (0.26 mmol/L; 95% CI: 0.07, 0.46; P = 0.007), triglycerides (0.17 mmol/L; 95% CI: 0.03, 0.31; P = 0.02), and LDL cholesterol (0.17 mmol/L; 95% CI: -0.01, 0.36; P = 0.06) compared with unexposed offspring. This pattern was not seen in men. The increases in total cholesterol and LDL cholesterol were independent of body mass index, waist circumference, and midthigh circumference. The increase in triglycerides was independent of midthigh circumference but was attenuated with control for either body mass index or waist circumference. There was no evidence for associations within specific gestational windows. No association was observed between prenatal famine exposure and HDL cholesterol in either sex. CONCLUSION: In women, but not in men, aged approximately 58 y, we observed an association between prenatal undernutrition and elevated total cholesterol concentrations and triglycerides. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19386743/Lipid_profiles_in_middle_aged_men_and_women_after_famine_exposure_during_gestation:_the_Dutch_Hunger_Winter_Families_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27038 DB - PRIME DP - Unbound Medicine ER -