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Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes.
Coron Artery Dis 2009; 20(3):225-9CA

Abstract

BACKGROUND

The N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes.

METHODS AND RESULTS

We studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003).

CONCLUSION

Measurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes.

Authors+Show Affiliations

Division of Cardiology, University Hospital P. Giaccone, University of Palermo, Palermo, Italy. g.coppola@unipa.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

19387249

Citation

Coppola, Giuseppe, et al. "Analysis of N-terminal pro-B-type Natriuretic Peptide in Patients With Acute Coronary Syndromes." Coronary Artery Disease, vol. 20, no. 3, 2009, pp. 225-9.
Coppola G, Corrado E, Mulè MC, et al. Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes. Coron Artery Dis. 2009;20(3):225-9.
Coppola, G., Corrado, E., Mulè, M. C., Augugliaro, S., Cucchiara, A., Novo, G., ... Novo, S. (2009). Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes. Coronary Artery Disease, 20(3), pp. 225-9. doi:10.1097/MCA.0b013e32832a19a1.
Coppola G, et al. Analysis of N-terminal pro-B-type Natriuretic Peptide in Patients With Acute Coronary Syndromes. Coron Artery Dis. 2009;20(3):225-9. PubMed PMID: 19387249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes. AU - Coppola,Giuseppe, AU - Corrado,Egle, AU - Mulè,Maria Cristina, AU - Augugliaro,Stefano, AU - Cucchiara,Angela, AU - Novo,Giuseppina, AU - Amoroso,Gisella, AU - Assennato,Pasquale, AU - Hoffmann,Enrico, AU - Vitale,Francesco, AU - Novo,Salvatore, PY - 2009/4/24/entrez PY - 2009/4/24/pubmed PY - 2009/6/6/medline SP - 225 EP - 9 JF - Coronary artery disease JO - Coron. Artery Dis. VL - 20 IS - 3 N2 - BACKGROUND: The N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes. METHODS AND RESULTS: We studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003). CONCLUSION: Measurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes. SN - 1473-5830 UR - https://www.unboundmedicine.com/medline/citation/19387249/Analysis_of_N_terminal_pro_B_type_natriuretic_peptide_in_patients_with_acute_coronary_syndromes_ L2 - http://Insights.ovid.com/pubmed?pmid=19387249 DB - PRIME DP - Unbound Medicine ER -