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Relationships among serum receptor of nuclear factor-kappaB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory.
Menopause 2009 Sep-Oct; 16(5):950-5M

Abstract

OBJECTIVE

The aim of this study was to investigate the correlations among circulating osteoprotegerin (OPG), the receptor activator of nuclear factor-kappaB ligand (RANKL), high-sensitivity C-reactive protein (hsCRP), and bone mineral density (BMD) in healthy postmenopausal women.

METHODS

In a population-based study, highly specific enzyme-linked immunosorbent assay methods were used to evaluate the sera of 382 healthy Iranian postmenopausal women (mean age +/- SD, 58.7 +/- 7.5 y) for RANKL, OPG, hsCRP, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy x-ray absorptiometry.

RESULTS

Circulating levels of OPG (r = 0.30, P < 0.001) and the RANKL/OPG ratio (r = -0.17, P < 0.001) were significantly associated with age. The geometric mean of hsCRP was 1.89 mg/L (SE, 1.05) in the population studied. There was a significant correlation between log(hsCRP) levels and body mass index (BMI; r = 0.36, P < 0.001). Multivariate linear analyses revealed that age (beta = -0.295, P < 0.001), BMI (beta = 0.464, P < 0.001), RANKL (beta = -0.105, P = 0.014), and OPG (beta = 0.098, P = 0.029) were the independent determinants for lumbar BMD (R(2) = 0.35). Age (beta = -0.250, P < 0.001), BMI (beta = 0.486, P < 0.001), and RANKL (beta = -0.110, P = 0.009) were independently correlated with femoral neck BMD (R(2) = 0.36). Age- and BMI-adjusted analysis by quartiles of log-transformed hsCRP did not reveal an association with BMD, serum levels of biochemical markers of bone turnover, RANKL, or OPG.

CONCLUSIONS

The circulating levels of the RANKL/OPG osteoimmunity system have an association with BMD, but subclinical systemic inflammation may not be involved in bone mass in healthy postmenopausal women.

Authors+Show Affiliations

Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Islamic Republic of Iran. inabipour@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19387415

Citation

Nabipour, Iraj, et al. "Relationships Among Serum Receptor of Nuclear factor-kappaB Ligand, Osteoprotegerin, High-sensitivity C-reactive Protein, and Bone Mineral Density in Postmenopausal Women: Osteoimmunity Versus Osteoinflammatory." Menopause (New York, N.Y.), vol. 16, no. 5, 2009, pp. 950-5.
Nabipour I, Larijani B, Vahdat K, et al. Relationships among serum receptor of nuclear factor-kappaB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory. Menopause. 2009;16(5):950-5.
Nabipour, I., Larijani, B., Vahdat, K., Assadi, M., Jafari, S. M., Ahmadi, E., ... Amiri, Z. (2009). Relationships among serum receptor of nuclear factor-kappaB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory. Menopause (New York, N.Y.), 16(5), pp. 950-5. doi:10.1097/gme.0b013e3181a181b8.
Nabipour I, et al. Relationships Among Serum Receptor of Nuclear factor-kappaB Ligand, Osteoprotegerin, High-sensitivity C-reactive Protein, and Bone Mineral Density in Postmenopausal Women: Osteoimmunity Versus Osteoinflammatory. Menopause. 2009;16(5):950-5. PubMed PMID: 19387415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships among serum receptor of nuclear factor-kappaB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory. AU - Nabipour,Iraj, AU - Larijani,Bagher, AU - Vahdat,Katayoun, AU - Assadi,Majid, AU - Jafari,Seyed Mojtaba, AU - Ahmadi,Esmaeil, AU - Movahed,Ali, AU - Moradhaseli,Farzad, AU - Sanjdideh,Zahra, AU - Obeidi,Narges, AU - Amiri,Zahra, PY - 2009/4/24/entrez PY - 2009/4/24/pubmed PY - 2009/12/16/medline SP - 950 EP - 5 JF - Menopause (New York, N.Y.) JO - Menopause VL - 16 IS - 5 N2 - OBJECTIVE: The aim of this study was to investigate the correlations among circulating osteoprotegerin (OPG), the receptor activator of nuclear factor-kappaB ligand (RANKL), high-sensitivity C-reactive protein (hsCRP), and bone mineral density (BMD) in healthy postmenopausal women. METHODS: In a population-based study, highly specific enzyme-linked immunosorbent assay methods were used to evaluate the sera of 382 healthy Iranian postmenopausal women (mean age +/- SD, 58.7 +/- 7.5 y) for RANKL, OPG, hsCRP, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy x-ray absorptiometry. RESULTS: Circulating levels of OPG (r = 0.30, P < 0.001) and the RANKL/OPG ratio (r = -0.17, P < 0.001) were significantly associated with age. The geometric mean of hsCRP was 1.89 mg/L (SE, 1.05) in the population studied. There was a significant correlation between log(hsCRP) levels and body mass index (BMI; r = 0.36, P < 0.001). Multivariate linear analyses revealed that age (beta = -0.295, P < 0.001), BMI (beta = 0.464, P < 0.001), RANKL (beta = -0.105, P = 0.014), and OPG (beta = 0.098, P = 0.029) were the independent determinants for lumbar BMD (R(2) = 0.35). Age (beta = -0.250, P < 0.001), BMI (beta = 0.486, P < 0.001), and RANKL (beta = -0.110, P = 0.009) were independently correlated with femoral neck BMD (R(2) = 0.36). Age- and BMI-adjusted analysis by quartiles of log-transformed hsCRP did not reveal an association with BMD, serum levels of biochemical markers of bone turnover, RANKL, or OPG. CONCLUSIONS: The circulating levels of the RANKL/OPG osteoimmunity system have an association with BMD, but subclinical systemic inflammation may not be involved in bone mass in healthy postmenopausal women. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/19387415/Relationships_among_serum_receptor_of_nuclear_factor_kappaB_ligand_osteoprotegerin_high_sensitivity_C_reactive_protein_and_bone_mineral_density_in_postmenopausal_women:_osteoimmunity_versus_osteoinflammatory_ L2 - http://dx.doi.org/10.1097/gme.0b013e3181a181b8 DB - PRIME DP - Unbound Medicine ER -