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Progestin may modify the effect of low-dose hormone therapy on mammographic breast density.
Climacteric. 2009 Jun; 12(3):240-7.C

Abstract

OBJECTIVES

To evaluate the effect on breast density of two low-dose hormone therapy regimens identical in their estrogen component but different in the progestin.

METHODS

A total of 81 non-hysterectomized postmenopausal women were allocated either to 17beta-estradiol 1 mg and norethisterone acetate 0.5 mg (E2/NETA, n = 43) or to 17beta-estradiol 1 mg and drospirenone 2 mg (E2/DRSP, n = 38). Treatment was continuous and lasted 12 months. The main outcomes were the changes in breast density according to the Wolfe classification between baseline and 12-month mammograms.

RESULTS

Involution of the fibroglandular tissue was not seen in either of the treatment groups. Under E2/NETA, breast density increased in seven women (16.3%). In contrast, only three women (7.9%) exhibited a density increase under E2/DRSP.

CONCLUSIONS

Although hormone therapy appears to suspend breast involution, it does not increase breast density in the majority of treated women. Progestins differing in pharmacological properties may have a variable impact on breast density.

Authors+Show Affiliations

2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19387881

Citation

Panoulis, C, et al. "Progestin May Modify the Effect of Low-dose Hormone Therapy On Mammographic Breast Density." Climacteric : the Journal of the International Menopause Society, vol. 12, no. 3, 2009, pp. 240-7.
Panoulis C, Lambrinoudaki I, Vourtsi A, et al. Progestin may modify the effect of low-dose hormone therapy on mammographic breast density. Climacteric. 2009;12(3):240-7.
Panoulis, C., Lambrinoudaki, I., Vourtsi, A., Augoulea, A., Kaparos, G., Aravantinos, L., Christodoulakos, G., & Creatsas, G. (2009). Progestin may modify the effect of low-dose hormone therapy on mammographic breast density. Climacteric : the Journal of the International Menopause Society, 12(3), 240-7. https://doi.org/10.1080/13697130802684601
Panoulis C, et al. Progestin May Modify the Effect of Low-dose Hormone Therapy On Mammographic Breast Density. Climacteric. 2009;12(3):240-7. PubMed PMID: 19387881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progestin may modify the effect of low-dose hormone therapy on mammographic breast density. AU - Panoulis,C, AU - Lambrinoudaki,I, AU - Vourtsi,A, AU - Augoulea,A, AU - Kaparos,G, AU - Aravantinos,L, AU - Christodoulakos,G, AU - Creatsas,G, PY - 2009/4/24/entrez PY - 2009/4/24/pubmed PY - 2009/8/21/medline SP - 240 EP - 7 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 12 IS - 3 N2 - OBJECTIVES: To evaluate the effect on breast density of two low-dose hormone therapy regimens identical in their estrogen component but different in the progestin. METHODS: A total of 81 non-hysterectomized postmenopausal women were allocated either to 17beta-estradiol 1 mg and norethisterone acetate 0.5 mg (E2/NETA, n = 43) or to 17beta-estradiol 1 mg and drospirenone 2 mg (E2/DRSP, n = 38). Treatment was continuous and lasted 12 months. The main outcomes were the changes in breast density according to the Wolfe classification between baseline and 12-month mammograms. RESULTS: Involution of the fibroglandular tissue was not seen in either of the treatment groups. Under E2/NETA, breast density increased in seven women (16.3%). In contrast, only three women (7.9%) exhibited a density increase under E2/DRSP. CONCLUSIONS: Although hormone therapy appears to suspend breast involution, it does not increase breast density in the majority of treated women. Progestins differing in pharmacological properties may have a variable impact on breast density. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/19387881/Progestin_may_modify_the_effect_of_low_dose_hormone_therapy_on_mammographic_breast_density_ L2 - http://www.tandfonline.com/doi/full/10.1080/13697130802684601 DB - PRIME DP - Unbound Medicine ER -