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[Does diet affect our mood? The significance of folic acid and homocysteine].

Abstract

In recent years, there has been growing interest in the association between national diet and the possibility of developing various mental disorders, as well as between deficiency of such vitamins as, e.g. folic acid, vitamin B12, B6, and others (e.g., omega-3 fatty acids), elevated serum homocysteine level and the functioning of human brain as well as the occurrence of such disorders as dementia, central nervous system vascular disorders and depression.

THE AIM OF THE STUDY

was to present the current state of knowledge about the role of folic acid and homocysteine in the human organism as well as the significance of vitamin deficiency, mainly folic acid and hyperhomocysteinemy for the occurrence of mood disorders.

METHOD

The authors conducted the search of the Internet database Medline (www.pubmed.com) using as key words: depression, mood, homocysteine, vitamin deficiencies: folic acid, B6 and 812 and time descriptors: 1990-2007.

RESULTS

In depression, folate, vitamins B12 and B6, as well as unsaturated omega-3 fatty acids deficiency affects the biochemical processes in the CNS, as folic acid and vitamin B12, participate in the metabolism of S-adenosylmethionine (SAM), a donator of methyl groups, which play a decisive role in the functioning of the nervous system; they are, among others, active in the formation of neurotransmitters (e.g. serotonin), phospholipids that are a component of neuronal myelin sheaths, and cell receptors. The deficiency of the vitamins in question results in hyperhomocysteinemia (the research shows that approximately 45-55% of patients with depression develop significantly elevated serum homocysteine), which causes a decrease in SAM, followed by impaired methylation and, consequently, impaired metabolism of neurotransmitters, phospholipids, myelin, and receptors. Hyperhomocysteinemia also leads to activation of NMDA receptors, lesions in vascular endothelium, and oxidative stress. All this effects neurotoxicity and promotes the development of various disorders, including depression. Vitamins B12 and B6, folic acid and omega-3 fatty acids supplementation is thus important in patients suffering from their deficiency; national diet as a significant factor in prevention of numerous CNS disorders, including depression, is also worth consideration.

Authors+Show Affiliations

,

Medical University of Lublin, The Department of Psychiatry, Poland. karakulahw@cyberia.pl

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Source

MeSH

Affect
Dietary Supplements
Folic Acid
Folic Acid Deficiency
Homocysteine
Humans
Mood Disorders
Vitamin B 12
Vitamin B 12 Deficiency
Vitamin B 6
Vitamin B 6 Deficiency

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

19388520

Citation

Karakuła, Hanna, et al. "[Does Diet Affect Our Mood? the Significance of Folic Acid and Homocysteine]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 26, no. 152, 2009, pp. 136-41.
Karakuła H, Opolska A, Kowal A, et al. [Does diet affect our mood? The significance of folic acid and homocysteine]. Pol Merkur Lekarski. 2009;26(152):136-41.
Karakuła, H., Opolska, A., Kowal, A., Domański, M., Płotka, A., & Perzyński, J. (2009). [Does diet affect our mood? The significance of folic acid and homocysteine]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 26(152), pp. 136-41.
Karakuła H, et al. [Does Diet Affect Our Mood? the Significance of Folic Acid and Homocysteine]. Pol Merkur Lekarski. 2009;26(152):136-41. PubMed PMID: 19388520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Does diet affect our mood? The significance of folic acid and homocysteine]. AU - Karakuła,Hanna, AU - Opolska,Aneta, AU - Kowal,Anna, AU - Domański,Maciej, AU - Płotka,Aniela, AU - Perzyński,Janusz, PY - 2009/4/25/entrez PY - 2009/4/25/pubmed PY - 2009/5/13/medline SP - 136 EP - 41 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 26 IS - 152 N2 - UNLABELLED: In recent years, there has been growing interest in the association between national diet and the possibility of developing various mental disorders, as well as between deficiency of such vitamins as, e.g. folic acid, vitamin B12, B6, and others (e.g., omega-3 fatty acids), elevated serum homocysteine level and the functioning of human brain as well as the occurrence of such disorders as dementia, central nervous system vascular disorders and depression. THE AIM OF THE STUDY: was to present the current state of knowledge about the role of folic acid and homocysteine in the human organism as well as the significance of vitamin deficiency, mainly folic acid and hyperhomocysteinemy for the occurrence of mood disorders. METHOD: The authors conducted the search of the Internet database Medline (www.pubmed.com) using as key words: depression, mood, homocysteine, vitamin deficiencies: folic acid, B6 and 812 and time descriptors: 1990-2007. RESULTS: In depression, folate, vitamins B12 and B6, as well as unsaturated omega-3 fatty acids deficiency affects the biochemical processes in the CNS, as folic acid and vitamin B12, participate in the metabolism of S-adenosylmethionine (SAM), a donator of methyl groups, which play a decisive role in the functioning of the nervous system; they are, among others, active in the formation of neurotransmitters (e.g. serotonin), phospholipids that are a component of neuronal myelin sheaths, and cell receptors. The deficiency of the vitamins in question results in hyperhomocysteinemia (the research shows that approximately 45-55% of patients with depression develop significantly elevated serum homocysteine), which causes a decrease in SAM, followed by impaired methylation and, consequently, impaired metabolism of neurotransmitters, phospholipids, myelin, and receptors. Hyperhomocysteinemia also leads to activation of NMDA receptors, lesions in vascular endothelium, and oxidative stress. All this effects neurotoxicity and promotes the development of various disorders, including depression. Vitamins B12 and B6, folic acid and omega-3 fatty acids supplementation is thus important in patients suffering from their deficiency; national diet as a significant factor in prevention of numerous CNS disorders, including depression, is also worth consideration. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/19388520/[Does_diet_affect_our_mood_The_significance_of_folic_acid_and_homocysteine]_ L2 - https://medlineplus.gov/mooddisorders.html DB - PRIME DP - Unbound Medicine ER -