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Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Allergol Int. 2009 Jun; 58(2):277-87.AI

Abstract

BACKGROUND

Recent studies have suggested that allergic rhinitis is closely related to bronchial asthma, reflecting the "one airway-one disease" hypothesis. It is unclear if the effects of pranlukast, a leukotriene-receptor antagonist, are consistent with this hypothesis.

OBJECTIVE

The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season.

METHODS

Patients received fexofenadine hydrochloride plus oral mequitazine (fexofenadine group) or pranlukast hydrate plus oral mequitazine (pranlukast group) as an initial treatment. Subsequent changes in airway responsiveness to acetylcholine were measured.

RESULTS

Among patients in whom coughing developed during the peak pollen season, airway responsiveness significantly increased in the fexofenadine group. In the pranlukast group, airway responsiveness did not increase significantly, regardless of the presence or absence of coughing.

CONCLUSIONS

The results indicate that pranlukast hydrate inhibits airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. In turn, this suggests that cysteinyl leukotrienes have a role in increased airway responsiveness.

Authors+Show Affiliations

Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Tochigi, Japan. h-sagara@dokkyomed.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

19390239

Citation

Sagara, Hironori, et al. "Effects of Pranlukast Hydrate On Airway Hyperresponsiveness in Non-asthmatic Patients With Japanese Cedar Pollinosis." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 58, no. 2, 2009, pp. 277-87.
Sagara H, Yukawa T, Kashima R, et al. Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. Allergol Int. 2009;58(2):277-87.
Sagara, H., Yukawa, T., Kashima, R., Okada, T., & Fukuda, T. (2009). Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. Allergology International : Official Journal of the Japanese Society of Allergology, 58(2), 277-87. https://doi.org/10.2332/allergolint.08-OA-0058
Sagara H, et al. Effects of Pranlukast Hydrate On Airway Hyperresponsiveness in Non-asthmatic Patients With Japanese Cedar Pollinosis. Allergol Int. 2009;58(2):277-87. PubMed PMID: 19390239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. AU - Sagara,Hironori, AU - Yukawa,Tatsuo, AU - Kashima,Ryuichi, AU - Okada,Takenori, AU - Fukuda,Takeshi, Y1 - 2009/04/25/ PY - 2008/10/27/received PY - 2008/12/26/accepted PY - 2009/4/25/entrez PY - 2009/4/25/pubmed PY - 2009/12/16/medline SP - 277 EP - 87 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 58 IS - 2 N2 - BACKGROUND: Recent studies have suggested that allergic rhinitis is closely related to bronchial asthma, reflecting the "one airway-one disease" hypothesis. It is unclear if the effects of pranlukast, a leukotriene-receptor antagonist, are consistent with this hypothesis. OBJECTIVE: The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season. METHODS: Patients received fexofenadine hydrochloride plus oral mequitazine (fexofenadine group) or pranlukast hydrate plus oral mequitazine (pranlukast group) as an initial treatment. Subsequent changes in airway responsiveness to acetylcholine were measured. RESULTS: Among patients in whom coughing developed during the peak pollen season, airway responsiveness significantly increased in the fexofenadine group. In the pranlukast group, airway responsiveness did not increase significantly, regardless of the presence or absence of coughing. CONCLUSIONS: The results indicate that pranlukast hydrate inhibits airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. In turn, this suggests that cysteinyl leukotrienes have a role in increased airway responsiveness. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/19390239/Effects_of_pranlukast_hydrate_on_airway_hyperresponsiveness_in_non_asthmatic_patients_with_Japanese_cedar_pollinosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(15)30707-3 DB - PRIME DP - Unbound Medicine ER -