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Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk.
Aliment Pharmacol Ther. 2009 Jul 01; 30(2):113-25.AP

Abstract

BACKGROUND

In 1980, Garland hypothesized that lower levels of vitamin D resulting from much weaker UV-B radiation at higher latitudes may account for the striking geographical pattern of cancer mortality. Further research has been conducted over the past 20 years.

AIM

To perform a systematic review and meta-analysis of longitudinal studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and the risk of colorectal cancer (CRC).

METHODS

Relevant studies published until September 2008 were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/mL. Summary odds ratios (ORs) were calculated using meta-analysis methods.

RESULTS

Overall, eight original articles reporting on the association between serum 25(OH) D and CRC risk were included. In meta-analyses, summary ORs (95% confidence intervals) for the incidence of CRC, colon cancer and rectal cancer associated with an increase of 25(OH)D by 20 ng/mL were 0.57 (0.43-0.76), 0.78 (0.54-1.13) and 0.41 (0.11-1.49). No indication for publication bias was found.

CONCLUSIONS

Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.

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    Authors+Show Affiliations

    Yin L
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse, Heidelberg D-69115, Germany.
    Grandi N
    No affiliation info available
    Raum E
    No affiliation info available
    Haug U
    No affiliation info available
    Arndt V
    No affiliation info available
    Brenner H
    No affiliation info available

    MeSH

    Clinical Trials as TopicColorectal NeoplasmsEpidemiologic MethodsFemaleHumansMaleRisk FactorsVitamin D

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Systematic Review

    Language

    eng

    PubMed ID

    19392870

    Citation

    Yin, L, et al. "Meta-analysis: Longitudinal Studies of Serum Vitamin D and Colorectal Cancer Risk." Alimentary Pharmacology & Therapeutics, vol. 30, no. 2, 2009, pp. 113-25.
    Yin L, Grandi N, Raum E, et al. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther. 2009;30(2):113-25.
    Yin, L., Grandi, N., Raum, E., Haug, U., Arndt, V., & Brenner, H. (2009). Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Alimentary Pharmacology & Therapeutics, 30(2), 113-25. https://doi.org/10.1111/j.1365-2036.2009.04022.x
    Yin L, et al. Meta-analysis: Longitudinal Studies of Serum Vitamin D and Colorectal Cancer Risk. Aliment Pharmacol Ther. 2009 Jul 1;30(2):113-25. PubMed PMID: 19392870.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. AU - Yin,L, AU - Grandi,N, AU - Raum,E, AU - Haug,U, AU - Arndt,V, AU - Brenner,H, Y1 - 2009/04/15/ PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2010/2/23/medline SP - 113 EP - 25 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 30 IS - 2 N2 - BACKGROUND: In 1980, Garland hypothesized that lower levels of vitamin D resulting from much weaker UV-B radiation at higher latitudes may account for the striking geographical pattern of cancer mortality. Further research has been conducted over the past 20 years. AIM: To perform a systematic review and meta-analysis of longitudinal studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and the risk of colorectal cancer (CRC). METHODS: Relevant studies published until September 2008 were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/mL. Summary odds ratios (ORs) were calculated using meta-analysis methods. RESULTS: Overall, eight original articles reporting on the association between serum 25(OH) D and CRC risk were included. In meta-analyses, summary ORs (95% confidence intervals) for the incidence of CRC, colon cancer and rectal cancer associated with an increase of 25(OH)D by 20 ng/mL were 0.57 (0.43-0.76), 0.78 (0.54-1.13) and 0.41 (0.11-1.49). No indication for publication bias was found. CONCLUSIONS: Our results support suggestions that serum 25(OH)D is inversely related to CRC risk. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19392870/Meta_analysis:_longitudinal_studies_of_serum_vitamin_D_and_colorectal_cancer_risk_ L2 - https://doi.org/10.1111/j.1365-2036.2009.04022.x DB - PRIME DP - Unbound Medicine ER -