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The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis.
Autoimmun Rev 2009; 8(7):621-6AR

Abstract

A poor vitamin D status has been associated with several autoimmune diseases, including multiple sclerosis (MS). The receptor for the biologically active metabolite of vitamin D appears to be a key player in these associations, not only as a mediator of the biological effects of vitamin D, but also as a mediator of the regulation of vitamin D metabolism itself. In this concise review, we will discuss the mostly investigated genetic polymorphisms of the vitamin D receptor (VDR), and their consequences for VDR functionality and immune regulation. Next, we will discuss the association of these polymorphisms with MS, and their relation with vitamin D metabolism. We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS.

Authors+Show Affiliations

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands. j.smolders@mumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19393206

Citation

Smolders, Joost, et al. "The Relevance of Vitamin D Receptor Gene Polymorphisms for Vitamin D Research in Multiple Sclerosis." Autoimmunity Reviews, vol. 8, no. 7, 2009, pp. 621-6.
Smolders J, Peelen E, Thewissen M, et al. The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev. 2009;8(7):621-6.
Smolders, J., Peelen, E., Thewissen, M., Menheere, P., Tervaert, J. W., Hupperts, R., & Damoiseaux, J. (2009). The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmunity Reviews, 8(7), pp. 621-6. doi:10.1016/j.autrev.2009.02.009.
Smolders J, et al. The Relevance of Vitamin D Receptor Gene Polymorphisms for Vitamin D Research in Multiple Sclerosis. Autoimmun Rev. 2009;8(7):621-6. PubMed PMID: 19393206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. AU - Smolders,Joost, AU - Peelen,Evelyn, AU - Thewissen,Mariëlle, AU - Menheere,Paul, AU - Tervaert,Jan Willem Cohen, AU - Hupperts,Raymond, AU - Damoiseaux,Jan, Y1 - 2009/02/11/ PY - 2009/01/08/received PY - 2009/02/06/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/9/12/medline SP - 621 EP - 6 JF - Autoimmunity reviews JO - Autoimmun Rev VL - 8 IS - 7 N2 - A poor vitamin D status has been associated with several autoimmune diseases, including multiple sclerosis (MS). The receptor for the biologically active metabolite of vitamin D appears to be a key player in these associations, not only as a mediator of the biological effects of vitamin D, but also as a mediator of the regulation of vitamin D metabolism itself. In this concise review, we will discuss the mostly investigated genetic polymorphisms of the vitamin D receptor (VDR), and their consequences for VDR functionality and immune regulation. Next, we will discuss the association of these polymorphisms with MS, and their relation with vitamin D metabolism. We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS. SN - 1873-0183 UR - https://www.unboundmedicine.com/medline/citation/19393206/The_relevance_of_vitamin_D_receptor_gene_polymorphisms_for_vitamin_D_research_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(09)00042-1 DB - PRIME DP - Unbound Medicine ER -