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Determination of widely used non-steroidal anti-inflammatory drugs in water samples by in situ derivatization, continuous hollow fiber liquid-phase microextraction and gas chromatography-flame ionization detector.
Anal Chim Acta. 2009 May 08; 641(1-2):83-8.AC

Abstract

The aim of this study was to develop an analytical procedure which allows the quantification of pharmaceuticals in water at the ng L(-1) level. Hence, it is reported research on the application of a rapid, inexpensive and simple continuous hollow fiber liquid-phase micro extraction (CHF-LPME) for the pre-concentration and determination of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (IBP), naproxen (NAP), and ketoprofen (KEP), in wastewater. In this method, a 2.50 cm end sealed piece of a polypropylene hollow fiber was immersed into the organic solvent, octanol, for 30 s. After solvent impregnation with the pores of the fiber, the excess amounts of solvent were removed from inside the fiber, and 4.0 microL of octanol, as the acceptor phase, was injected into the fiber carefully. The fiber was settled using a microsyringe into a 10.0 mL glass test tube, and 20.00 mL of the aqueous solution (the donor phase), was circulated by a pump around it. After analyte extraction for an optimized period of time (20 min), 2 microL of the organic solvent was withdrawn into the microsyringe and injected into the GC-FID for further analysis. Finally, based on the optimized analytical conditions, the method was linear in the range of 2.5-500 ng L(-1). The limits of detection were 1-2 ng L(-1). Repeatability of this method on an intra-day scale was 3.4-10.2% (RSD%). NSAIDs have been detected in several municipal wastewater samples, and the concentration range was 9.0-19.0 ng L(-1).

Authors+Show Affiliations

Department of Chemistry, Faculty of Sciences, Payame Noor University, Iran. zarrin eshaghi@yahoo.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19393370

Citation

Es'haghi, Z. "Determination of Widely Used Non-steroidal Anti-inflammatory Drugs in Water Samples By in Situ Derivatization, Continuous Hollow Fiber Liquid-phase Microextraction and Gas Chromatography-flame Ionization Detector." Analytica Chimica Acta, vol. 641, no. 1-2, 2009, pp. 83-8.
Es'haghi Z. Determination of widely used non-steroidal anti-inflammatory drugs in water samples by in situ derivatization, continuous hollow fiber liquid-phase microextraction and gas chromatography-flame ionization detector. Anal Chim Acta. 2009;641(1-2):83-8.
Es'haghi, Z. (2009). Determination of widely used non-steroidal anti-inflammatory drugs in water samples by in situ derivatization, continuous hollow fiber liquid-phase microextraction and gas chromatography-flame ionization detector. Analytica Chimica Acta, 641(1-2), 83-8. https://doi.org/10.1016/j.aca.2009.03.043
Es'haghi Z. Determination of Widely Used Non-steroidal Anti-inflammatory Drugs in Water Samples By in Situ Derivatization, Continuous Hollow Fiber Liquid-phase Microextraction and Gas Chromatography-flame Ionization Detector. Anal Chim Acta. 2009 May 8;641(1-2):83-8. PubMed PMID: 19393370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of widely used non-steroidal anti-inflammatory drugs in water samples by in situ derivatization, continuous hollow fiber liquid-phase microextraction and gas chromatography-flame ionization detector. A1 - Es'haghi,Z, Y1 - 2009/04/02/ PY - 2008/11/20/received PY - 2009/02/13/revised PY - 2009/03/25/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/7/1/medline SP - 83 EP - 8 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 641 IS - 1-2 N2 - The aim of this study was to develop an analytical procedure which allows the quantification of pharmaceuticals in water at the ng L(-1) level. Hence, it is reported research on the application of a rapid, inexpensive and simple continuous hollow fiber liquid-phase micro extraction (CHF-LPME) for the pre-concentration and determination of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (IBP), naproxen (NAP), and ketoprofen (KEP), in wastewater. In this method, a 2.50 cm end sealed piece of a polypropylene hollow fiber was immersed into the organic solvent, octanol, for 30 s. After solvent impregnation with the pores of the fiber, the excess amounts of solvent were removed from inside the fiber, and 4.0 microL of octanol, as the acceptor phase, was injected into the fiber carefully. The fiber was settled using a microsyringe into a 10.0 mL glass test tube, and 20.00 mL of the aqueous solution (the donor phase), was circulated by a pump around it. After analyte extraction for an optimized period of time (20 min), 2 microL of the organic solvent was withdrawn into the microsyringe and injected into the GC-FID for further analysis. Finally, based on the optimized analytical conditions, the method was linear in the range of 2.5-500 ng L(-1). The limits of detection were 1-2 ng L(-1). Repeatability of this method on an intra-day scale was 3.4-10.2% (RSD%). NSAIDs have been detected in several municipal wastewater samples, and the concentration range was 9.0-19.0 ng L(-1). SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/19393370/Determination_of_widely_used_non_steroidal_anti_inflammatory_drugs_in_water_samples_by_in_situ_derivatization_continuous_hollow_fiber_liquid_phase_microextraction_and_gas_chromatography_flame_ionization_detector_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(09)00477-2 DB - PRIME DP - Unbound Medicine ER -