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Evaluation of principal cannabinoids in airborne particulates.
Anal Chim Acta. 2009 May 08; 641(1-2):89-94.AC

Abstract

The determination of delta(9)-tetrahydrocannabinol (Delta9-THC), cannabidiol (CND) and cannabinol (CNB), primary active components in cannabis preparation, was carried out on airborne particulates by applying a specific procedure consisting of soot extraction by ultrasonic bath, purification by solvent partitioning, derivatization with N-(t-butyldimethylsilyl)-N-methyl-trifluoroacetamide, and separation/detection through gas chromatography coupled with tandem mass spectrometry. The optimized procedure was found suitable for measuring the three psychotropic substances at concentrations ranging from ca. 0.001 to ca. 5.0 ng cm(-3) of air, with recoveries always higher than 82%, accuracy >7.3% and precision >90%. Application of the procedure performed on field in Rome and Bari, Italy, demonstrated that all three compounds contaminate the air in Italian cities whereas in Algiers, Algeria, only cannabinol, the most stable in the atmosphere, exceeded the limit of quantification of the method. The relative percentages of the three cannabinoids in general reproduced those typical of the Cannabis sativa plant and were very different from those found in human blood, urine and sweat.

Authors+Show Affiliations

Italian National Research Council, Institute for Atmospheric Pollution (CNR-IIA), Monterotondo Stazione RM, Italy. balducci@iia.cnr.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19393371

Citation

Balducci, C, et al. "Evaluation of Principal Cannabinoids in Airborne Particulates." Analytica Chimica Acta, vol. 641, no. 1-2, 2009, pp. 89-94.
Balducci C, Nervegna G, Cecinato A. Evaluation of principal cannabinoids in airborne particulates. Anal Chim Acta. 2009;641(1-2):89-94.
Balducci, C., Nervegna, G., & Cecinato, A. (2009). Evaluation of principal cannabinoids in airborne particulates. Analytica Chimica Acta, 641(1-2), 89-94. https://doi.org/10.1016/j.aca.2009.03.037
Balducci C, Nervegna G, Cecinato A. Evaluation of Principal Cannabinoids in Airborne Particulates. Anal Chim Acta. 2009 May 8;641(1-2):89-94. PubMed PMID: 19393371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of principal cannabinoids in airborne particulates. AU - Balducci,C, AU - Nervegna,G, AU - Cecinato,A, Y1 - 2009/03/31/ PY - 2008/12/18/received PY - 2009/03/19/revised PY - 2009/03/23/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/7/1/medline SP - 89 EP - 94 JF - Analytica chimica acta JO - Anal Chim Acta VL - 641 IS - 1-2 N2 - The determination of delta(9)-tetrahydrocannabinol (Delta9-THC), cannabidiol (CND) and cannabinol (CNB), primary active components in cannabis preparation, was carried out on airborne particulates by applying a specific procedure consisting of soot extraction by ultrasonic bath, purification by solvent partitioning, derivatization with N-(t-butyldimethylsilyl)-N-methyl-trifluoroacetamide, and separation/detection through gas chromatography coupled with tandem mass spectrometry. The optimized procedure was found suitable for measuring the three psychotropic substances at concentrations ranging from ca. 0.001 to ca. 5.0 ng cm(-3) of air, with recoveries always higher than 82%, accuracy >7.3% and precision >90%. Application of the procedure performed on field in Rome and Bari, Italy, demonstrated that all three compounds contaminate the air in Italian cities whereas in Algiers, Algeria, only cannabinol, the most stable in the atmosphere, exceeded the limit of quantification of the method. The relative percentages of the three cannabinoids in general reproduced those typical of the Cannabis sativa plant and were very different from those found in human blood, urine and sweat. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/19393371/Evaluation_of_principal_cannabinoids_in_airborne_particulates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(09)00444-9 DB - PRIME DP - Unbound Medicine ER -