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Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats.

Abstract

While Delta(9)-tetrahydrocannabinol (THC) is the main psychoactive constituent of the cannabis plant, a non-psychoactive constituent is cannabidiol (CBD). CBD has been implicated as a potential treatment of a number of disorders including schizophrenia and epilepsy and has been included with THC in a 1:1 combination for the treatment of conditions such as neuropathic pain. This study investigated the effect of THC and CBD, alone or in combination, on some objective behaviours of rats in the open field. Pairs of rats were injected with CBD or vehicle followed by THC or vehicle and behaviour in the open field was assessed for 10 min. In vehicle pretreated rats THC (1 mg/kg) significantly reduced social interaction between rat pairs. Treatment with CBD had no significant effect alone, but pretreatment with CBD (20 mg/kg) reversed the THC-induced decreases in social interaction. A higher dose of THC (10 mg/kg) produced no significant effect on social interaction. However, the combination of high dose CBD and high dose THC significantly reduced social interaction between rat pairs, as well as producing a significant decrease in locomotor activity. This data suggests that CBD can reverse social withdrawal induced by low dose THC, but the combination of high dose THC and CBD impairs social interaction, possibly by decreasing locomotor activity.

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  • Authors+Show Affiliations

    ,

    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Victoria, Australia. daniel.malone@pharm.monash.edu.au

    ,

    Source

    MeSH

    Animals
    Anxiety
    Cannabidiol
    Dronabinol
    Hallucinogens
    Interpersonal Relations
    Linear Models
    Male
    Motor Activity
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19393686

    Citation

    Malone, Daniel Thomas, et al. "Cannabidiol Reverses the Reduction in Social Interaction Produced By Low Dose Delta(9)-tetrahydrocannabinol in Rats." Pharmacology, Biochemistry, and Behavior, vol. 93, no. 2, 2009, pp. 91-6.
    Malone DT, Jongejan D, Taylor DA. Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. Pharmacol Biochem Behav. 2009;93(2):91-6.
    Malone, D. T., Jongejan, D., & Taylor, D. A. (2009). Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. Pharmacology, Biochemistry, and Behavior, 93(2), pp. 91-6. doi:10.1016/j.pbb.2009.04.010.
    Malone DT, Jongejan D, Taylor DA. Cannabidiol Reverses the Reduction in Social Interaction Produced By Low Dose Delta(9)-tetrahydrocannabinol in Rats. Pharmacol Biochem Behav. 2009;93(2):91-6. PubMed PMID: 19393686.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. AU - Malone,Daniel Thomas, AU - Jongejan,Dennis, AU - Taylor,David Alan, Y1 - 2009/04/23/ PY - 2008/10/24/received PY - 2009/04/15/revised PY - 2009/04/16/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/8/29/medline SP - 91 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 93 IS - 2 N2 - While Delta(9)-tetrahydrocannabinol (THC) is the main psychoactive constituent of the cannabis plant, a non-psychoactive constituent is cannabidiol (CBD). CBD has been implicated as a potential treatment of a number of disorders including schizophrenia and epilepsy and has been included with THC in a 1:1 combination for the treatment of conditions such as neuropathic pain. This study investigated the effect of THC and CBD, alone or in combination, on some objective behaviours of rats in the open field. Pairs of rats were injected with CBD or vehicle followed by THC or vehicle and behaviour in the open field was assessed for 10 min. In vehicle pretreated rats THC (1 mg/kg) significantly reduced social interaction between rat pairs. Treatment with CBD had no significant effect alone, but pretreatment with CBD (20 mg/kg) reversed the THC-induced decreases in social interaction. A higher dose of THC (10 mg/kg) produced no significant effect on social interaction. However, the combination of high dose CBD and high dose THC significantly reduced social interaction between rat pairs, as well as producing a significant decrease in locomotor activity. This data suggests that CBD can reverse social withdrawal induced by low dose THC, but the combination of high dose THC and CBD impairs social interaction, possibly by decreasing locomotor activity. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/19393686/Cannabidiol_reverses_the_reduction_in_social_interaction_produced_by_low_dose_Delta_9__tetrahydrocannabinol_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(09)00116-6 DB - PRIME DP - Unbound Medicine ER -