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Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.
Biol Psychiatry. 2009 Oct 01; 66(7):708-11.BP

Abstract

BACKGROUND

Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure-related risk.

METHODS

Thirty-five Caucasians (15 with PTSD, stratified for exposure, age, and gender) were selected from a population-representative sample of persons exposed to the attack from which longitudinal data had been collected in four previous waves. Whole blood gene expression and cortisol levels were obtained.

RESULTS

Seventeen probe sets were differentially expressed in PTSD. Identified genes were generally involved in hypothalamic-pituitary-adrenal (HPA) axis, signal transduction, or brain and immune cell function. FKBP5, a modulator of glucocorticoid receptor (GR) sensitivity, showed reduced expression in PTSD, consistent with enhanced GR responsiveness. FKBP5 expression was predicted by cortisol when entered with PTSD severity in regression analysis. Quantitative polymerase chain reaction confirmed significant reductions in FKBP5. Also less expressed in PTSD were STAT5B, a direct inhibitor of GR, and major histocompatibility complex (MHC) Class II.

CONCLUSIONS

Consistent with observations of HPA axis dysfunction in PTSD, several genes involved in glucocorticoid signaling are differentially expressed among those with current PTSD.

Authors+Show Affiliations

Mount Sinai School of Medicine and James J. Peters Veterans Affairs Medical Center, Bronx, New York 10458, USA. rachel.yehuda@va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19393990

Citation

Yehuda, Rachel, et al. "Gene Expression Patterns Associated With Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks." Biological Psychiatry, vol. 66, no. 7, 2009, pp. 708-11.
Yehuda R, Cai G, Golier JA, et al. Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol Psychiatry. 2009;66(7):708-11.
Yehuda, R., Cai, G., Golier, J. A., Sarapas, C., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Holsboer, F., & Buxbaum, J. D. (2009). Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biological Psychiatry, 66(7), 708-11. https://doi.org/10.1016/j.biopsych.2009.02.034
Yehuda R, et al. Gene Expression Patterns Associated With Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks. Biol Psychiatry. 2009 Oct 1;66(7):708-11. PubMed PMID: 19393990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. AU - Yehuda,Rachel, AU - Cai,Guiqing, AU - Golier,Julia A, AU - Sarapas,Casey, AU - Galea,Sandro, AU - Ising,Marcus, AU - Rein,Theo, AU - Schmeidler,James, AU - Müller-Myhsok,Bertram, AU - Holsboer,Florian, AU - Buxbaum,Joseph D, Y1 - 2009/04/25/ PY - 2008/09/30/received PY - 2009/01/28/revised PY - 2009/02/24/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/12/16/medline SP - 708 EP - 11 JF - Biological psychiatry JO - Biol. Psychiatry VL - 66 IS - 7 N2 - BACKGROUND: Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure-related risk. METHODS: Thirty-five Caucasians (15 with PTSD, stratified for exposure, age, and gender) were selected from a population-representative sample of persons exposed to the attack from which longitudinal data had been collected in four previous waves. Whole blood gene expression and cortisol levels were obtained. RESULTS: Seventeen probe sets were differentially expressed in PTSD. Identified genes were generally involved in hypothalamic-pituitary-adrenal (HPA) axis, signal transduction, or brain and immune cell function. FKBP5, a modulator of glucocorticoid receptor (GR) sensitivity, showed reduced expression in PTSD, consistent with enhanced GR responsiveness. FKBP5 expression was predicted by cortisol when entered with PTSD severity in regression analysis. Quantitative polymerase chain reaction confirmed significant reductions in FKBP5. Also less expressed in PTSD were STAT5B, a direct inhibitor of GR, and major histocompatibility complex (MHC) Class II. CONCLUSIONS: Consistent with observations of HPA axis dysfunction in PTSD, several genes involved in glucocorticoid signaling are differentially expressed among those with current PTSD. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/19393990/Gene_expression_patterns_associated_with_posttraumatic_stress_disorder_following_exposure_to_the_World_Trade_Center_attacks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(09)00394-1 DB - PRIME DP - Unbound Medicine ER -