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Serum transferrin receptors: Distribution and diagnostic performance in pre-school children.
Blood Cells Mol Dis. 2009 Sep-Oct; 43(2):163-8.BC

Abstract

Soluble transferrin receptors have gained interest in the field of diagnosing anemias. Reference ranges differ according to the method used for the quantification of sTfR. We aim to explore the distributional properties and diagnostic performance of sTfR in pre-school healthy children as well as in children with beta-thalassemia carriers, iron deficiency with normal hematological phenotype (ID) and iron deficiency anemia (IDA). Circulating sTfR as well as biochemical and hematological indices were determined in 521 pre-school children and four groups (normal children, beta-thalassemia traits, ID and IDA) were formed. Diagnostic performance and distribution of sTfR according to age and in relation to several parameters were evaluated in every group. Three hundred eighty one children (261 normal, 60 beta-thalassemia traits, 44 ID and 16 IDA) aged 1-6 years were included. We found that distribution of sTfR differed significantly among the four groups (Kruskal Wallis p<0.001) with children in the normal group exhibiting lower concentrations compared to all other. A negative correlation between sTfR and age occurred in the normal (beta=-0.12, p<0.001) and the ID groups (beta=-0.13, p=0.035). In the beta-thal and IDA groups sTfR is correlated to HbA(2) (beta=0.34, p=0.001) and ferritin (Spearman's rho=-0.6, p=0.014) respectively. An area under the curve equal to 0.63 was achieved by sTfR in distinguishing between normal and ID children. Sensitivity and specificity were 70.5% and 50% respectively at a cut-off of 2.5 mg/l. Levels of sTfR are negatively correlated to age in pre-school children while dyserythropoietic procedures like beta-thal, ID, and IDA significantly affect them. These findings indicated that the accuracy of sTfR in diagnosing ID from normal children is limited. Standardization will allow the use of formulas that combine sTfR and ferritin which are of greater diagnostic value than sTfR alone.

Authors+Show Affiliations

First Department of Pediatrics, Athens University Medical School, "Aghia Sophia" Children's Hospital Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19394251

Citation

Chouliaras, Giorgos L., et al. "Serum Transferrin Receptors: Distribution and Diagnostic Performance in Pre-school Children." Blood Cells, Molecules & Diseases, vol. 43, no. 2, 2009, pp. 163-8.
Chouliaras GL, Premetis E, Tsiftis G, et al. Serum transferrin receptors: Distribution and diagnostic performance in pre-school children. Blood Cells Mol Dis. 2009;43(2):163-8.
Chouliaras, G. L., Premetis, E., Tsiftis, G., Drosatou, P., Papassotiriou, I., Stamoulakatou, A., & Lycopoulou, L. (2009). Serum transferrin receptors: Distribution and diagnostic performance in pre-school children. Blood Cells, Molecules & Diseases, 43(2), 163-8. https://doi.org/10.1016/j.bcmd.2009.03.007
Chouliaras GL, et al. Serum Transferrin Receptors: Distribution and Diagnostic Performance in Pre-school Children. Blood Cells Mol Dis. 2009 Sep-Oct;43(2):163-8. PubMed PMID: 19394251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum transferrin receptors: Distribution and diagnostic performance in pre-school children. AU - Chouliaras,Giorgos L, AU - Premetis,Evangelos, AU - Tsiftis,George, AU - Drosatou,Panayiota, AU - Papassotiriou,Ioannis, AU - Stamoulakatou,Alexandra, AU - Lycopoulou,Lilia, Y1 - 2009/04/24/ PY - 2009/02/11/received PY - 2009/03/13/revised PY - 2009/03/18/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/10/22/medline SP - 163 EP - 8 JF - Blood cells, molecules & diseases JO - Blood Cells Mol. Dis. VL - 43 IS - 2 N2 - Soluble transferrin receptors have gained interest in the field of diagnosing anemias. Reference ranges differ according to the method used for the quantification of sTfR. We aim to explore the distributional properties and diagnostic performance of sTfR in pre-school healthy children as well as in children with beta-thalassemia carriers, iron deficiency with normal hematological phenotype (ID) and iron deficiency anemia (IDA). Circulating sTfR as well as biochemical and hematological indices were determined in 521 pre-school children and four groups (normal children, beta-thalassemia traits, ID and IDA) were formed. Diagnostic performance and distribution of sTfR according to age and in relation to several parameters were evaluated in every group. Three hundred eighty one children (261 normal, 60 beta-thalassemia traits, 44 ID and 16 IDA) aged 1-6 years were included. We found that distribution of sTfR differed significantly among the four groups (Kruskal Wallis p<0.001) with children in the normal group exhibiting lower concentrations compared to all other. A negative correlation between sTfR and age occurred in the normal (beta=-0.12, p<0.001) and the ID groups (beta=-0.13, p=0.035). In the beta-thal and IDA groups sTfR is correlated to HbA(2) (beta=0.34, p=0.001) and ferritin (Spearman's rho=-0.6, p=0.014) respectively. An area under the curve equal to 0.63 was achieved by sTfR in distinguishing between normal and ID children. Sensitivity and specificity were 70.5% and 50% respectively at a cut-off of 2.5 mg/l. Levels of sTfR are negatively correlated to age in pre-school children while dyserythropoietic procedures like beta-thal, ID, and IDA significantly affect them. These findings indicated that the accuracy of sTfR in diagnosing ID from normal children is limited. Standardization will allow the use of formulas that combine sTfR and ferritin which are of greater diagnostic value than sTfR alone. SN - 1096-0961 UR - https://www.unboundmedicine.com/medline/citation/19394251/Serum_transferrin_receptors:_Distribution_and_diagnostic_performance_in_pre_school_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079-9796(09)00066-7 DB - PRIME DP - Unbound Medicine ER -