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Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress.
J Vet Cardiol. 2009 May; 11 Suppl 1:S41-50.JV

Abstract

OBJECTIVES

To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.

ANIMALS

Seventy-four cats from 1 university hospital were used.

METHODS

Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).

RESULTS

RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.

CONCLUSIONS

Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.

Authors+Show Affiliations

Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK. dconnolly@rvc.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19394286

Citation

Connolly, David J., et al. "Assessment of the Diagnostic Accuracy of Circulating Natriuretic Peptide Concentrations to Distinguish Between Cats With Cardiac and Non-cardiac Causes of Respiratory Distress." Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, vol. 11 Suppl 1, 2009, pp. S41-50.
Connolly DJ, Soares Magalhaes RJ, Fuentes VL, et al. Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. J Vet Cardiol. 2009;11 Suppl 1:S41-50.
Connolly, D. J., Soares Magalhaes, R. J., Fuentes, V. L., Boswood, A., Cole, G., Boag, A., & Syme, H. M. (2009). Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 11 Suppl 1, S41-50. https://doi.org/10.1016/j.jvc.2009.03.001
Connolly DJ, et al. Assessment of the Diagnostic Accuracy of Circulating Natriuretic Peptide Concentrations to Distinguish Between Cats With Cardiac and Non-cardiac Causes of Respiratory Distress. J Vet Cardiol. 2009;11 Suppl 1:S41-50. PubMed PMID: 19394286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. AU - Connolly,David J, AU - Soares Magalhaes,Ricardo J, AU - Fuentes,Virginia Luis, AU - Boswood,Adrian, AU - Cole,Georgina, AU - Boag,Alisdair, AU - Syme,Harriet M, Y1 - 2009/04/25/ PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/6/26/medline SP - S41 EP - 50 JF - Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology JO - J Vet Cardiol VL - 11 Suppl 1 N2 - OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats. ANIMALS: Seventy-four cats from 1 university hospital were used. METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA). RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively. CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test. SN - 1875-0834 UR - https://www.unboundmedicine.com/medline/citation/19394286/Assessment_of_the_diagnostic_accuracy_of_circulating_natriuretic_peptide_concentrations_to_distinguish_between_cats_with_cardiac_and_non_cardiac_causes_of_respiratory_distress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1760-2734(09)00010-1 DB - PRIME DP - Unbound Medicine ER -