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Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men.
Nutrition 2009 Jul-Aug; 25(7-8):753-61N

Abstract

OBJECTIVE

The main objective of this study was to further elucidate the effect of consuming various foods on the development of squamous cell carcinoma (SCC) in three different sections of the esophagus.

METHODS

A total of 343 patients with SCC of the esophagus and 755 cancer-free control subjects were recruited for this study from 1996 to 2005.

RESULTS

We found that intake of vegetables, raw onions/garlic, and fruits are significantly protective against esophageal SSC risk, whereas intake of hot foods can significantly increase its risk. There was a significant inverse relation between the frequency of tea consumption and esophageal SCC risk (P for trend = 0.005), with a 0.5-fold lower risk associated with the intake of unfermented tea (green tea, oolong tea, or jasmine tea). The effects of dietary factors on esophageal SCC were similar in all subsites, with the exception of consumption of coffee. Coffee consumption was more pronounced in having a protective effect in the middle third section compared with the lower third section of the esophagus (adjusted odds ratio 0.4, 95% confidence interval 0.2-0.9), although this protective effect was marginally significant (adjusted odds ratio 0.6, 95% confidence interval 0.4-1.0) against esophageal SCC in all subsites. Our data also suggest that discomfort when eating hot foods may exert a carcinogenic effect by direct contact with the esophageal mucosa and tend to have more harmful effects in the upper than in the lower esophagus. In contrast, vegetables, fruits, and tea with components that are thought to inhibit carcinogenesis by absorbed components affected all subsites similarly.

CONCLUSION

Our results add additional information that certain dietary components may affect carcinogenesis locally and systemically.

Authors+Show Affiliations

Kaohsiung Medical University, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19394796

Citation

Chen, Yu-Kuei, et al. "Food Intake and the Occurrence of Squamous Cell Carcinoma in Different Sections of the Esophagus in Taiwanese Men." Nutrition (Burbank, Los Angeles County, Calif.), vol. 25, no. 7-8, 2009, pp. 753-61.
Chen YK, Lee CH, Wu IC, et al. Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men. Nutrition. 2009;25(7-8):753-61.
Chen, Y. K., Lee, C. H., Wu, I. C., Liu, J. S., Wu, D. C., Lee, J. M., ... Wu, M. T. (2009). Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men. Nutrition (Burbank, Los Angeles County, Calif.), 25(7-8), pp. 753-61. doi:10.1016/j.nut.2009.02.002.
Chen YK, et al. Food Intake and the Occurrence of Squamous Cell Carcinoma in Different Sections of the Esophagus in Taiwanese Men. Nutrition. 2009;25(7-8):753-61. PubMed PMID: 19394796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men. AU - Chen,Yu-Kuei, AU - Lee,Chien-Hung, AU - Wu,I-Chen, AU - Liu,Jia-Sin, AU - Wu,Deng-Chyang, AU - Lee,Jang-Ming, AU - Goan,Yih-Gang, AU - Chou,Shah-Hwa, AU - Huang,Chia-Tsuan, AU - Lee,Chun-Ying, AU - Hung,Hsin-Chia, AU - Yang,Jeng-Fu, AU - Wu,Ming-Tsang, Y1 - 2009/04/25/ PY - 2008/03/13/received PY - 2008/10/21/revised PY - 2009/02/24/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/10/21/medline SP - 753 EP - 61 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 25 IS - 7-8 N2 - OBJECTIVE: The main objective of this study was to further elucidate the effect of consuming various foods on the development of squamous cell carcinoma (SCC) in three different sections of the esophagus. METHODS: A total of 343 patients with SCC of the esophagus and 755 cancer-free control subjects were recruited for this study from 1996 to 2005. RESULTS: We found that intake of vegetables, raw onions/garlic, and fruits are significantly protective against esophageal SSC risk, whereas intake of hot foods can significantly increase its risk. There was a significant inverse relation between the frequency of tea consumption and esophageal SCC risk (P for trend = 0.005), with a 0.5-fold lower risk associated with the intake of unfermented tea (green tea, oolong tea, or jasmine tea). The effects of dietary factors on esophageal SCC were similar in all subsites, with the exception of consumption of coffee. Coffee consumption was more pronounced in having a protective effect in the middle third section compared with the lower third section of the esophagus (adjusted odds ratio 0.4, 95% confidence interval 0.2-0.9), although this protective effect was marginally significant (adjusted odds ratio 0.6, 95% confidence interval 0.4-1.0) against esophageal SCC in all subsites. Our data also suggest that discomfort when eating hot foods may exert a carcinogenic effect by direct contact with the esophageal mucosa and tend to have more harmful effects in the upper than in the lower esophagus. In contrast, vegetables, fruits, and tea with components that are thought to inhibit carcinogenesis by absorbed components affected all subsites similarly. CONCLUSION: Our results add additional information that certain dietary components may affect carcinogenesis locally and systemically. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19394796/Food_intake_and_the_occurrence_of_squamous_cell_carcinoma_in_different_sections_of_the_esophagus_in_Taiwanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(09)00086-0 DB - PRIME DP - Unbound Medicine ER -