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Alcohol consumption and risk of hematologic malignancies.
Ann Epidemiol. 2009 Oct; 19(10):746-53.AE

Abstract

PURPOSE

Limited data suggest that alcohol drinking may have an inverse relation to risk of non-Hodgkin's lymphoma (NHL). Prospective data about alcohol, NHL, and other hematologic malignancies (HM) are sparse.

METHODS

We carried out a cohort study in a multiethnic population of 126,293 adults who supplied baseline information at health examinations. There were subsequent HM diagnoses in 1244 persons. We used Cox proportional hazards models with seven covariates. The role of beverage types was studied by comparing groups with preponderant choices and by studying the role of frequency of drinking beverage types.

RESULTS

Using lifelong abstainers plus infrequent drinkers as referent, adjusted relative risks (95% confidence intervals) for HM follow: less than one drink per day=1.0 (0.9-1.2), one to two drinks per day=0.9 (0.7-1.0), greater than three drinks per day=0.7 (0.6-0.9, p=0.008). For 673 NHL these were 1.2 (1.0-1.5), 0.9 (0.7-1.2), and 0.9 (0.6-1.2). Persons reporting greater than three drinks/day had inverse relations to lymphocytic (n= 146) and myelocytic (n= 169) leukemias, with relative risk of 0.5 (0.2-1.0, p<0.05) for each. No major independent relation was seen for choice of wine, liquor, or beer.

CONCLUSIONS

Alcohol drinking is associated with slightly lower risk of HM, due largely to inverse relations to lymphocytic and myelocytic leukemia.

Authors+Show Affiliations

Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94610, USA. arthur.klatsky@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19394864

Citation

Klatsky, Arthur L., et al. "Alcohol Consumption and Risk of Hematologic Malignancies." Annals of Epidemiology, vol. 19, no. 10, 2009, pp. 746-53.
Klatsky AL, Li Y, Baer D, et al. Alcohol consumption and risk of hematologic malignancies. Ann Epidemiol. 2009;19(10):746-53.
Klatsky, A. L., Li, Y., Baer, D., Armstrong, M. A., Udaltsova, N., & Friedman, G. D. (2009). Alcohol consumption and risk of hematologic malignancies. Annals of Epidemiology, 19(10), 746-53. https://doi.org/10.1016/j.annepidem.2009.03.005
Klatsky AL, et al. Alcohol Consumption and Risk of Hematologic Malignancies. Ann Epidemiol. 2009;19(10):746-53. PubMed PMID: 19394864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of hematologic malignancies. AU - Klatsky,Arthur L, AU - Li,Yan, AU - Baer,David, AU - Armstrong,Mary Anne, AU - Udaltsova,Natalia, AU - Friedman,Gary D, Y1 - 2009/04/25/ PY - 2008/10/08/received PY - 2009/01/15/revised PY - 2009/03/02/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/11/18/medline SP - 746 EP - 53 JF - Annals of epidemiology JO - Ann Epidemiol VL - 19 IS - 10 N2 - PURPOSE: Limited data suggest that alcohol drinking may have an inverse relation to risk of non-Hodgkin's lymphoma (NHL). Prospective data about alcohol, NHL, and other hematologic malignancies (HM) are sparse. METHODS: We carried out a cohort study in a multiethnic population of 126,293 adults who supplied baseline information at health examinations. There were subsequent HM diagnoses in 1244 persons. We used Cox proportional hazards models with seven covariates. The role of beverage types was studied by comparing groups with preponderant choices and by studying the role of frequency of drinking beverage types. RESULTS: Using lifelong abstainers plus infrequent drinkers as referent, adjusted relative risks (95% confidence intervals) for HM follow: less than one drink per day=1.0 (0.9-1.2), one to two drinks per day=0.9 (0.7-1.0), greater than three drinks per day=0.7 (0.6-0.9, p=0.008). For 673 NHL these were 1.2 (1.0-1.5), 0.9 (0.7-1.2), and 0.9 (0.6-1.2). Persons reporting greater than three drinks/day had inverse relations to lymphocytic (n= 146) and myelocytic (n= 169) leukemias, with relative risk of 0.5 (0.2-1.0, p<0.05) for each. No major independent relation was seen for choice of wine, liquor, or beer. CONCLUSIONS: Alcohol drinking is associated with slightly lower risk of HM, due largely to inverse relations to lymphocytic and myelocytic leukemia. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/19394864/Alcohol_consumption_and_risk_of_hematologic_malignancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(09)00076-3 DB - PRIME DP - Unbound Medicine ER -