Tags

Type your tag names separated by a space and hit enter

Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema.
Ophthalmology. 2009 Jun; 116(6):1158-67.O

Abstract

OBJECTIVE

To study the relationship between spectral domain optical coherence tomography (SD-OCT) findings and fluorescein angiography (FA) patterns in patients with diabetic macular edema (DME).

DESIGN

Retrospective, observational, cross-sectional study.

PARTICIPANTS

We included 59 eyes from 59 patients with DME that had SD-OCT/scanning laser ophthalmoscope (SLO) and FA performed on the same day. Eyes with macular edema owing to other ocular diseases were excluded.

METHODS

The relationship between SD-OCT and FA findings was evaluated by superimposing and aligning the SLO images onto the FA photos. The SLO image of the OPKO/OTI Spectral OCT/SLO (OPKO-OTI, Miami, FL) corresponds with the exact origin and orientation of the SD-OCT scan, which was then correlated with the FA image. Foveal and extrafoveal regions were studied separately. Leakage on FA and pathologic changes on OCT were graded by using standard photographs. Pathologic changes studied in the OCT images included edema and cystic spaces in the inner and outer retina, loss of retinal layers, and foveal cysts.

MAIN OUTCOME MEASURES

Correlation between SD-OCT changes and corresponding FA patterns.

RESULTS

The outer retina was the predominant location of fluid in DME. The severity of the outer retinal edema on OCT was positively correlated with the severity of leakage on FA (r = 0.735; P<0.001). Cystic changes in the inner and outer retina were also correlated with the severity of fluorescein leakage (r = 0.507 and P<0.001; r = 0.561 and P<0.001, respectively). Loss of inner retinal layers on OCT was highly correlated with capillary nonperfusion on FA (r = 0.953; P<0.001). Large foveal cysts on SD-OCT corresponded to cystoid leakage patterns on FA.

CONCLUSIONS

Pathologic changes on SD-OCT correlated well with FA findings. Loss of inner retinal layers was specifically correlated with capillary nonperfusion and severe ischemia. Judgment of whether management of DME based on fine retinal structural changes influences clinical outcomes must be reserved pending further investigation with prospective trials.

FINANCIAL DISCLOSURE(S)

Proprietary or commercial disclosure may be found after the references.

Authors+Show Affiliations

Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19395034

Citation

Yeung, Ling, et al. "Correlation Between Spectral Domain Optical Coherence Tomography Findings and Fluorescein Angiography Patterns in Diabetic Macular Edema." Ophthalmology, vol. 116, no. 6, 2009, pp. 1158-67.
Yeung L, Lima VC, Garcia P, et al. Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema. Ophthalmology. 2009;116(6):1158-67.
Yeung, L., Lima, V. C., Garcia, P., Landa, G., & Rosen, R. B. (2009). Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema. Ophthalmology, 116(6), 1158-67. https://doi.org/10.1016/j.ophtha.2008.12.063
Yeung L, et al. Correlation Between Spectral Domain Optical Coherence Tomography Findings and Fluorescein Angiography Patterns in Diabetic Macular Edema. Ophthalmology. 2009;116(6):1158-67. PubMed PMID: 19395034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema. AU - Yeung,Ling, AU - Lima,Verônica Castro, AU - Garcia,Patricia, AU - Landa,Gennady, AU - Rosen,Richard B, Y1 - 2009/04/23/ PY - 2008/08/26/received PY - 2008/12/08/revised PY - 2008/12/29/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/6/19/medline SP - 1158 EP - 67 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 6 N2 - OBJECTIVE: To study the relationship between spectral domain optical coherence tomography (SD-OCT) findings and fluorescein angiography (FA) patterns in patients with diabetic macular edema (DME). DESIGN: Retrospective, observational, cross-sectional study. PARTICIPANTS: We included 59 eyes from 59 patients with DME that had SD-OCT/scanning laser ophthalmoscope (SLO) and FA performed on the same day. Eyes with macular edema owing to other ocular diseases were excluded. METHODS: The relationship between SD-OCT and FA findings was evaluated by superimposing and aligning the SLO images onto the FA photos. The SLO image of the OPKO/OTI Spectral OCT/SLO (OPKO-OTI, Miami, FL) corresponds with the exact origin and orientation of the SD-OCT scan, which was then correlated with the FA image. Foveal and extrafoveal regions were studied separately. Leakage on FA and pathologic changes on OCT were graded by using standard photographs. Pathologic changes studied in the OCT images included edema and cystic spaces in the inner and outer retina, loss of retinal layers, and foveal cysts. MAIN OUTCOME MEASURES: Correlation between SD-OCT changes and corresponding FA patterns. RESULTS: The outer retina was the predominant location of fluid in DME. The severity of the outer retinal edema on OCT was positively correlated with the severity of leakage on FA (r = 0.735; P<0.001). Cystic changes in the inner and outer retina were also correlated with the severity of fluorescein leakage (r = 0.507 and P<0.001; r = 0.561 and P<0.001, respectively). Loss of inner retinal layers on OCT was highly correlated with capillary nonperfusion on FA (r = 0.953; P<0.001). Large foveal cysts on SD-OCT corresponded to cystoid leakage patterns on FA. CONCLUSIONS: Pathologic changes on SD-OCT correlated well with FA findings. Loss of inner retinal layers was specifically correlated with capillary nonperfusion and severe ischemia. Judgment of whether management of DME based on fine retinal structural changes influences clinical outcomes must be reserved pending further investigation with prospective trials. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19395034/Correlation_between_spectral_domain_optical_coherence_tomography_findings_and_fluorescein_angiography_patterns_in_diabetic_macular_edema_ DB - PRIME DP - Unbound Medicine ER -