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Identifying preperimetric functional loss in glaucoma: a blue-on-yellow multifocal visual evoked potentials study.
Ophthalmology. 2009 Jun; 116(6):1134-41.O

Abstract

PURPOSE

To determine the ability of blue-on-yellow multifocal visual evoked potentials (BonY mfVEP) to identify functional loss in preperimetric glaucoma.

DESIGN

Prospective case series.

PARTICIPANTS

Thirty patients with glaucomatous optic discs and normal standard visual fields.

METHODS

All patients underwent BonY mfVEP, dilated optic disc stereophotography, and optical coherence tomography (Fast RNFL protocol). Optic disc photographs were assessed by 2 independent examiners in a masked fashion.

MAIN OUTCOME MEASURES

The mfVEP amplitude asymmetry and latency values were analyzed and compared topographically with findings of disc assessment. Average retinal nerve fiber layer (RNFL) thickness, RNFL asymmetry, and sectors with RNFL thinning were compared between patients with and without mfVEP defects.

RESULTS

Fourteen (46.7%) patients demonstrated significant abnormality on amplitude asymmetry deviation plots of BonY mfVEP. In all 14 cases, the defect was monocular and corresponded to the eye with the worse disc. In 13 of 14 patients, the defect also corresponded to the location of the worst affected rim. Average RNFL thickness of eyes with mfVEP defects was 81.2+/-9.9 microm, significantly lower than that of patients without defects (90+/-10.5 microm; P = 0.035). Mean asymmetry of RNFL (better minus worse eye) also was significantly higher for patients with mfVEP defects compared with those without such defects (9.0+/-6.4 microm vs. 3.0+/-7 microm; P = 0.03). Average latency of both eyes of glaucomatous patients was delayed compared with that of controls, with no difference in latency between worse and better eyes of glaucoma patients. There was no association of latency delay with either the location of disc changes or mfVEP amplitude defects.

CONCLUSIONS

Amplitude asymmetry of the BonY mfVEP seems to be a promising tool to identify functional loss in preperimetric glaucoma.

FINANCIAL DISCLOSURE(S)

Proprietary or commercial disclosure may be found after the references.

Authors+Show Affiliations

Save Sight Institute, University of Sydney, Sydney, Australia. hema@eye.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19395037

Citation

Arvind, Hemamalini, et al. "Identifying Preperimetric Functional Loss in Glaucoma: a Blue-on-yellow Multifocal Visual Evoked Potentials Study." Ophthalmology, vol. 116, no. 6, 2009, pp. 1134-41.
Arvind H, Graham S, Leaney J, et al. Identifying preperimetric functional loss in glaucoma: a blue-on-yellow multifocal visual evoked potentials study. Ophthalmology. 2009;116(6):1134-41.
Arvind, H., Graham, S., Leaney, J., Grigg, J., Goldberg, I., Billson, F., & Klistorner, A. (2009). Identifying preperimetric functional loss in glaucoma: a blue-on-yellow multifocal visual evoked potentials study. Ophthalmology, 116(6), 1134-41. https://doi.org/10.1016/j.ophtha.2008.12.041
Arvind H, et al. Identifying Preperimetric Functional Loss in Glaucoma: a Blue-on-yellow Multifocal Visual Evoked Potentials Study. Ophthalmology. 2009;116(6):1134-41. PubMed PMID: 19395037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identifying preperimetric functional loss in glaucoma: a blue-on-yellow multifocal visual evoked potentials study. AU - Arvind,Hemamalini, AU - Graham,Stuart, AU - Leaney,John, AU - Grigg,John, AU - Goldberg,Ivan, AU - Billson,Frank, AU - Klistorner,Alexander, Y1 - 2009/04/23/ PY - 2008/08/19/received PY - 2008/10/21/revised PY - 2008/12/16/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/6/19/medline SP - 1134 EP - 41 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 6 N2 - PURPOSE: To determine the ability of blue-on-yellow multifocal visual evoked potentials (BonY mfVEP) to identify functional loss in preperimetric glaucoma. DESIGN: Prospective case series. PARTICIPANTS: Thirty patients with glaucomatous optic discs and normal standard visual fields. METHODS: All patients underwent BonY mfVEP, dilated optic disc stereophotography, and optical coherence tomography (Fast RNFL protocol). Optic disc photographs were assessed by 2 independent examiners in a masked fashion. MAIN OUTCOME MEASURES: The mfVEP amplitude asymmetry and latency values were analyzed and compared topographically with findings of disc assessment. Average retinal nerve fiber layer (RNFL) thickness, RNFL asymmetry, and sectors with RNFL thinning were compared between patients with and without mfVEP defects. RESULTS: Fourteen (46.7%) patients demonstrated significant abnormality on amplitude asymmetry deviation plots of BonY mfVEP. In all 14 cases, the defect was monocular and corresponded to the eye with the worse disc. In 13 of 14 patients, the defect also corresponded to the location of the worst affected rim. Average RNFL thickness of eyes with mfVEP defects was 81.2+/-9.9 microm, significantly lower than that of patients without defects (90+/-10.5 microm; P = 0.035). Mean asymmetry of RNFL (better minus worse eye) also was significantly higher for patients with mfVEP defects compared with those without such defects (9.0+/-6.4 microm vs. 3.0+/-7 microm; P = 0.03). Average latency of both eyes of glaucomatous patients was delayed compared with that of controls, with no difference in latency between worse and better eyes of glaucoma patients. There was no association of latency delay with either the location of disc changes or mfVEP amplitude defects. CONCLUSIONS: Amplitude asymmetry of the BonY mfVEP seems to be a promising tool to identify functional loss in preperimetric glaucoma. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19395037/Identifying_preperimetric_functional_loss_in_glaucoma:_a_blue_on_yellow_multifocal_visual_evoked_potentials_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)01341-9 DB - PRIME DP - Unbound Medicine ER -