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Naloxone increases the frequency of pulsatile luteinizing hormone secretion in women with hyperprolactinemia.
J Clin Endocrinol Metab. 1991 Nov; 73(5):1099-105.JC

Abstract

The ability to change the frequency and amplitude of pulsatile GnRH secretion may be an important mechanism in maintaining regular ovulatory cycles. Hyperprolactinemia is associated with anovulation and slow frequency LH (GnRH) secretion in women. To assess whether the slow frequency of LH (GnRH) secretion is due to increased opioid activity, we examined the effect of naloxone infusions in eight amenorrheic hyperprolactinemic women (mean +/- SE, serum PRL, 160 +/- 59 micrograms/L). After a baseline period, either saline or naloxone was infused for 8 h on separate days, and LH was measured in blood obtained at 15-min intervals. Additional samples were obtained for plasma FSH, PRL, estradiol, and progesterone. Responses to exogenous GnRH were assessed at the end of the infusions. LH pulse frequency increased in all subjects from a mean of 4.0 +/- 0.5 pulses/10 h (mean +/- SE) during saline infusion to 8.0 +/- 1.0 pulses/10 h during naloxone infusion (P less than 0.01). LH pulse amplitude did not change, and mean plasma LH increased from 7.4 +/- 0.8 IU/L (+/- SE) to 11.2 +/- 1.5 IU/L during naloxone (P less than 0.01). A small but significant increase was seen in mean plasma FSH. Plasma PRL, estradiol, and progesterone were unchanged by naloxone infusion. These data suggest that elevated serum PRL reduces the frequency of LH (GnRH) secretion by increasing hypothalamic opioid activity and suggest that the anovulation in hyperprolactinemia is consequent upon persistent slow frequency LH (GnRH) secretion.

Authors+Show Affiliations

Department of Internal Medicine, University of Michigan, Ann Arbor 48109.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1939525

Citation

Cook, C B., et al. "Naloxone Increases the Frequency of Pulsatile Luteinizing Hormone Secretion in Women With Hyperprolactinemia." The Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 5, 1991, pp. 1099-105.
Cook CB, Nippoldt TB, Kletter GB, et al. Naloxone increases the frequency of pulsatile luteinizing hormone secretion in women with hyperprolactinemia. J Clin Endocrinol Metab. 1991;73(5):1099-105.
Cook, C. B., Nippoldt, T. B., Kletter, G. B., Kelch, R. P., & Marshall, J. C. (1991). Naloxone increases the frequency of pulsatile luteinizing hormone secretion in women with hyperprolactinemia. The Journal of Clinical Endocrinology and Metabolism, 73(5), 1099-105.
Cook CB, et al. Naloxone Increases the Frequency of Pulsatile Luteinizing Hormone Secretion in Women With Hyperprolactinemia. J Clin Endocrinol Metab. 1991;73(5):1099-105. PubMed PMID: 1939525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naloxone increases the frequency of pulsatile luteinizing hormone secretion in women with hyperprolactinemia. AU - Cook,C B, AU - Nippoldt,T B, AU - Kletter,G B, AU - Kelch,R P, AU - Marshall,J C, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 1099 EP - 105 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 73 IS - 5 N2 - The ability to change the frequency and amplitude of pulsatile GnRH secretion may be an important mechanism in maintaining regular ovulatory cycles. Hyperprolactinemia is associated with anovulation and slow frequency LH (GnRH) secretion in women. To assess whether the slow frequency of LH (GnRH) secretion is due to increased opioid activity, we examined the effect of naloxone infusions in eight amenorrheic hyperprolactinemic women (mean +/- SE, serum PRL, 160 +/- 59 micrograms/L). After a baseline period, either saline or naloxone was infused for 8 h on separate days, and LH was measured in blood obtained at 15-min intervals. Additional samples were obtained for plasma FSH, PRL, estradiol, and progesterone. Responses to exogenous GnRH were assessed at the end of the infusions. LH pulse frequency increased in all subjects from a mean of 4.0 +/- 0.5 pulses/10 h (mean +/- SE) during saline infusion to 8.0 +/- 1.0 pulses/10 h during naloxone infusion (P less than 0.01). LH pulse amplitude did not change, and mean plasma LH increased from 7.4 +/- 0.8 IU/L (+/- SE) to 11.2 +/- 1.5 IU/L during naloxone (P less than 0.01). A small but significant increase was seen in mean plasma FSH. Plasma PRL, estradiol, and progesterone were unchanged by naloxone infusion. These data suggest that elevated serum PRL reduces the frequency of LH (GnRH) secretion by increasing hypothalamic opioid activity and suggest that the anovulation in hyperprolactinemia is consequent upon persistent slow frequency LH (GnRH) secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/1939525/Naloxone_increases_the_frequency_of_pulsatile_luteinizing_hormone_secretion_in_women_with_hyperprolactinemia_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-73-5-1099 DB - PRIME DP - Unbound Medicine ER -