Tags

Type your tag names separated by a space and hit enter

Counterregulatory adaptation to recurrent hypoglycemia in normal humans.
J Clin Endocrinol Metab. 1991 Nov; 73(5):995-1001.JC

Abstract

We evaluated the effect of antecedent hypoglycemia on glucose counterregulation during hypoglycemia in non-diabetic human subjects. In single hypoglycemia studies, glucose production [(3H]3-glucose) and counterregulatory hormone concentrations were measured (after a 3.5-h baseline period of euglycemia) during 120 min of hypoglycemia (glucose clamped at 3.0 mmol/L). During the final 60 min of hypoglycemia, counterregulation resulted in significant increments in glucose production (12.88 +/- 0.83 mumol/kg.min), and plasma glucagon (IRG; 185 +/- 22 ng/L), GH (29.3 +/- 7.0 micrograms/L), cortisol (630 +/- 100 nmol/L), epinephrine (3.44 +/- 0.76 nmol/L), and norepinephrine (2.02 +/- 0.21 nmol/L). In the recurrent hypoglycemia experiment, an antecedent period of identical hypoglycemia was induced. Glucose counterregulation during the second of two periods of hypoglycemia (HYPO 2) was then compared to that in single hypoglycemia studies. During HYPO 2, there were decreased responses in Ra (by 32%; P less than 0.03), GH (by 67%; P less than 0.05), F (by 41%; P less than 0.03), and norepinephrine (by 20%; P = 0.03) compared to those in the single hypoglycemia study. In contrast, plasma IRG values were similar in the single hypoglycemia studies and HYPO 2, but were reduced relative to those during the first hypoglycemic period of recurrent hypoglycemia (IRG, 263 +/- 18 ng/L; P less than 0.025 vs. HYPO 2 and P less than 0.05 vs. single hypoglycemia). Our results suggest that 1) antecedent hypoglycemia may alter glucose counterregulation during hypoglycemia; and 2) recurrent hypoglycemia may result in alterations in reduction of hepatic glucose production.

Authors+Show Affiliations

Davis MR
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Shamoon H
No affiliation info available

MeSH

AcclimatizationAdultBlood GlucoseC-PeptideEpinephrineFemaleGlucagonGlucose Clamp TechniqueGrowth HormoneHumansHydrocortisoneHypoglycemiaInsulinKineticsMaleNorepinephrineReference ValuesTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1939537

Citation

Davis, M R., and H Shamoon. "Counterregulatory Adaptation to Recurrent Hypoglycemia in Normal Humans." The Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 5, 1991, pp. 995-1001.
Davis MR, Shamoon H. Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Metab. 1991;73(5):995-1001.
Davis, M. R., & Shamoon, H. (1991). Counterregulatory adaptation to recurrent hypoglycemia in normal humans. The Journal of Clinical Endocrinology and Metabolism, 73(5), 995-1001.
Davis MR, Shamoon H. Counterregulatory Adaptation to Recurrent Hypoglycemia in Normal Humans. J Clin Endocrinol Metab. 1991;73(5):995-1001. PubMed PMID: 1939537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Counterregulatory adaptation to recurrent hypoglycemia in normal humans. AU - Davis,M R, AU - Shamoon,H, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 995 EP - 1001 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 73 IS - 5 N2 - We evaluated the effect of antecedent hypoglycemia on glucose counterregulation during hypoglycemia in non-diabetic human subjects. In single hypoglycemia studies, glucose production [(3H]3-glucose) and counterregulatory hormone concentrations were measured (after a 3.5-h baseline period of euglycemia) during 120 min of hypoglycemia (glucose clamped at 3.0 mmol/L). During the final 60 min of hypoglycemia, counterregulation resulted in significant increments in glucose production (12.88 +/- 0.83 mumol/kg.min), and plasma glucagon (IRG; 185 +/- 22 ng/L), GH (29.3 +/- 7.0 micrograms/L), cortisol (630 +/- 100 nmol/L), epinephrine (3.44 +/- 0.76 nmol/L), and norepinephrine (2.02 +/- 0.21 nmol/L). In the recurrent hypoglycemia experiment, an antecedent period of identical hypoglycemia was induced. Glucose counterregulation during the second of two periods of hypoglycemia (HYPO 2) was then compared to that in single hypoglycemia studies. During HYPO 2, there were decreased responses in Ra (by 32%; P less than 0.03), GH (by 67%; P less than 0.05), F (by 41%; P less than 0.03), and norepinephrine (by 20%; P = 0.03) compared to those in the single hypoglycemia study. In contrast, plasma IRG values were similar in the single hypoglycemia studies and HYPO 2, but were reduced relative to those during the first hypoglycemic period of recurrent hypoglycemia (IRG, 263 +/- 18 ng/L; P less than 0.025 vs. HYPO 2 and P less than 0.05 vs. single hypoglycemia). Our results suggest that 1) antecedent hypoglycemia may alter glucose counterregulation during hypoglycemia; and 2) recurrent hypoglycemia may result in alterations in reduction of hepatic glucose production. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/1939537/Counterregulatory_adaptation_to_recurrent_hypoglycemia_in_normal_humans_ DB - PRIME DP - Unbound Medicine ER -