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Risk stratification of high-grade prostate cancer treated with antegrade radical prostatectomy with intended wide resection.
Jpn J Clin Oncol. 2009 Jun; 39(6):387-93.JJ

Abstract

OBJECTIVE

The aim of this study was to assess the surgical outcome of high-grade prostate cancer (PCA) treated with antegrade radical prostatectomy with intended wide resection (aRP) and to establish the risk stratification.

METHODS

A consecutive 77 Japanese patients with Gleason score 8-10 PCA were treated with aRP alone and excluding patients with persistently elevated prostate-specific antigen (PSA), prospectively observed without any treatment until PSA failure was confirmed. PSA failure-free, cancer-specific and overall survival curves were generated with Kaplan-Meier method and the difference between groups was assessed with log-rank test. Cox's proportional hazards model was used to elucidate predictors of PSA failure.

RESULTS

During a median follow-up of 6 years, PSA failure was observed in 41 (53%) of the 77 patients. Five- and 10-year PSA failure-free survival rates of the entire cohort were 44.6% and 40.1%, respectively. Both overall and cancer-specific survival rates of the entire cohort at 5 and 10 years were 96.8% and 87.9%, respectively. In a multivariate analysis, PSA (P = 0.008), specimen confinement (SC) (P = 0.006) and persistently elevated PSA after aRP were identified as significant and independent predictors of PSA failure. When stratifying patients into three risk groups according to PSA level and SC status, PSA failure-free survival rate in patients with PSA < 10 ng/ml and specimen-confined disease (SCD) was significantly better than that in those of any other groups.

CONCLUSIONS

Good prognosis can be expected in patients with high-grade PCA treated with aRP alone when PSA < 10 ng/ml and the tumor was removed as an SCD.

Authors+Show Affiliations

Department of Urology, Japanese Foundation for Cancer Research, Cancer Institute Hospital, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan. shinya.yamamoto@jfcr.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19395463

Citation

Yamamoto, Shinya, et al. "Risk Stratification of High-grade Prostate Cancer Treated With Antegrade Radical Prostatectomy With Intended Wide Resection." Japanese Journal of Clinical Oncology, vol. 39, no. 6, 2009, pp. 387-93.
Yamamoto S, Kawakami S, Yonese J, et al. Risk stratification of high-grade prostate cancer treated with antegrade radical prostatectomy with intended wide resection. Jpn J Clin Oncol. 2009;39(6):387-93.
Yamamoto, S., Kawakami, S., Yonese, J., Fujii, Y., Tsukamoto, T., Ohkubo, Y., Komai, Y., Ishikawa, Y., & Fukui, I. (2009). Risk stratification of high-grade prostate cancer treated with antegrade radical prostatectomy with intended wide resection. Japanese Journal of Clinical Oncology, 39(6), 387-93. https://doi.org/10.1093/jjco/hyp032
Yamamoto S, et al. Risk Stratification of High-grade Prostate Cancer Treated With Antegrade Radical Prostatectomy With Intended Wide Resection. Jpn J Clin Oncol. 2009;39(6):387-93. PubMed PMID: 19395463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk stratification of high-grade prostate cancer treated with antegrade radical prostatectomy with intended wide resection. AU - Yamamoto,Shinya, AU - Kawakami,Satoru, AU - Yonese,Junji, AU - Fujii,Yasuhisa, AU - Tsukamoto,Tetsuro, AU - Ohkubo,Yuhei, AU - Komai,Yoshinobu, AU - Ishikawa,Yuichi, AU - Fukui,Iwao, Y1 - 2009/04/24/ PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/7/9/medline SP - 387 EP - 93 JF - Japanese journal of clinical oncology JO - Jpn J Clin Oncol VL - 39 IS - 6 N2 - OBJECTIVE: The aim of this study was to assess the surgical outcome of high-grade prostate cancer (PCA) treated with antegrade radical prostatectomy with intended wide resection (aRP) and to establish the risk stratification. METHODS: A consecutive 77 Japanese patients with Gleason score 8-10 PCA were treated with aRP alone and excluding patients with persistently elevated prostate-specific antigen (PSA), prospectively observed without any treatment until PSA failure was confirmed. PSA failure-free, cancer-specific and overall survival curves were generated with Kaplan-Meier method and the difference between groups was assessed with log-rank test. Cox's proportional hazards model was used to elucidate predictors of PSA failure. RESULTS: During a median follow-up of 6 years, PSA failure was observed in 41 (53%) of the 77 patients. Five- and 10-year PSA failure-free survival rates of the entire cohort were 44.6% and 40.1%, respectively. Both overall and cancer-specific survival rates of the entire cohort at 5 and 10 years were 96.8% and 87.9%, respectively. In a multivariate analysis, PSA (P = 0.008), specimen confinement (SC) (P = 0.006) and persistently elevated PSA after aRP were identified as significant and independent predictors of PSA failure. When stratifying patients into three risk groups according to PSA level and SC status, PSA failure-free survival rate in patients with PSA < 10 ng/ml and specimen-confined disease (SCD) was significantly better than that in those of any other groups. CONCLUSIONS: Good prognosis can be expected in patients with high-grade PCA treated with aRP alone when PSA < 10 ng/ml and the tumor was removed as an SCD. SN - 1465-3621 UR - https://www.unboundmedicine.com/medline/citation/19395463/Risk_stratification_of_high_grade_prostate_cancer_treated_with_antegrade_radical_prostatectomy_with_intended_wide_resection_ L2 - https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyp032 DB - PRIME DP - Unbound Medicine ER -