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Obesity, lifestyle factors, and risk of myelodysplastic syndromes in a large US cohort.
Am J Epidemiol 2009; 169(12):1492-9AJ

Abstract

The etiology of myelodysplastic syndromes (MDS) is not well understood. The authors examined the relations of obesity and lifestyle factors to MDS in a cohort of 471,799 persons aged 50-71 years who were recruited into the National Institutes of Health-AARP Diet and Health Study, a large US prospective study, in 1995-1996. Incident MDS was diagnosed in 193 persons during 2001-2003. A significant positive association was observed between body mass index (BMI; weight (kg)/height (m)(2)) at baseline and MDS. Compared with persons with a BMI less than 25.0, the hazard ratios for persons with BMIs of 25.0-<30.0 and >or=30.0 were 1.15 (95% confidence interval (CI): 0.81, 1.64) and 2.18 (95% CI: 1.51, 3.17; P for trend < 0.001), respectively. The association was not affected by physical activity, cigarette smoking, or alcohol intake. As reported in previous studies, the risk of MDS was elevated among former smokers (hazard ratio = 1.68, 95% CI: 1.17, 2.41) and current smokers (hazard ratio = 3.17, 95% CI: 2.02, 4.98) as compared with never smokers. Physical activity, alcohol consumption, meat intake, and fruit and vegetable intake did not appear to significantly influence the risk of MDS in this analysis. This prospective investigation of MDS implicates both obesity and smoking as modifiable risk factors.

Authors+Show Affiliations

Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut 06520-8034, USA. xiaomei.ma@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19395696

Citation

Ma, Xiaomei, et al. "Obesity, Lifestyle Factors, and Risk of Myelodysplastic Syndromes in a Large US Cohort." American Journal of Epidemiology, vol. 169, no. 12, 2009, pp. 1492-9.
Ma X, Lim U, Park Y, et al. Obesity, lifestyle factors, and risk of myelodysplastic syndromes in a large US cohort. Am J Epidemiol. 2009;169(12):1492-9.
Ma, X., Lim, U., Park, Y., Mayne, S. T., Wang, R., Hartge, P., ... Schatzkin, A. (2009). Obesity, lifestyle factors, and risk of myelodysplastic syndromes in a large US cohort. American Journal of Epidemiology, 169(12), pp. 1492-9. doi:10.1093/aje/kwp074.
Ma X, et al. Obesity, Lifestyle Factors, and Risk of Myelodysplastic Syndromes in a Large US Cohort. Am J Epidemiol. 2009 Jun 15;169(12):1492-9. PubMed PMID: 19395696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, lifestyle factors, and risk of myelodysplastic syndromes in a large US cohort. AU - Ma,Xiaomei, AU - Lim,Unhee, AU - Park,Yikyung, AU - Mayne,Susan T, AU - Wang,Rong, AU - Hartge,Patricia, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, Y1 - 2009/04/24/ PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/6/26/medline SP - 1492 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 169 IS - 12 N2 - The etiology of myelodysplastic syndromes (MDS) is not well understood. The authors examined the relations of obesity and lifestyle factors to MDS in a cohort of 471,799 persons aged 50-71 years who were recruited into the National Institutes of Health-AARP Diet and Health Study, a large US prospective study, in 1995-1996. Incident MDS was diagnosed in 193 persons during 2001-2003. A significant positive association was observed between body mass index (BMI; weight (kg)/height (m)(2)) at baseline and MDS. Compared with persons with a BMI less than 25.0, the hazard ratios for persons with BMIs of 25.0-<30.0 and >or=30.0 were 1.15 (95% confidence interval (CI): 0.81, 1.64) and 2.18 (95% CI: 1.51, 3.17; P for trend < 0.001), respectively. The association was not affected by physical activity, cigarette smoking, or alcohol intake. As reported in previous studies, the risk of MDS was elevated among former smokers (hazard ratio = 1.68, 95% CI: 1.17, 2.41) and current smokers (hazard ratio = 3.17, 95% CI: 2.02, 4.98) as compared with never smokers. Physical activity, alcohol consumption, meat intake, and fruit and vegetable intake did not appear to significantly influence the risk of MDS in this analysis. This prospective investigation of MDS implicates both obesity and smoking as modifiable risk factors. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19395696/Obesity_lifestyle_factors_and_risk_of_myelodysplastic_syndromes_in_a_large_US_cohort_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp074 DB - PRIME DP - Unbound Medicine ER -