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Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.
Molecules. 2009 Apr 24; 14(4):1639-51.M

Abstract

Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer.

Authors+Show Affiliations

Wroclaw University of Technology, Wybrzeze Wyspianskiego, Poland. marcin.drag@pwr.wroc.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19396022

Citation

Drag, Marcin, et al. "Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-resistant Cell Lines." Molecules (Basel, Switzerland), vol. 14, no. 4, 2009, pp. 1639-51.
Drag M, Surowiak P, Drag-Zalesinska M, et al. Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules. 2009;14(4):1639-51.
Drag, M., Surowiak, P., Drag-Zalesinska, M., Dietel, M., Lage, H., & Oleksyszyn, J. (2009). Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules (Basel, Switzerland), 14(4), 1639-51. https://doi.org/10.3390/molecules14041639
Drag M, et al. Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-resistant Cell Lines. Molecules. 2009 Apr 24;14(4):1639-51. PubMed PMID: 19396022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. AU - Drag,Marcin, AU - Surowiak,Pawel, AU - Drag-Zalesinska,Malgorzata, AU - Dietel,Manfred, AU - Lage,Hermann, AU - Oleksyszyn,Józef, Y1 - 2009/04/24/ PY - 2009/03/17/received PY - 2009/04/15/revised PY - 2009/04/22/accepted PY - 2009/4/28/entrez PY - 2009/4/28/pubmed PY - 2009/6/6/medline SP - 1639 EP - 51 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 14 IS - 4 N2 - Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/19396022/Comparision_of_the_cytotoxic_effects_of_birch_bark_extract_betulin_and_betulinic_acid_towards_human_gastric_carcinoma_and_pancreatic_carcinoma_drug_sensitive_and_drug_resistant_cell_lines_ L2 - https://www.mdpi.com/resolver?pii=14041639 DB - PRIME DP - Unbound Medicine ER -