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Post-transcriptional regulation of gene expression in yeast under ethanol stress.
Biotechnol Appl Biochem. 2009 May 06; 53(Pt 2):93-9.BA

Abstract

The selective export of mRNA from the nucleus plays an important role in the regulation of yeast gene expression under ethanol-stressed conditions, and it has been clarified that expression of the transcriptionally activated HSP (heat-shock protein) genes are inhibited in the mRNA processing and export steps. In actual alcoholic fermentation, during the late brewing process for wine in which the ethanol concentration has been increased, the export of bulk poly(A)+ (polyadenylated) mRNA is blocked and protein synthesis is considerably repressed. These observations clearly suggest that variation in the mRNA level is not necessarily reflected in the variation of the protein level in yeast cells during the brewing process. The present minireview outlines the regulation of yeast gene expression at the mRNA-processing and nuclear-export steps under ethanol-stressed conditions, highlighting their usefulness in the brewing industry.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Izawa S
Laboratory of Molecular Microbiology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji city, Kyoto 611-0011, Japan. thioredoxin@kit.ac.jp
Inoue Y
No affiliation info available

MeSH

EthanolGene Expression Regulation, FungalRNA, MessengerSaccharomyces cerevisiaeStress, PhysiologicalTranscription, Genetic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19397495

Citation

Izawa, Shingo, and Yoshiharu Inoue. "Post-transcriptional Regulation of Gene Expression in Yeast Under Ethanol Stress." Biotechnology and Applied Biochemistry, vol. 53, no. Pt 2, 2009, pp. 93-9.
Izawa S, Inoue Y. Post-transcriptional regulation of gene expression in yeast under ethanol stress. Biotechnol Appl Biochem. 2009;53(Pt 2):93-9.
Izawa, S., & Inoue, Y. (2009). Post-transcriptional regulation of gene expression in yeast under ethanol stress. Biotechnology and Applied Biochemistry, 53(Pt 2), 93-9. https://doi.org/10.1042/BA20090036
Izawa S, Inoue Y. Post-transcriptional Regulation of Gene Expression in Yeast Under Ethanol Stress. Biotechnol Appl Biochem. 2009 May 6;53(Pt 2):93-9. PubMed PMID: 19397495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-transcriptional regulation of gene expression in yeast under ethanol stress. AU - Izawa,Shingo, AU - Inoue,Yoshiharu, Y1 - 2009/05/06/ PY - 2009/4/29/entrez PY - 2009/4/29/pubmed PY - 2009/7/7/medline SP - 93 EP - 9 JF - Biotechnology and applied biochemistry JO - Biotechnol Appl Biochem VL - 53 IS - Pt 2 N2 - The selective export of mRNA from the nucleus plays an important role in the regulation of yeast gene expression under ethanol-stressed conditions, and it has been clarified that expression of the transcriptionally activated HSP (heat-shock protein) genes are inhibited in the mRNA processing and export steps. In actual alcoholic fermentation, during the late brewing process for wine in which the ethanol concentration has been increased, the export of bulk poly(A)+ (polyadenylated) mRNA is blocked and protein synthesis is considerably repressed. These observations clearly suggest that variation in the mRNA level is not necessarily reflected in the variation of the protein level in yeast cells during the brewing process. The present minireview outlines the regulation of yeast gene expression at the mRNA-processing and nuclear-export steps under ethanol-stressed conditions, highlighting their usefulness in the brewing industry. SN - 1470-8744 UR - https://www.unboundmedicine.com/medline/citation/19397495/Post_transcriptional_regulation_of_gene_expression_in_yeast_under_ethanol_stress_ L2 - https://doi.org/10.1042/BA20090036 DB - PRIME DP - Unbound Medicine ER -