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Radical hysterectomy for FIGO stage IIB cervical cancer: clinicopathological characteristics and prognostic evaluation.
Gynecol Oncol. 2009 Jul; 114(1):69-74.GO

Abstract

OBJECTIVE

To clarify the clinicopathological features and prognostic factors of patients with FIGO stage IIB cervical cancer who were treated with radical hysterectomy.

METHODS

One hundred thirty-nine FIGO stage IIB patients with squamous or adenosquamous cell carcinoma (median age, 51 years) who were treated with primary radical hysterectomy were examined retrospectively. Sixty-six FIGO stage IIB patients who were treated with primary radiotherapy (median age, 70 years) were included for comparison of survival.

RESULTS

Fifty percent (70/139) of the patients had pathological parametrial involvement. Among them, the positive rate of pelvic lymph nodes was 71% (50/70). Ninety-nine percent (138/139) of the tumors were completely removed, and the pelvic control rate was 88%. Major complications requiring surgery were found in 2.9% (4/139). Significant differences in survival were found among patients in subgroups according to pathological parametrial involvement, pelvic lymph node status, tumor size, lymph-vascular space invasion, and depth of myometrial invasion (log-rank test, P<0.05). Of these, the Cox proportional-hazard model revealed that parametrial involvement (P=0.001, 95% CI 1.992-6.297) and lymph node metastasis (P=0.042, 95% CI 1.023-3.298) were independent prognostic factors. The 5-year survival rate and relapse-free survival at 36 months were 69% and 72% among the radical hysterectomy group, and 69% and 75% among the radiotherapy group. The Cox model adjusted for age showed no significant differences in survival and relapse-free survival between these two groups.

CONCLUSION

Pathological parametrial involvement and positive nodes were prognostic factors for surgically treated patients with FIGO stage IIB cervical cancer.

Authors+Show Affiliations

Division of Gynecology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. takasama@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19398126

Citation

Kasamatsu, Takahiro, et al. "Radical Hysterectomy for FIGO Stage IIB Cervical Cancer: Clinicopathological Characteristics and Prognostic Evaluation." Gynecologic Oncology, vol. 114, no. 1, 2009, pp. 69-74.
Kasamatsu T, Onda T, Sawada M, et al. Radical hysterectomy for FIGO stage IIB cervical cancer: clinicopathological characteristics and prognostic evaluation. Gynecol Oncol. 2009;114(1):69-74.
Kasamatsu, T., Onda, T., Sawada, M., Kato, T., & Ikeda, S. (2009). Radical hysterectomy for FIGO stage IIB cervical cancer: clinicopathological characteristics and prognostic evaluation. Gynecologic Oncology, 114(1), 69-74. https://doi.org/10.1016/j.ygyno.2009.03.026
Kasamatsu T, et al. Radical Hysterectomy for FIGO Stage IIB Cervical Cancer: Clinicopathological Characteristics and Prognostic Evaluation. Gynecol Oncol. 2009;114(1):69-74. PubMed PMID: 19398126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radical hysterectomy for FIGO stage IIB cervical cancer: clinicopathological characteristics and prognostic evaluation. AU - Kasamatsu,Takahiro, AU - Onda,Takashi, AU - Sawada,Morio, AU - Kato,Tomoyasu, AU - Ikeda,Shun-ichi, Y1 - 2009/04/26/ PY - 2009/01/07/received PY - 2009/03/19/revised PY - 2009/03/24/accepted PY - 2009/4/29/entrez PY - 2009/4/29/pubmed PY - 2009/7/9/medline SP - 69 EP - 74 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 114 IS - 1 N2 - OBJECTIVE: To clarify the clinicopathological features and prognostic factors of patients with FIGO stage IIB cervical cancer who were treated with radical hysterectomy. METHODS: One hundred thirty-nine FIGO stage IIB patients with squamous or adenosquamous cell carcinoma (median age, 51 years) who were treated with primary radical hysterectomy were examined retrospectively. Sixty-six FIGO stage IIB patients who were treated with primary radiotherapy (median age, 70 years) were included for comparison of survival. RESULTS: Fifty percent (70/139) of the patients had pathological parametrial involvement. Among them, the positive rate of pelvic lymph nodes was 71% (50/70). Ninety-nine percent (138/139) of the tumors were completely removed, and the pelvic control rate was 88%. Major complications requiring surgery were found in 2.9% (4/139). Significant differences in survival were found among patients in subgroups according to pathological parametrial involvement, pelvic lymph node status, tumor size, lymph-vascular space invasion, and depth of myometrial invasion (log-rank test, P<0.05). Of these, the Cox proportional-hazard model revealed that parametrial involvement (P=0.001, 95% CI 1.992-6.297) and lymph node metastasis (P=0.042, 95% CI 1.023-3.298) were independent prognostic factors. The 5-year survival rate and relapse-free survival at 36 months were 69% and 72% among the radical hysterectomy group, and 69% and 75% among the radiotherapy group. The Cox model adjusted for age showed no significant differences in survival and relapse-free survival between these two groups. CONCLUSION: Pathological parametrial involvement and positive nodes were prognostic factors for surgically treated patients with FIGO stage IIB cervical cancer. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/19398126/Radical_hysterectomy_for_FIGO_stage_IIB_cervical_cancer:_clinicopathological_characteristics_and_prognostic_evaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(09)00197-8 DB - PRIME DP - Unbound Medicine ER -