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Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species.
J Antimicrob Chemother. 2009 Jul; 64(1):73-8.JA

Abstract

OBJECTIVES

The aim of this study was to assess the in vitro activities of nemonoxacin (a novel non-fluorinated quinolone), doripenem, tigecycline and 16 other antimicrobial agents against the Nocardia species.

METHODS

MICs of 19 antimicrobial agents for 125 clinical isolates of the Nocardia species were determined by the broth microdilution method.

RESULTS

Nocardia brasiliensis (n = 61), Nocardia asteroides (n = 45), Nocardia flavorosea (n = 5), Nocardia otitidiscaviarum (n = 4), Nocardia farcinica (n = 3), Nocardia beijingensis (n = 2), Nocardia puris (n = 2) and one each of Nocardia nova, Nocardia jinanensis and Nocardia takedensis were identified based on a 16S rRNA gene sequencing analysis. For N. brasiliensis isolates, the MIC(90)s of the tested quinolones were in the order nemonoxacin < gemifloxacin = moxifloxacin < levofloxacin = ciprofloxacin, and the MIC(90)s of the tested carbapenems were in the order doripenem = meropenem < ertapenem < imipenem. Tigecycline had a lower MIC(90) (1 mg/L) than linezolid (8 mg/L). For N. asteroides isolates, the MIC(90)s of the tested quinolones were in the order nemonoxacin < gemifloxacin = moxifloxacin < levofloxacin < ciprofloxacin, and the MIC(90)s of the tested carbapenems were in the order doripenem = meropenem = imipenem < ertapenem. For the other 19 Nocardia species isolates, nemonoxacin showed good activity with the lowest MIC(90) of the tested quinolones. Among the four tested carbapenems, doripenem and meropenem had comparatively lower MIC(90)s.

CONCLUSIONS

The results of this in vitro study suggest that nemonoxacin, linezolid and tigecycline show promise as treatment options for nocardiosis. Further investigation of their clinical role is warranted.

Authors+Show Affiliations

Department of Internal Medicine, Yi-Min Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19398458

Citation

Lai, Chih-Cheng, et al. "Comparative in Vitro Activities of Nemonoxacin, Doripenem, Tigecycline and 16 Other Antimicrobials Against Nocardia Brasiliensis, Nocardia Asteroides and Unusual Nocardia Species." The Journal of Antimicrobial Chemotherapy, vol. 64, no. 1, 2009, pp. 73-8.
Lai CC, Tan CK, Lin SH, et al. Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species. J Antimicrob Chemother. 2009;64(1):73-8.
Lai, C. C., Tan, C. K., Lin, S. H., Liao, C. H., Chou, C. H., Hsu, H. L., Huang, Y. T., & Hsueh, P. R. (2009). Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species. The Journal of Antimicrobial Chemotherapy, 64(1), 73-8. https://doi.org/10.1093/jac/dkp144
Lai CC, et al. Comparative in Vitro Activities of Nemonoxacin, Doripenem, Tigecycline and 16 Other Antimicrobials Against Nocardia Brasiliensis, Nocardia Asteroides and Unusual Nocardia Species. J Antimicrob Chemother. 2009;64(1):73-8. PubMed PMID: 19398458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species. AU - Lai,Chih-Cheng, AU - Tan,Che-Kim, AU - Lin,Sheng Hsiang, AU - Liao,Chun-Hsing, AU - Chou,Chien-Hong, AU - Hsu,Hsiao-Leng, AU - Huang,Yu-Tsung, AU - Hsueh,Po-Ren, Y1 - 2009/04/27/ PY - 2009/4/29/entrez PY - 2009/4/29/pubmed PY - 2009/7/28/medline SP - 73 EP - 8 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 64 IS - 1 N2 - OBJECTIVES: The aim of this study was to assess the in vitro activities of nemonoxacin (a novel non-fluorinated quinolone), doripenem, tigecycline and 16 other antimicrobial agents against the Nocardia species. METHODS: MICs of 19 antimicrobial agents for 125 clinical isolates of the Nocardia species were determined by the broth microdilution method. RESULTS: Nocardia brasiliensis (n = 61), Nocardia asteroides (n = 45), Nocardia flavorosea (n = 5), Nocardia otitidiscaviarum (n = 4), Nocardia farcinica (n = 3), Nocardia beijingensis (n = 2), Nocardia puris (n = 2) and one each of Nocardia nova, Nocardia jinanensis and Nocardia takedensis were identified based on a 16S rRNA gene sequencing analysis. For N. brasiliensis isolates, the MIC(90)s of the tested quinolones were in the order nemonoxacin < gemifloxacin = moxifloxacin < levofloxacin = ciprofloxacin, and the MIC(90)s of the tested carbapenems were in the order doripenem = meropenem < ertapenem < imipenem. Tigecycline had a lower MIC(90) (1 mg/L) than linezolid (8 mg/L). For N. asteroides isolates, the MIC(90)s of the tested quinolones were in the order nemonoxacin < gemifloxacin = moxifloxacin < levofloxacin < ciprofloxacin, and the MIC(90)s of the tested carbapenems were in the order doripenem = meropenem = imipenem < ertapenem. For the other 19 Nocardia species isolates, nemonoxacin showed good activity with the lowest MIC(90) of the tested quinolones. Among the four tested carbapenems, doripenem and meropenem had comparatively lower MIC(90)s. CONCLUSIONS: The results of this in vitro study suggest that nemonoxacin, linezolid and tigecycline show promise as treatment options for nocardiosis. Further investigation of their clinical role is warranted. SN - 1460-2091 UR - https://www.unboundmedicine.com/medline/citation/19398458/Comparative_in_vitro_activities_of_nemonoxacin_doripenem_tigecycline_and_16_other_antimicrobials_against_Nocardia_brasiliensis_Nocardia_asteroides_and_unusual_Nocardia_species_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkp144 DB - PRIME DP - Unbound Medicine ER -