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Contribution of nasal biopsy to leprosy diagnosis.
Am J Rhinol Allergy. 2009 Mar-Apr; 23(2):177-80.AJ

Abstract

BACKGROUND

The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients.

METHODS

We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed.

RESULTS

Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis.

CONCLUSION

The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability.

Authors+Show Affiliations

Division of Otorhinolaryngology, National Reference Center for Sanitary Dermatology and Leprosy, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19401045

Citation

Melo Naves, Marcell, et al. "Contribution of Nasal Biopsy to Leprosy Diagnosis." American Journal of Rhinology & Allergy, vol. 23, no. 2, 2009, pp. 177-80.
Melo Naves M, Gomes Patrocinio L, Patrocinio JA, et al. Contribution of nasal biopsy to leprosy diagnosis. Am J Rhinol Allergy. 2009;23(2):177-80.
Melo Naves, M., Gomes Patrocinio, L., Patrocinio, J. A., Naves Mota, F. M., Diniz de Souza, A., Negrão Fleury, R., & Bernardes Goulart, I. M. (2009). Contribution of nasal biopsy to leprosy diagnosis. American Journal of Rhinology & Allergy, 23(2), 177-80. https://doi.org/10.2500/ajra.2009.23.3301
Melo Naves M, et al. Contribution of Nasal Biopsy to Leprosy Diagnosis. Am J Rhinol Allergy. 2009 Mar-Apr;23(2):177-80. PubMed PMID: 19401045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of nasal biopsy to leprosy diagnosis. AU - Melo Naves,Marcell, AU - Gomes Patrocinio,Lucas, AU - Patrocinio,José Antonio, AU - Naves Mota,Flávia Marques, AU - Diniz de Souza,Antônio, AU - Negrão Fleury,Raul, AU - Bernardes Goulart,Isabela Maria, PY - 2009/4/30/entrez PY - 2009/4/30/pubmed PY - 2009/7/16/medline SP - 177 EP - 80 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 23 IS - 2 N2 - BACKGROUND: The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients. METHODS: We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed. RESULTS: Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis. CONCLUSION: The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability. SN - 1945-8924 UR - https://www.unboundmedicine.com/medline/citation/19401045/Contribution_of_nasal_biopsy_to_leprosy_diagnosis_ L2 - https://journals.sagepub.com/doi/10.2500/ajra.2009.23.3301?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -