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New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses.
Emerg Infect Dis. 2009 May; 15(5):719-26.EI

Abstract

Rhinoviruses and enteroviruses are leading causes of respiratory infections. To evaluate genotypic diversity and identify forces shaping picornavirus evolution, we screened persons with respiratory illnesses by using rhinovirus-specific or generic real-time PCR assays. We then sequenced the 5 untranslated region, capsid protein VP1, and protease precursor 3CD regions of virus-positive samples. Subsequent phylogenetic analysis identified the large genotypic diversity of rhinoviruses circulating in humans. We identified and completed the genome sequence of a new enterovirus genotype associated with respiratory symptoms and acute otitis media, confirming the close relationship between rhinoviruses and enteroviruses and the need to detect both viruses in respiratory specimens. Finally, we identified recombinants among circulating rhinoviruses and mapped their recombination sites, thereby demonstrating that rhinoviruses can recombine in their natural host. This study clarifies the diversity and explains the reasons for evolution of these viruses.

Authors+Show Affiliations

University of Geneva Hospitals, Switzerland. caroline.tapparel@hcuge.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19402957

Citation

Tapparel, Caroline, et al. "New Respiratory Enterovirus and Recombinant Rhinoviruses Among Circulating Picornaviruses." Emerging Infectious Diseases, vol. 15, no. 5, 2009, pp. 719-26.
Tapparel C, Junier T, Gerlach D, et al. New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses. Emerg Infect Dis. 2009;15(5):719-26.
Tapparel, C., Junier, T., Gerlach, D., Van-Belle, S., Turin, L., Cordey, S., Mühlemann, K., Regamey, N., Aubert, J. D., Soccal, P. M., Eigenmann, P., Zdobnov, E., & Kaiser, L. (2009). New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses. Emerging Infectious Diseases, 15(5), 719-26. https://doi.org/10.3201/eid1505.081286
Tapparel C, et al. New Respiratory Enterovirus and Recombinant Rhinoviruses Among Circulating Picornaviruses. Emerg Infect Dis. 2009;15(5):719-26. PubMed PMID: 19402957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses. AU - Tapparel,Caroline, AU - Junier,Thomas, AU - Gerlach,Daniel, AU - Van-Belle,Sandra, AU - Turin,Lara, AU - Cordey,Samuel, AU - Mühlemann,Kathrin, AU - Regamey,Nicolas, AU - Aubert,John-David, AU - Soccal,Paola M, AU - Eigenmann,Philippe, AU - Zdobnov,Evgeny, AU - Kaiser,Laurent, PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2009/7/8/medline SP - 719 EP - 26 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 15 IS - 5 N2 - Rhinoviruses and enteroviruses are leading causes of respiratory infections. To evaluate genotypic diversity and identify forces shaping picornavirus evolution, we screened persons with respiratory illnesses by using rhinovirus-specific or generic real-time PCR assays. We then sequenced the 5 untranslated region, capsid protein VP1, and protease precursor 3CD regions of virus-positive samples. Subsequent phylogenetic analysis identified the large genotypic diversity of rhinoviruses circulating in humans. We identified and completed the genome sequence of a new enterovirus genotype associated with respiratory symptoms and acute otitis media, confirming the close relationship between rhinoviruses and enteroviruses and the need to detect both viruses in respiratory specimens. Finally, we identified recombinants among circulating rhinoviruses and mapped their recombination sites, thereby demonstrating that rhinoviruses can recombine in their natural host. This study clarifies the diversity and explains the reasons for evolution of these viruses. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/19402957/New_respiratory_enterovirus_and_recombinant_rhinoviruses_among_circulating_picornaviruses_ L2 - https://dx.doi.org/10.3201/eid1505.081286 DB - PRIME DP - Unbound Medicine ER -