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Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia elliptica.
Phytomedicine. 2009 Dec; 16(12):1144-50.P

Abstract

In this study, six major xanthones, isolated and identified from Halenia elliptica were investigated for their vasodilatory actions in isolated rat coronary artery. The xanthones, including 1-hydroxy-2,3,5-trimethoxy-xanthone (HM-1), 1-hydroxy-2,3,4,7-tetramethoxy-xanthone (HM-2), 1-hydroxy-2,3,4,5-tetramethoxy-xanthone (HM-3), 1,7-dihydroxy-2,3,4,5-tetramethoxy-xanthone (HM-4), 1,5-dihydroxy-2,3-dimethoxy-xanthone (HM-5) and 1,7-dihydroxy-2,3-dimethoxy-xanthone (HM-7) caused vasodilation in the coronary artery pre-contracted with 1 microM 5-hydroxytryptamine (5-HT), with EC(50) values ranging from 1.4+/-0.1 microM (HM-1) to 6.6+/-1.4 microM (HM-2). The EC(50) values of the other xanthones were between those of HM-1 and HM-2. Removal of endothelium of the coronary artery led to decreases in the vasorelaxant effects of HM-1, HM-7 but not HM-2, HM-3, HM-4 and HM-5. Our results showed that xanthones isolated from Halenia elliptica are vasoactive substances which exhibit either endothelium-dependent or endothelium-independent mechanisms in rat coronary artery. The potency and mechanism(s) of the vasorelaxant effects of these xanthones may be relevant to the structure-activity differences in the level and the position of the substituent groups with the primary xanthone structure.

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Authors+Show Affiliations

Wang Y
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Shi JG
No affiliation info available
Wang MZ
No affiliation info available
Che CT
No affiliation info available
Yeung JH
No affiliation info available

MeSH

AnimalsCoronary VesselsDose-Response Relationship, DrugEndothelium, VascularGentianaceaeMalePlant ExtractsRatsRats, Sprague-DawleySerotoninSerotonin AgentsVasodilationVasodilator AgentsXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19403292

Citation

Wang, Yan, et al. "Vasodilatory Actions of Xanthones Isolated From a Tibetan Herb, Halenia Elliptica." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 16, no. 12, 2009, pp. 1144-50.
Wang Y, Shi JG, Wang MZ, et al. Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia elliptica. Phytomedicine. 2009;16(12):1144-50.
Wang, Y., Shi, J. G., Wang, M. Z., Che, C. T., & Yeung, J. H. (2009). Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia elliptica. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 16(12), 1144-50. https://doi.org/10.1016/j.phymed.2009.03.015
Wang Y, et al. Vasodilatory Actions of Xanthones Isolated From a Tibetan Herb, Halenia Elliptica. Phytomedicine. 2009;16(12):1144-50. PubMed PMID: 19403292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia elliptica. AU - Wang,Yan, AU - Shi,Jian-Gong, AU - Wang,Mu-Zou, AU - Che,Chun-Tao, AU - Yeung,John H K, Y1 - 2009/04/29/ PY - 2009/01/15/received PY - 2009/02/10/revised PY - 2009/03/23/accepted PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2010/3/4/medline SP - 1144 EP - 50 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 16 IS - 12 N2 - In this study, six major xanthones, isolated and identified from Halenia elliptica were investigated for their vasodilatory actions in isolated rat coronary artery. The xanthones, including 1-hydroxy-2,3,5-trimethoxy-xanthone (HM-1), 1-hydroxy-2,3,4,7-tetramethoxy-xanthone (HM-2), 1-hydroxy-2,3,4,5-tetramethoxy-xanthone (HM-3), 1,7-dihydroxy-2,3,4,5-tetramethoxy-xanthone (HM-4), 1,5-dihydroxy-2,3-dimethoxy-xanthone (HM-5) and 1,7-dihydroxy-2,3-dimethoxy-xanthone (HM-7) caused vasodilation in the coronary artery pre-contracted with 1 microM 5-hydroxytryptamine (5-HT), with EC(50) values ranging from 1.4+/-0.1 microM (HM-1) to 6.6+/-1.4 microM (HM-2). The EC(50) values of the other xanthones were between those of HM-1 and HM-2. Removal of endothelium of the coronary artery led to decreases in the vasorelaxant effects of HM-1, HM-7 but not HM-2, HM-3, HM-4 and HM-5. Our results showed that xanthones isolated from Halenia elliptica are vasoactive substances which exhibit either endothelium-dependent or endothelium-independent mechanisms in rat coronary artery. The potency and mechanism(s) of the vasorelaxant effects of these xanthones may be relevant to the structure-activity differences in the level and the position of the substituent groups with the primary xanthone structure. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/19403292/Vasodilatory_actions_of_xanthones_isolated_from_a_Tibetan_herb_Halenia_elliptica_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(09)00083-X DB - PRIME DP - Unbound Medicine ER -