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The impact of chronic primary insomnia on the heart rate--EEG variability link.
Clin Neurophysiol. 2009 Jun; 120(6):1054-60.CN

Abstract

OBJECTIVE

To determine if chronic insomnia alters the relationship between heart rate variability and delta sleep determined at the EEG.

METHODS

After one night of accommodation, polysomnography was performed in 14 male patients with chronic primary insomnia matched with 14 healthy men. ECG and EEG recordings allowed the determination of High Frequency (HF) power of RR-interval and delta sleep EEG power across the first three Non Rapid Eye Movement (NREM)-REM cycles. Interaction between normalized HF RR-interval variability and normalized delta sleep EEG power was studied by coherency analysis.

RESULTS

Patients showed increased total number of awakenings, longer sleep latency and wake durations and shorter sleep efficiency and REM duration than controls (p<.01). Heart rate variability across first three NREM-REM cycles and sleep stages (NREM, REM and awake) were similar between both groups. In each group, normalized HF variability of RR-interval decreased from NREM to both REM and awake. Patients showed decreased linear relationship between normalized HF RR-interval variability and delta EEG power, expressed by decreased coherence, in comparison to controls (p<.05). Gain and phase shift between these signals were similar between both groups.

CONCLUSIONS

Interaction between changes in cardiac autonomic activity and delta power is altered in chronic primary insomniac patients, even in the absence of modifications in heart rate variability and cardiovascular diseases.

SIGNIFICANCE

This altered interaction could reflect the first step to cardiovascular disorders.

Authors+Show Affiliations

Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, Free University of Brussels, 1070 Brussels, Belgium. fabrice.jurysta@erasme.ulb.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19403330

Citation

Jurysta, F, et al. "The Impact of Chronic Primary Insomnia On the Heart rate--EEG Variability Link." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 120, no. 6, 2009, pp. 1054-60.
Jurysta F, Lanquart JP, Sputaels V, et al. The impact of chronic primary insomnia on the heart rate--EEG variability link. Clin Neurophysiol. 2009;120(6):1054-60.
Jurysta, F., Lanquart, J. P., Sputaels, V., Dumont, M., Migeotte, P. F., Leistedt, S., Linkowski, P., & van de Borne, P. (2009). The impact of chronic primary insomnia on the heart rate--EEG variability link. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 120(6), 1054-60. https://doi.org/10.1016/j.clinph.2009.03.019
Jurysta F, et al. The Impact of Chronic Primary Insomnia On the Heart rate--EEG Variability Link. Clin Neurophysiol. 2009;120(6):1054-60. PubMed PMID: 19403330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of chronic primary insomnia on the heart rate--EEG variability link. AU - Jurysta,F, AU - Lanquart,J-P, AU - Sputaels,V, AU - Dumont,M, AU - Migeotte,P-F, AU - Leistedt,S, AU - Linkowski,P, AU - van de Borne,P, Y1 - 2009/04/28/ PY - 2008/06/12/received PY - 2009/01/21/revised PY - 2009/03/30/accepted PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2009/6/13/medline SP - 1054 EP - 60 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 120 IS - 6 N2 - OBJECTIVE: To determine if chronic insomnia alters the relationship between heart rate variability and delta sleep determined at the EEG. METHODS: After one night of accommodation, polysomnography was performed in 14 male patients with chronic primary insomnia matched with 14 healthy men. ECG and EEG recordings allowed the determination of High Frequency (HF) power of RR-interval and delta sleep EEG power across the first three Non Rapid Eye Movement (NREM)-REM cycles. Interaction between normalized HF RR-interval variability and normalized delta sleep EEG power was studied by coherency analysis. RESULTS: Patients showed increased total number of awakenings, longer sleep latency and wake durations and shorter sleep efficiency and REM duration than controls (p<.01). Heart rate variability across first three NREM-REM cycles and sleep stages (NREM, REM and awake) were similar between both groups. In each group, normalized HF variability of RR-interval decreased from NREM to both REM and awake. Patients showed decreased linear relationship between normalized HF RR-interval variability and delta EEG power, expressed by decreased coherence, in comparison to controls (p<.05). Gain and phase shift between these signals were similar between both groups. CONCLUSIONS: Interaction between changes in cardiac autonomic activity and delta power is altered in chronic primary insomniac patients, even in the absence of modifications in heart rate variability and cardiovascular diseases. SIGNIFICANCE: This altered interaction could reflect the first step to cardiovascular disorders. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/19403330/The_impact_of_chronic_primary_insomnia_on_the_heart_rate__EEG_variability_link_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(09)00298-3 DB - PRIME DP - Unbound Medicine ER -