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First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants.
Pediatrics. 2009 May; 123(5):1337-43.Ped

Abstract

OBJECTIVE

We sought to evaluate the association between early protein and energy intake and neurodevelopment and growth of extremely low birth weight (<1000 g) infants.

STUDY DESIGN

Daily protein and energy intakes were collected by chart review for the first 4 weeks of life on 148 extremely low birth weight survivors. A total of 124 infants (84%) returned for evaluation at 18 months' corrected age. Bivariate analysis tested correlations between weekly protein or energy intakes and Bayley Mental Development Index, Psychomotor Development Index, or growth at 18 months. Separate regression models evaluated contributions of protein (grams per kilogram per day) and energy intake (kilojoules per kilogram per day) to the Mental Development Index, Psychomotor Development Index, and growth, while controlling for known confounders.

RESULTS

After adjusting for confounding variables, week 1 energy and protein intakes were each independently associated with the Mental Development Index. During week 1, every 42 kJ (10 kcal)/kg per day were associated with a 4.6-point increase in the Mental Development Index and each gram per kilogram per day in protein intake with an 8.2-point increase in the Mental Development Index; higher protein intake was also associated with lower likelihood of length <10th percentile.

CONCLUSIONS

Increased first-week protein and energy intakes are associated with higher Mental Development Index scores and lower likelihood of length growth restrictions at 18 months in extremely low birth weight infants. Emphasis should be placed on providing more optimal protein and energy during this first week.

Authors+Show Affiliations

Department of Pediatrics, Alpert Brown Medical School, Providence, Rhode Island, USA. bstephens@wihri.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19403500

Citation

Stephens, Bonnie E., et al. "First-week Protein and Energy Intakes Are Associated With 18-month Developmental Outcomes in Extremely Low Birth Weight Infants." Pediatrics, vol. 123, no. 5, 2009, pp. 1337-43.
Stephens BE, Walden RV, Gargus RA, et al. First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics. 2009;123(5):1337-43.
Stephens, B. E., Walden, R. V., Gargus, R. A., Tucker, R., McKinley, L., Mance, M., Nye, J., & Vohr, B. R. (2009). First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics, 123(5), 1337-43. https://doi.org/10.1542/peds.2008-0211
Stephens BE, et al. First-week Protein and Energy Intakes Are Associated With 18-month Developmental Outcomes in Extremely Low Birth Weight Infants. Pediatrics. 2009;123(5):1337-43. PubMed PMID: 19403500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. AU - Stephens,Bonnie E, AU - Walden,Rachel V, AU - Gargus,Regina A, AU - Tucker,Richard, AU - McKinley,Leslie, AU - Mance,Martha, AU - Nye,Julie, AU - Vohr,Betty R, PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2009/5/27/medline SP - 1337 EP - 43 JF - Pediatrics JO - Pediatrics VL - 123 IS - 5 N2 - OBJECTIVE: We sought to evaluate the association between early protein and energy intake and neurodevelopment and growth of extremely low birth weight (<1000 g) infants. STUDY DESIGN: Daily protein and energy intakes were collected by chart review for the first 4 weeks of life on 148 extremely low birth weight survivors. A total of 124 infants (84%) returned for evaluation at 18 months' corrected age. Bivariate analysis tested correlations between weekly protein or energy intakes and Bayley Mental Development Index, Psychomotor Development Index, or growth at 18 months. Separate regression models evaluated contributions of protein (grams per kilogram per day) and energy intake (kilojoules per kilogram per day) to the Mental Development Index, Psychomotor Development Index, and growth, while controlling for known confounders. RESULTS: After adjusting for confounding variables, week 1 energy and protein intakes were each independently associated with the Mental Development Index. During week 1, every 42 kJ (10 kcal)/kg per day were associated with a 4.6-point increase in the Mental Development Index and each gram per kilogram per day in protein intake with an 8.2-point increase in the Mental Development Index; higher protein intake was also associated with lower likelihood of length <10th percentile. CONCLUSIONS: Increased first-week protein and energy intakes are associated with higher Mental Development Index scores and lower likelihood of length growth restrictions at 18 months in extremely low birth weight infants. Emphasis should be placed on providing more optimal protein and energy during this first week. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/19403500/First_week_protein_and_energy_intakes_are_associated_with_18_month_developmental_outcomes_in_extremely_low_birth_weight_infants_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=19403500 DB - PRIME DP - Unbound Medicine ER -