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Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk.
Turk Kardiyol Dern Ars. 2009 Mar; 37(2):83-90.TK

Abstract

OBJECTIVES

The impact of alcohol consumption on various outcomes was prospectively evaluated in the participants of the Turkish Adult Risk Factor Study.

STUDY DESIGN

A total of 3,443 men and women (mean age 47.6+/-12 years) were included at baseline and followed-up for a mean of 7.4 years (range 5 to 9 years). Alcohol drinking status was assessed as abstention and brackets of moderate and heavy intake. Only 19.5% of adults (35% of men and 4.2% of women) reported consumption of alcohol. In each multivariate analysis, individuals with the examined endpoint at baseline were excluded, and alcohol drinking status was adjusted for age, sex, smoking status, and physical activity.

RESULTS

Alcohol intake increased overall mortality (by 2-fold) in men drinking heavily, but not in men drinking moderately, nor in women. Heavy drinking in combined sexes predicted the risk for incident coronary heart disease (CHD) (RR 2.3; 95% CI 1.30; 4.05), while moderate drinking tended to be protective (RR 0.72; 95% CI 0.50; 1.035). Heavy intake predicted incident diabetes risk (RR 2.13) and tended to be so for new metabolic syndrome (MetS) in men (RR 1.71), whereas moderate alcohol intake was not significantly associated with subsequent development of diabetes or MetS and the risk for MetS was reduced in women (p=0.10).

CONCLUSION

Risk of alcohol intake depends on the amount used: heavy intake raising the risk for diabetes and CHD in combined sexes, and overall mortality in men, contrasted to moderate intake reducing (borderline) the CHD risk and marginally reducing all-cause mortality. Risk for MetS tends to be reduced in women alone.

Authors+Show Affiliations

Turkish Society of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19404028

Citation

Onat, Altan, et al. "Moderate and Heavy Alcohol Consumption Among Turks: Long-term Impact On Mortality and Cardiometabolic Risk." Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, vol. 37, no. 2, 2009, pp. 83-90.
Onat A, Hergenç G, Küçükdurmaz Z, et al. Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk. Turk Kardiyol Dern Ars. 2009;37(2):83-90.
Onat, A., Hergenç, G., Küçükdurmaz, Z., Uğur, M., Kaya, Z., Can, G., & Yüksel, H. (2009). Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk. Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, 37(2), 83-90.
Onat A, et al. Moderate and Heavy Alcohol Consumption Among Turks: Long-term Impact On Mortality and Cardiometabolic Risk. Turk Kardiyol Dern Ars. 2009;37(2):83-90. PubMed PMID: 19404028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk. AU - Onat,Altan, AU - Hergenç,Gülay, AU - Küçükdurmaz,Zekeriya, AU - Uğur,Murat, AU - Kaya,Zekeriya, AU - Can,Günay, AU - Yüksel,Hüsniye, PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2010/1/12/medline SP - 83 EP - 90 JF - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir JO - Turk Kardiyol Dern Ars VL - 37 IS - 2 N2 - OBJECTIVES: The impact of alcohol consumption on various outcomes was prospectively evaluated in the participants of the Turkish Adult Risk Factor Study. STUDY DESIGN: A total of 3,443 men and women (mean age 47.6+/-12 years) were included at baseline and followed-up for a mean of 7.4 years (range 5 to 9 years). Alcohol drinking status was assessed as abstention and brackets of moderate and heavy intake. Only 19.5% of adults (35% of men and 4.2% of women) reported consumption of alcohol. In each multivariate analysis, individuals with the examined endpoint at baseline were excluded, and alcohol drinking status was adjusted for age, sex, smoking status, and physical activity. RESULTS: Alcohol intake increased overall mortality (by 2-fold) in men drinking heavily, but not in men drinking moderately, nor in women. Heavy drinking in combined sexes predicted the risk for incident coronary heart disease (CHD) (RR 2.3; 95% CI 1.30; 4.05), while moderate drinking tended to be protective (RR 0.72; 95% CI 0.50; 1.035). Heavy intake predicted incident diabetes risk (RR 2.13) and tended to be so for new metabolic syndrome (MetS) in men (RR 1.71), whereas moderate alcohol intake was not significantly associated with subsequent development of diabetes or MetS and the risk for MetS was reduced in women (p=0.10). CONCLUSION: Risk of alcohol intake depends on the amount used: heavy intake raising the risk for diabetes and CHD in combined sexes, and overall mortality in men, contrasted to moderate intake reducing (borderline) the CHD risk and marginally reducing all-cause mortality. Risk for MetS tends to be reduced in women alone. SN - 1016-5169 UR - https://www.unboundmedicine.com/medline/citation/19404028/Moderate_and_heavy_alcohol_consumption_among_Turks:_long_term_impact_on_mortality_and_cardiometabolic_risk_ DB - PRIME DP - Unbound Medicine ER -