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Differential protection by two sunscreens from UV radiation-induced immunosuppression.
J Invest Dermatol. 1991 Oct; 97(4):624-8.JI

Abstract

A controversy has arisen concerning the ability of sunscreens to protect mice from the immunosuppressive effects of UV radiation. We have assessed the photoprotection in hairless mice of two sun protection factor (SPF)15 sunscreens containing different UVB (280-320-nm) absorbers, namely, octyl-N-dimethyl-p-aminobenzoate (o-PABA) or 2-ethylhexyl-p-methoxycinnamate (2-EHMC). Following three minimum erythemal exposures to UV radiation, both systemic suppression of contact hypersensitivity to 2,4-dinitrofluorobenzene and induction of susceptibility to transplanted UV radiation-induced tumor cells was established. Topically applied 2-EHMC sunscreen protected totally from both forms of immunosuppression, but the o-PABA sunscreen failed to protect, although both sunscreens were equally effective in protection from UV radiation-induced erythema and edema.

Authors+Show Affiliations

Reeve VE
Department of Veterinary Pathology, University of Sydney, New South Wales, Australia.
Bosnic M
No affiliation info available
Boehm-Wilcox C
No affiliation info available
Ley RD
No affiliation info available

MeSH

4-Aminobenzoic AcidAnimalsCinnamatesDermatitis, ContactEdemaErythemaImmune ToleranceMaleMiceMice, HairlessNeoplasms, Radiation-InducedSkin NeoplasmsSunscreening AgentsUltraviolet Rays

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1940432

Citation

Reeve, V E., et al. "Differential Protection By Two Sunscreens From UV Radiation-induced Immunosuppression." The Journal of Investigative Dermatology, vol. 97, no. 4, 1991, pp. 624-8.
Reeve VE, Bosnic M, Boehm-Wilcox C, et al. Differential protection by two sunscreens from UV radiation-induced immunosuppression. J Invest Dermatol. 1991;97(4):624-8.
Reeve, V. E., Bosnic, M., Boehm-Wilcox, C., & Ley, R. D. (1991). Differential protection by two sunscreens from UV radiation-induced immunosuppression. The Journal of Investigative Dermatology, 97(4), 624-8.
Reeve VE, et al. Differential Protection By Two Sunscreens From UV Radiation-induced Immunosuppression. J Invest Dermatol. 1991;97(4):624-8. PubMed PMID: 1940432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential protection by two sunscreens from UV radiation-induced immunosuppression. AU - Reeve,V E, AU - Bosnic,M, AU - Boehm-Wilcox,C, AU - Ley,R D, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 624 EP - 8 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 97 IS - 4 N2 - A controversy has arisen concerning the ability of sunscreens to protect mice from the immunosuppressive effects of UV radiation. We have assessed the photoprotection in hairless mice of two sun protection factor (SPF)15 sunscreens containing different UVB (280-320-nm) absorbers, namely, octyl-N-dimethyl-p-aminobenzoate (o-PABA) or 2-ethylhexyl-p-methoxycinnamate (2-EHMC). Following three minimum erythemal exposures to UV radiation, both systemic suppression of contact hypersensitivity to 2,4-dinitrofluorobenzene and induction of susceptibility to transplanted UV radiation-induced tumor cells was established. Topically applied 2-EHMC sunscreen protected totally from both forms of immunosuppression, but the o-PABA sunscreen failed to protect, although both sunscreens were equally effective in protection from UV radiation-induced erythema and edema. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/1940432/Differential_protection_by_two_sunscreens_from_UV_radiation_induced_immunosuppression_ DB - PRIME DP - Unbound Medicine ER -