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Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years.
Biol Trace Elem Res. 2009 Dec; 132(1-3):51-9.BT

Abstract

The objective of the present study was to evaluate the potential effect of maternal cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Between November 2002 and December 2003, 109 normal pregnant women were enrolled in our cohort from Da-Ye Country, Hubei Province in Central China. The placental, whole blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS). The 106 children at 4.5 years of age given birth by the aforementioned women were followed up and the following rate was 97.25%. Detailed questionnaire surveys, anthropometric measurements were performed, and IQ development was evaluated by Wechsler Preschool and Primary Scale of Intelligence Revised Edition (WPPSI-R). Multiple linear regression analysis indicated that cord blood cadmium level was significantly negatively correlated with fetus development. Low birth weight (less than 2,500 g) occurred significantly more frequently in infants with higher cord blood cadmium than in those exposed to lower levels of cord blood cadmium. Significantly negative correlation was found between cord blood cadmium exposure and WPPSI-R IQ full score after controlling for confounding variables. It was concluded that cord blood cadmium concentration was a factor that influenced fetus growth and later IQ development.

Authors+Show Affiliations

Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19404590

Citation

Tian, Li-Li, et al. "Effects of Gestational Cadmium Exposure On Pregnancy Outcome and Development in the Offspring at Age 4.5 Years." Biological Trace Element Research, vol. 132, no. 1-3, 2009, pp. 51-9.
Tian LL, Zhao YC, Wang XC, et al. Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Biol Trace Elem Res. 2009;132(1-3):51-9.
Tian, L. L., Zhao, Y. C., Wang, X. C., Gu, J. L., Sun, Z. J., Zhang, Y. L., & Wang, J. X. (2009). Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Biological Trace Element Research, 132(1-3), 51-9. https://doi.org/10.1007/s12011-009-8391-0
Tian LL, et al. Effects of Gestational Cadmium Exposure On Pregnancy Outcome and Development in the Offspring at Age 4.5 Years. Biol Trace Elem Res. 2009;132(1-3):51-9. PubMed PMID: 19404590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. AU - Tian,Li-Li, AU - Zhao,Yong-Cheng, AU - Wang,Xiao-Chun, AU - Gu,Jin-Long, AU - Sun,Zhi-Juan, AU - Zhang,Ya-Li, AU - Wang,Ji-Xian, PY - 2008/12/18/received PY - 2009/04/16/accepted PY - 2009/5/1/entrez PY - 2009/5/1/pubmed PY - 2011/6/9/medline SP - 51 EP - 9 JF - Biological trace element research JO - Biol Trace Elem Res VL - 132 IS - 1-3 N2 - The objective of the present study was to evaluate the potential effect of maternal cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Between November 2002 and December 2003, 109 normal pregnant women were enrolled in our cohort from Da-Ye Country, Hubei Province in Central China. The placental, whole blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS). The 106 children at 4.5 years of age given birth by the aforementioned women were followed up and the following rate was 97.25%. Detailed questionnaire surveys, anthropometric measurements were performed, and IQ development was evaluated by Wechsler Preschool and Primary Scale of Intelligence Revised Edition (WPPSI-R). Multiple linear regression analysis indicated that cord blood cadmium level was significantly negatively correlated with fetus development. Low birth weight (less than 2,500 g) occurred significantly more frequently in infants with higher cord blood cadmium than in those exposed to lower levels of cord blood cadmium. Significantly negative correlation was found between cord blood cadmium exposure and WPPSI-R IQ full score after controlling for confounding variables. It was concluded that cord blood cadmium concentration was a factor that influenced fetus growth and later IQ development. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/19404590/Effects_of_gestational_cadmium_exposure_on_pregnancy_outcome_and_development_in_the_offspring_at_age_4_5_years_ L2 - https://dx.doi.org/10.1007/s12011-009-8391-0 DB - PRIME DP - Unbound Medicine ER -