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Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status.
Food Chem Toxicol. 2009 Aug; 47(8):1803-9.FC

Abstract

In this study the effect of Helicteres isora L. on erythrocyte membrane bound enzymes and antioxidants activity in plasma and erythrocytes of streptozotocin (STZ) induced diabetic model was investigated. The aqueous bark extract of H. isora was administered orally for 30 days to control and STZ induced diabetic rats. The effect of bark extract on glucose, insulin, haemoglobin, glycosylated haemoglobin, TBARS, hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GPx), glutathione-S-transferase (GST), vitamins C and E, reduced glutathione (GSH) and membrane bound enzymes were studied. The levels of glucose, glycosylated haemoglobin, TBARS, hydroperoxide, and vitamin E were increased significantly whereas the level of insulin, haemoglobin, as well as antioxidants, membrane bound total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were decreased significantly in STZ diabetic rats. Administration of bark extract to diabetic rats showed a decrease in the levels of glucose, glycosylated haemoglobin, lipid peroxidation markers and vitamin E. In addition the levels of insulin, haemoglobin, enzymatic antioxidants, vitamin C, and GSH and the activities of membrane bound enzymes also were increased in H. isora treated diabetic rats. The present study indicates that the H. isora possesses a significant favourable effect on erythrocyte membrane bound enzymes and antioxidants defense system in addition to its antidiabetic effect.

Authors+Show Affiliations

Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627412, Tamil Nadu, India. pgsvedhakumar@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19406193

Citation

Kumar, G, et al. "Influence of Helicteres Isora Administration for Diabetes Mellitus: Its Effect On Erythrocyte Membrane and Antioxidant Status." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 8, 2009, pp. 1803-9.
Kumar G, Banu S, Murugesan AG. Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status. Food Chem Toxicol. 2009;47(8):1803-9.
Kumar, G., Banu, S., & Murugesan, A. G. (2009). Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(8), 1803-9. https://doi.org/10.1016/j.fct.2009.04.027
Kumar G, Banu S, Murugesan AG. Influence of Helicteres Isora Administration for Diabetes Mellitus: Its Effect On Erythrocyte Membrane and Antioxidant Status. Food Chem Toxicol. 2009;47(8):1803-9. PubMed PMID: 19406193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status. AU - Kumar,G, AU - Banu,Sharmila, AU - Murugesan,A G, Y1 - 2009/05/03/ PY - 2009/01/13/received PY - 2009/04/05/revised PY - 2009/04/21/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/10/20/medline SP - 1803 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 8 N2 - In this study the effect of Helicteres isora L. on erythrocyte membrane bound enzymes and antioxidants activity in plasma and erythrocytes of streptozotocin (STZ) induced diabetic model was investigated. The aqueous bark extract of H. isora was administered orally for 30 days to control and STZ induced diabetic rats. The effect of bark extract on glucose, insulin, haemoglobin, glycosylated haemoglobin, TBARS, hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GPx), glutathione-S-transferase (GST), vitamins C and E, reduced glutathione (GSH) and membrane bound enzymes were studied. The levels of glucose, glycosylated haemoglobin, TBARS, hydroperoxide, and vitamin E were increased significantly whereas the level of insulin, haemoglobin, as well as antioxidants, membrane bound total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were decreased significantly in STZ diabetic rats. Administration of bark extract to diabetic rats showed a decrease in the levels of glucose, glycosylated haemoglobin, lipid peroxidation markers and vitamin E. In addition the levels of insulin, haemoglobin, enzymatic antioxidants, vitamin C, and GSH and the activities of membrane bound enzymes also were increased in H. isora treated diabetic rats. The present study indicates that the H. isora possesses a significant favourable effect on erythrocyte membrane bound enzymes and antioxidants defense system in addition to its antidiabetic effect. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19406193/Influence_of_Helicteres_isora_administration_for_diabetes_mellitus:_Its_effect_on_erythrocyte_membrane_and_antioxidant_status_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00201-4 DB - PRIME DP - Unbound Medicine ER -