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Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice.
Food Chem Toxicol. 2009 Aug; 47(8):1771-8.FC

Abstract

The effect of combined therapy with diphenyl diselenide (PhSe)(2) and sodium 2,3-dimercapto-propane-1-sulphonate (DMPS) against alterations induced by mercury (Hg(2+)) was evaluated. Mice were exposed to mercuric chloride (HgCl(2)) (1mg/kg, subcutaneously) for two weeks. After that, mice received (PhSe)(2) (15.6 mg/kg), or DMPS (12.6 mg/kg), or a combination of both for one week. Thiobarbituric acid-reactive substances (TBARS), ascorbic acid and Hg(2+) levels and glutathione S-transferase (GST) and catalase (CAT) activities were carried out in kidney. Hematological parameters, plasmatic bilirubin, uric acid, urea and creatinine levels as well as lactate dehydrogenase (LDH) activity were determined. (PhSe)(2) or DMPS restored the increase in LDH activity and TBARS, bilirubin, uric acid, urea and creatinine levels caused by HgCl(2). The levels of erythrocytes, hemoglobin and hematocrit reduced by HgCl(2) exposure were restored by (PhSe)(2) or DMPS administration in mice. Leukocyte and platelet counts modified by HgCl(2) exposure were restored by (PhSe)(2) or DMPS therapy. DMPS restored the increase in Hg(2+) levels induced by exposure to HgCl(2). Concomitant administration of (PhSe)(2) and DMPS reduced the effectiveness of DMPS in restoring damage induced by HgCl(2). Combined therapy with (PhSe)(2) and DMPS was less effective than isolated therapies in restoring the damage induced by HgCl(2) in mice.

Authors+Show Affiliations

Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19406194

Citation

Brandão, Ricardo, et al. "Concomitant Administration of Sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and Diphenyl Diselenide Reduces Effectiveness of DMPS in Restoring Damage Induced By Mercuric Chloride in Mice." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 8, 2009, pp. 1771-8.
Brandão R, Borges LP, Nogueira CW. Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. Food Chem Toxicol. 2009;47(8):1771-8.
Brandão, R., Borges, L. P., & Nogueira, C. W. (2009). Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(8), 1771-8. https://doi.org/10.1016/j.fct.2009.04.035
Brandão R, Borges LP, Nogueira CW. Concomitant Administration of Sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and Diphenyl Diselenide Reduces Effectiveness of DMPS in Restoring Damage Induced By Mercuric Chloride in Mice. Food Chem Toxicol. 2009;47(8):1771-8. PubMed PMID: 19406194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. AU - Brandão,Ricardo, AU - Borges,Lysandro Pinto, AU - Nogueira,Cristina Wayne, Y1 - 2009/05/03/ PY - 2008/12/10/received PY - 2009/04/04/revised PY - 2009/04/17/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/10/20/medline SP - 1771 EP - 8 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 8 N2 - The effect of combined therapy with diphenyl diselenide (PhSe)(2) and sodium 2,3-dimercapto-propane-1-sulphonate (DMPS) against alterations induced by mercury (Hg(2+)) was evaluated. Mice were exposed to mercuric chloride (HgCl(2)) (1mg/kg, subcutaneously) for two weeks. After that, mice received (PhSe)(2) (15.6 mg/kg), or DMPS (12.6 mg/kg), or a combination of both for one week. Thiobarbituric acid-reactive substances (TBARS), ascorbic acid and Hg(2+) levels and glutathione S-transferase (GST) and catalase (CAT) activities were carried out in kidney. Hematological parameters, plasmatic bilirubin, uric acid, urea and creatinine levels as well as lactate dehydrogenase (LDH) activity were determined. (PhSe)(2) or DMPS restored the increase in LDH activity and TBARS, bilirubin, uric acid, urea and creatinine levels caused by HgCl(2). The levels of erythrocytes, hemoglobin and hematocrit reduced by HgCl(2) exposure were restored by (PhSe)(2) or DMPS administration in mice. Leukocyte and platelet counts modified by HgCl(2) exposure were restored by (PhSe)(2) or DMPS therapy. DMPS restored the increase in Hg(2+) levels induced by exposure to HgCl(2). Concomitant administration of (PhSe)(2) and DMPS reduced the effectiveness of DMPS in restoring damage induced by HgCl(2). Combined therapy with (PhSe)(2) and DMPS was less effective than isolated therapies in restoring the damage induced by HgCl(2) in mice. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19406194/Concomitant_administration_of_sodium_23_dimercapto_1_propanesulphonate__DMPS__and_diphenyl_diselenide_reduces_effectiveness_of_DMPS_in_restoring_damage_induced_by_mercuric_chloride_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00196-3 DB - PRIME DP - Unbound Medicine ER -