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Development and characterization of extended release Kollidon SR mini-matrices prepared by hot-melt extrusion.
Eur J Pharm Biopharm. 2009 Sep; 73(1):140-5.EJ

Abstract

Kollidon SR as a drug carrier and two model drugs with two different melting points, ibuprofen and theophylline, were studied by hot-melt extrusion. Powder mixtures containing Kollidon SR were extruded using a twin-screw extruder at temperatures 70 and 80 degrees C for ibuprofen and 80 and 90 degrees C for theophylline. The glass transition temperature (T(g)) and maximum torque were inversely related to ibuprofen concentrations, indicating its plasticizing effect. The results of differential scanning calorimetry (DSC) and X-ray diffraction analysis showed that ibuprofen remained in an amorphous or dissolved state in the extrudates containing drug up to 35%, whereas theophylline was dispersed in the polymer matrix. The increase in amounts of ibuprofen or theophylline in the hot-melt extrudates resulted in the increase in the drug release rates. Theophylline release rate in hot-melt extruded matrices decreased as the extrusion temperature increased. In contrast, a higher processing temperature caused the higher ibuprofen release. This was a clear indication of the plasticizing effect of ibuprofen on Kollidon SR and a result from water uptake. Theophylline release rate from hot-melt extrudates decreased with increasing triethyl citrate (TEC) level because of the formation of a denser matrix. By adding of Klucel LF as a water-soluble additive to the hot-melt extruded matrices, an increase in ibuprofen and theophylline release rates was obtained.

Authors+Show Affiliations

College of Pharmacy, Freie Universität Berlin, Berlin, Germany. isik.ozguney@ege.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19406237

Citation

Ozgüney, Işik, et al. "Development and Characterization of Extended Release Kollidon SR Mini-matrices Prepared By Hot-melt Extrusion." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 73, no. 1, 2009, pp. 140-5.
Ozgüney I, Shuwisitkul D, Bodmeier R. Development and characterization of extended release Kollidon SR mini-matrices prepared by hot-melt extrusion. Eur J Pharm Biopharm. 2009;73(1):140-5.
Ozgüney, I., Shuwisitkul, D., & Bodmeier, R. (2009). Development and characterization of extended release Kollidon SR mini-matrices prepared by hot-melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 73(1), 140-5. https://doi.org/10.1016/j.ejpb.2009.04.006
Ozgüney I, Shuwisitkul D, Bodmeier R. Development and Characterization of Extended Release Kollidon SR Mini-matrices Prepared By Hot-melt Extrusion. Eur J Pharm Biopharm. 2009;73(1):140-5. PubMed PMID: 19406237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and characterization of extended release Kollidon SR mini-matrices prepared by hot-melt extrusion. AU - Ozgüney,Işik, AU - Shuwisitkul,Duangratana, AU - Bodmeier,Roland, Y1 - 2009/05/04/ PY - 2008/07/18/received PY - 2009/02/04/revised PY - 2009/04/17/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2010/4/20/medline SP - 140 EP - 5 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 73 IS - 1 N2 - Kollidon SR as a drug carrier and two model drugs with two different melting points, ibuprofen and theophylline, were studied by hot-melt extrusion. Powder mixtures containing Kollidon SR were extruded using a twin-screw extruder at temperatures 70 and 80 degrees C for ibuprofen and 80 and 90 degrees C for theophylline. The glass transition temperature (T(g)) and maximum torque were inversely related to ibuprofen concentrations, indicating its plasticizing effect. The results of differential scanning calorimetry (DSC) and X-ray diffraction analysis showed that ibuprofen remained in an amorphous or dissolved state in the extrudates containing drug up to 35%, whereas theophylline was dispersed in the polymer matrix. The increase in amounts of ibuprofen or theophylline in the hot-melt extrudates resulted in the increase in the drug release rates. Theophylline release rate in hot-melt extruded matrices decreased as the extrusion temperature increased. In contrast, a higher processing temperature caused the higher ibuprofen release. This was a clear indication of the plasticizing effect of ibuprofen on Kollidon SR and a result from water uptake. Theophylline release rate from hot-melt extrudates decreased with increasing triethyl citrate (TEC) level because of the formation of a denser matrix. By adding of Klucel LF as a water-soluble additive to the hot-melt extruded matrices, an increase in ibuprofen and theophylline release rates was obtained. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/19406237/Development_and_characterization_of_extended_release_Kollidon_SR_mini_matrices_prepared_by_hot_melt_extrusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(09)00138-6 DB - PRIME DP - Unbound Medicine ER -